2011
DOI: 10.1007/s12031-011-9613-4
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Inflammation-Induced Changes in the Chemical Coding Pattern of Colon-Projecting Neurons in the Inferior Mesenteric Ganglia of the Pig

Abstract: The present study examines the chemical coding of the inferior mesenteric ganglia after chemically induced colitis in the pig animal model. In all animals (n = 6), a median laparotomy was performed under anesthesia, and the Fast Blue retrograde tracer was injected into the descending colon wall. In experimental animals (n = 3), the thick descending colon were injected with formalin solution to induce inflammation. The animals were euthanized and the inferior mesenteric ganglion was harvested and processed for … Show more

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Cited by 10 publications
(11 citation statements)
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“…The increase of the number of nerves showing the presence of NRG-1, which has a neuroprotective activity [ 59 ], may be the answer for these processes. Such a thesis is also supported by the fact that the expression of other neuronal substances (including VIP, GAL, SP, and CART), which co-localize with NRG-1 in the same nerves and which are considered to be important neuroprotective factors [ 60 , 61 , 62 ] is also higher after BPA administration.…”
Section: Discussionmentioning
confidence: 93%
“…The increase of the number of nerves showing the presence of NRG-1, which has a neuroprotective activity [ 59 ], may be the answer for these processes. Such a thesis is also supported by the fact that the expression of other neuronal substances (including VIP, GAL, SP, and CART), which co-localize with NRG-1 in the same nerves and which are considered to be important neuroprotective factors [ 60 , 61 , 62 ] is also higher after BPA administration.…”
Section: Discussionmentioning
confidence: 93%
“…Cell bodies of parasympathetic neurons supplying the GI tract are located in dorsal motor nucleus and nucleus ambiguous of the vagal nerve (these neurons supply the GI tract from the oesophagus to the proximal colon), as well as in parasympathetic nuclei of the sacral spinal cord (they innervate the distal colon and rectum) [99,102,103,104]. In turn, the cell bodies of sympathetic neurons supplying the cranial part of the GI tract (from oesophagus to proximal colon) are localized in celiac ganglia, and those innervating distal colon and rectum are placed in the superior and inferior mesenteric ganglia [105,106,107]. Moreover, it is known that sympathetic neurons supplying the GI tract are also present in the sympathetic chain [98].…”
Section: Som In the Extrinsic Innervation Of The Gastrointestinal mentioning
confidence: 99%
“…Nevertheless, the most thorough investigations concerning the distribution of SOM in the extrinsic gastrointestinal innervation have been conducted on the domestic pig, which may be the best animal model of human gastrointestinal innervation [42]. In the domestic pig, SOM has been observed in neurons supplying the descending colon and located in the inferior mesenteric ganglia (IMG) [105,106]. Such neurons under physiological conditions amounted to about 12% of the total IMG neuronal cells supplying the colon and often showed the co-localization of SOM and GAL.…”
Section: Som In the Extrinsic Innervation Of The Gastrointestinal mentioning
confidence: 99%
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“…20 The number of inferior mesenteric ganglion neurons expressing neuroprotective neuropeptides was reduced, reflecting the changes in the chemical coding of inferior mesenteric ganglion neurons during intestinal inflammation. 21 Through vagal efferent nerves and neuromediators, the central nerve system could effectively influence immune cells and modulate intestinal inflammation. 22,23 The important role of VN in intestinal inflammation has been demonstrated by studies with vagotomized mice, which is susceptible to develop colitis when exposure to dextran sulphate sodium.…”
Section: Mesenteric Nervesmentioning
confidence: 99%