Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease

Luo, Yunfei; Lin, Hui

doi:10.1002/iid3.391

Cited by 68 publications

(52 citation statements)

References 140 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NAFLD is a low-grade inflammatory chronic disease that the process of its occurrence and progression is accelerated by the high level of pro-inflammatory cytokines, including Interleukin‐1, TNF‐α, and Interleukin‐6 and the high level secretion of adipokines. These inflammatory factors trigger various processes, including lipotoxicity, hepatocyte cell death, liver inflammation, fibrosis, and pathological angiogenesis [ 39 ]. Therefore, any environmental factor affecting the creation or exacerbation of inflammatory conditions, such as greater adherence to a pro-inflammatory dietary pattern, which is associated with increased cellular or serum levels of these inflammatory markers, can increase the risk of fatty liver disease or its progression.…”

Section: Discussionmentioning

confidence: 99%

The association between dietary inflammation scores and non-alcoholic fatty liver diseases in Iranian adults

et al. 2022

View full text Add to dashboard Cite

Background Potential dietary inflammation can precursor chronic diseases such as hepatic disorders. We aimed to examine the association of empirical dietary inflammatory patterns (EDIP) and dietary inflammation scores (DIS) with the risk of nonalcoholic fatty liver diseases (NAFLD) in Iranian adults. Methods This case–control study was conducted on 225 newly diagnosed NAFLD cases and 450 controls aged 20–60 years. The individuals’ dietary data were collected using a validated food frequency questionnaire. The detection of NAFLD in subjects was done using the ultrasonography scan of the liver and confirmation of gastroenterologists. To calculate of EDIP score, the average daily intakes of each item (15 food items) were multiplied by the proposed weights, and then all the weighted values were summed. Also, to calculate the DIS score, each food item (18 food items) is multiplied by its specific weight to obtain the weighted values of each item. The weighted values were then standardized using the Z-score. Finally, the standardized weighted values of all the items were summed to get the overall DIS score for the individuals. Logistic regression models, adjusted for potential confounders, were used to estimate the odds ratios and 95% confidence interval (CI) of NAFLD across tertiles of EDIP and DIS. Results The mean (SD) age and BMI of the study population (53% male) were 38.1 (8.8) years and 26.8 (4.3) kg/m2, respectively. The median (IQR) of EDIP and DIS scores in individuals were 0.52 (0.34, 0.73), and 0.04 (− 0.55, 0.59), respectively. Based on the multivariable-adjusted model, after controlling for age, sex, physical activity, smoking, marital status, waist-to-hip ratio, and dietary energy intake, individuals in the second (OR 2.01, 95% CI 1.07–3.76) and third tertiles of DIS (OR 2.54, 95% CI 1.39–4.63) had a higher odds of NAFLD compared to the lowest tertile of DIS (Ptrend = 0.003). Also, in the final model, there is a significant direct association between EDIP score and odds of NAFLD [(OR T2 vs. T1 = 0.88, 95% CI 0.50–1.57) and (OR T3 vs. T1 = 1.82, 95% CI 1.02–3.23)], (Ptrend = 0.031). Conclusion Our results suggested that higher scores of EDIP and DIS, indicating the high inflammatory potential of dietary pattern, are associated with increased odds of NAFLD in Iranian adults.

show abstract

Section: Discussionmentioning

confidence: 99%

The association between dietary inflammation scores and non-alcoholic fatty liver diseases in Iranian adults

et al. 2022

View full text Add to dashboard Cite

show abstract

“…NAFLD is involved in chronic and low-grade inflammation ( Luo and Lin, 2020 ). This study showed that IsA treatment improved liver injury and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Ilexsaponin A1 Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease by Regulating Bile Acid Metabolism in Mice

Zhao

Meng

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Bile acid (BA) metabolism is an attractive therapeutic target in nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the effect of ilexsaponin A1 (IsA), a major bioactive ingredient of Ilex, on high-fat diet (HFD)-induced NAFLD in mice with a focus on BA homeostasis. Male C57BL/6J mice were fed an HFD to induce NAFLD and were treated with IsA (120 mg/kg) for 8 weeks. The results showed that administration of IsA significantly decreased serum total cholesterol (TC), attenuated liver steatosis, and decreased total hepatic BA levels in HFD-induced NAFLD mice. IsA-treated mice showed increased BA synthesis in the alternative pathway by upregulating the gene expression levels of sterol 27-hydroxylase (CYP27A1) and cholesterol 7b-hydroxylase (CYP7B1). IsA treatment accelerated efflux and decreased uptake of BA in liver by increasing hepatic farnesoid X receptor (FXR) and bile salt export pump (BSEP) expression, and reducing Na+-taurocholic acid cotransporting polypeptide (NTCP) expression. Alterations in the gut microbiota and increased bile salt hydrolase (BSH) activity might be related to enhanced fecal BA excretion in IsA-treated mice. This study demonstrates that consumption of IsA may prevent HFD-induced NAFLD and exert cholesterol-lowering effects, possibly by regulating the gut microbiota and BA metabolism.

show abstract

“…Obesity is a health problem, and nonalcoholic fatty liver (NAFLD) is a common ailment belonged to obesity. It is characterized by the accumulation of fat in the liver cells, and the hepatocytes [36]. The latest evidence has shown that phenolic compounds can enhance the absorption of nutrients, lipid metabolism, and weight loss [37].…”

Section: Bee Pollen Prevents Obesity and Combats Liver Disordersmentioning

confidence: 99%

Bee Pollen: Current Status and Therapeutic Potential

et al. 2021

View full text Add to dashboard Cite

Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry.

show abstract

Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease

Cited by 68 publications

References 140 publications

The association between dietary inflammation scores and non-alcoholic fatty liver diseases in Iranian adults

The association between dietary inflammation scores and non-alcoholic fatty liver diseases in Iranian adults

Ilexsaponin A1 Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease by Regulating Bile Acid Metabolism in Mice

Bee Pollen: Current Status and Therapeutic Potential

Contact Info

Product

Resources

About