Inflammation Markers in Essential Hypertension

Tsounis, Dimitrios; Bouras, Georgios; Γιαννόπουλος, Γεώργιος; Papadimitriou, Charalampos; Alexopoulos, Dimitrios; Deftereos, Spyridon

doi:10.2174/1573406410666140318111328

Cited by 43 publications

(28 citation statements)

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“…It may result in various ailments, such as bronchitis, arthritis deformans, colitis, gravis, artherosclerosis, and/or parasitic diseases [1][2][3]. Inflammatory responses caused by infectious and non-infectious external factors induce reactive oxygen and nitrogen species, which include hydrogen peroxide (H 2 O 2 ), nitric oxide (NO), and reactive intermediates such as hydroxyl radicals (OH•), superoxide (O 2 •−), and peroxynitrite (ONOO−) [4,5].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, anti-inflammatory, and antioxidant effects of Yinzhihuang injection

Liu

Qiu

Zhao-rong

et al. 2015

BME

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Abstract. The Yinzhihuang injection, a traditional Chinese medicine, has been the recent target of increasing interest due to its anti-inflammatory properties. The molecular basis by which Yinzhihuang injection could cure Riemerella anatipestifer (RA) serositis in ducks is unclear. This study evaluated the antibacterial, anti-inflammatory and antioxidant effects of Yinzhihuang injection, using disease models of RA-induced infectious serositis in ducks and heptane-induced inflammation in mice and rats. The duck mortality rate was reduced from 60% to 20% and both the inflammatory response and histological damage were ameliorated by treatment with Yinzhihuang injection (0.02 g/kg). Further studies indicated that superoxide dismutase (SOD), nitric oxide synthase (NOS), and inducible nitric oxide synthase (iNOS) were elevated while malondialdehyde (MDA), nitric oxide (NO) and RA growth were inhibited when the ducks were treated by Yinzhihuang injection. In addition, Yinzhihuang injection (0.04 g/ml) effectively inhibited xylene-induced auricle swelling in mice, (demonstrating an inhibition rate of 35.21%), egg albumen-induced paw metatarsus swelling in rats, (demonstrating an inhibition rate of 22.30%), and agar-induced formation of granulation tissue. These results suggest that Yinzhihuang injection ameliorates RA-induced infectious serositis in ducks by modulation of inflammatory mediators and antioxidation.

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Section: Introductionmentioning

confidence: 99%

Antibacterial, anti-inflammatory, and antioxidant effects of Yinzhihuang injection

Liu

Qiu

Zhao-rong

et al. 2015

BME

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“…Therefore, endothelial dysfunction reduces vasodilation, increases vascular resistance, thus, limit insulin and glucose delivery in the sensitive tissues (ie, skeletal muscle, liver, and adipose tissue) and blunts insulin-stimulated glucose uptake [9,48]. There was a low-grade inflammatory reaction in patients with diabetes and hypertension [49,50]. High blood pressure increases the level of inflammatory markers, such as C-reactive protein,interleukin 6 and adhesion molecules which related to the insulin signaling pathway and β-cell function and further lead to the incident diabetes [51,52].In addition, oxidative stress-related cytokines (interleukin-1, interleukin-6 and tumor necrosis factor-a) could modify glucose metabolism which may contribute to the pathophysiology of diabetes mellitus [53].…”

Section: Discussionmentioning

confidence: 99%

Association of hypertension and incident diabetes in Chinese adults: a retrospective cohort study using propensity-score matching

Chen

et al. 2020

Preprint

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Background Previous studies have revealed that hypertension is one of major risk factors of incident diabetes. However, reliable quantification of the relationship between hypertension and diabetes risk is limited, especially in Chinese people. We aimed to investigate the association between hypertension and risk of incident diabetes in a large cohort of Chinese population. Methods This was a retrospective propensity score-matched cohort study. We enrolled 211809 Chinese adults without diabetes at baseline between 2010 and 2016. The target independent and dependent variable were hypertension at baseline and incident diabetes during follow-up respectively. The one to one propensity score matching using a non-parsimonious multivariable logistic regression was conducted to balance the confounders between 28,946 hypertensive patients and 28,946 non-hypertensive participants. The doubly robust estimation method was used to investigate the association between hypertension and incident diabetes. Result After propensity-score matching, the cumulative incidence of diabetes among hypertensive and non-hypertensive participants were 1627.690 per 100,000 person-years and 1414.422 per 100,000 person-years, respectively. In the propensity-score matching cohort, compared to the non-hypertensive participants, the risk of incident diabetes increased by 14.0% among hypertensive subjects (HR = 1.140, 95% confidence interval (CI): 1.058–1.229, P = 0.00063). After adjusting for the demographic and clinical covariates, diabetes risk increased by 13.1% in the hypertensive group (HR = 1.131, 95%CI: 1.049–1.220, P = 0.00143). And diabetes risk increased by 15.4% among hypertensive subjects after adjusting for the propensity score (HR = 1.154, 95%CI:1.070–1.244, P = 0.00019).In the subgroup analysis, compared to non-hypertensive participants with low propensity score, the risk of incident diabetes increased by 2.6 times among hypertensive patients with high propensity score (HR = 3.610,95%CI: 2.604–5.005,P < 0.00001). In the sensitivity analysis, the risk of diabetes in the hypertensive group increased by 11.7% in the original cohort (HR = 1.117༌95%CI: 1.044–1.196,P = 0.00134) and 19.9% in the weighted cohort(HR = 1.199༌95%CI: 1.149–1.250,P < 0.00001), respectively. Conclusion Hypertension was associated with a 13.1% increase in the risk of developing diabetes in Chinese adults. Additionally, compared to non-hypertensive participants with low propensity score, the risk of incident diabetes increased by 2.6 times among hypertensive patients with high propensity score.

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“…In addition, several inflammatory mediators are speculated to be associated with an increased risk for HT. An understanding of inflammatory modulation by C-reactive protein, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and chemokines is important because these modulators may influence therapeutic responses, as well as clinical outcomes in patients with HT 7) . Therefore, several therapeutic approaches targeting BP may have beneficial effects on inflammation that may lead to further clinical benefits.…”

Section: -1 Htmentioning

confidence: 99%

Do antilipidemic agents reduce blood pressure?

2018

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Abstract:Currently, the prevalence of hypertension (HT), diabetes mellitus (DM), and hyperlipidemia (HL) is high, and these diseases are important risk factors for cardiovascular disease (CVD). Furthermore, patients with CVD often have more than one of these diseases. Generally, patients take multiple drugs for each disease. Therefore, clinicians must pay attention to drug interactions. Although HT, DM, and HL are different diseases, they share some of the same pathophysiological mechanisms and ultimately lead to the same cardiovascular events.Currently, most patients with CVD are treated with 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins), and various beneficial pleiotropic effects of statins have been reported since the 1990s.In this review, we evaluate the additional effects of antihyperlipidemic agents on blood pressure (BP).

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Inflammation Markers in Essential Hypertension

Cited by 43 publications

References 0 publications

Antibacterial, anti-inflammatory, and antioxidant effects of Yinzhihuang injection

Antibacterial, anti-inflammatory, and antioxidant effects of Yinzhihuang injection

Association of hypertension and incident diabetes in Chinese adults: a retrospective cohort study using propensity-score matching

Do antilipidemic agents reduce blood pressure?

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