Inflammation in Peripheral Artery Disease

Brevetti, Gregorio; Giugliano, Giuseppe; Brevetti, Linda; Hiatt, William R.

doi:10.1161/circulationaha.109.918417

Cited by 258 publications

(218 citation statements)

References 227 publications

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“…Vulnerable atherosclerotic plaques are more susceptible to destabilization and rupture, compared to stable fibrotic plaques, leading to clinical events characterized by increased infiltration of leukocytes and other inflammatory mediators [15,16]. Bacteremia may contribute to vascular thrombosis in Peripheral artery disease, which can predict cardiac and cerebral ischemic events [17]. Atherosclerotic plaque rupture is the initiating event resulting in most acute coronary syndromes including unstable angina and MI [18].…”

Section: Atherosclerosismentioning

confidence: 99%

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

2017

JCCR

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The circulating microbiome or the blood microbiome has been analysed recently in chronic inflammatory diseases like obesity, diabetes, cirrhosis and cardiovascular diseases (CVDs) in humans. Evidences that microbial components in blood could play a crucial role in the pathophysiological events leading to or during the course of disease continue to mount. The blood microbiome has been investigated primarily by profiling the circulating bacterial and viral elements using high-throughput sequencing technologies. However, the clinical implications of circulating microbiome in humans remain largely unexplored. The evidence for the presence of a stable blood microbiome in CVDs is still questionable. Nevertheless, there is evidence for a link between the circulating microbiome in obesity, diabetes and CVDs, indicating the influence of physiological, biochemical and environmental factors on the circulating microbiome in metabolic diseases. With this background, we explore the reports on the clinical consequences of bacteremia in CVD patients which formed the basis for the analyses on the topic "circulating microbiome".

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Section: Atherosclerosismentioning

confidence: 99%

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

2017

JCCR

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“…51 The association with these factors can be explained because of the high proatherosclerotic risk profile in PAD, characterized by endothelial dysfunction and systemic low-grade inflammatory activity. 52 Several markers of inflammation, such as serum C-reactive protein and interleukin-6, have been found to be associated with symptomatic PAD independently of traditional cardiovascular risk factors. 53 Moreover, a graded direct dose-response relationship between inflammatory…”

Section: Control Of Risk Factors For Pad and The Need For Primary Prementioning

confidence: 99%

Lifestyle and Dietary Risk Factors for Peripheral Artery Disease

Ruiz‐Canela

Martínez‐González

2014

Circ J

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“…PAD affects more than 12 million people in the United States and it increases with age [2][3][4]. Globally, 27 million people are affected by PAD and other atherosclerotic diseases [5,6]. Among the existing PAD patients, 20% of the patients suffer with intermittent claudication annually [2].…”

Section: Introductionmentioning

confidence: 99%

“…These triggers promote stress and enhance inflammatory paths either directly or indirectly. PAD is also observed commonly in 33% of monozygotic twin pair's and 31% of dizygotic twin pairs due to heritability [6]. Lower Extremity PAD patients can be tested using noninvasive vascular laboratory tests and they are represented in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Flow Dynamics and Wall Shear Stresses in a Bifurcated Femoral Artery

Gogineni¹,

Ts²

2017

J Biomed Eng Med Devic

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The present paper presents peak wall shear stresses and velocities in a bifurcated femoral artery. This artery is modeled along with blockage downstream of bifurcation, blockage at bifurcation, blockage downstream of stented femoral artery. The femoral artery is subjected to peripheral artery disease. A two-dimensional computational fluid dynamic analysis is conducted in all the models, assuming steady blood flow and seventy percent plaque. However, the blood viscosity and blood pressure vary in the femoral artery models as they are subjected to other medical conditions. Femoral artery bifurcates into profunda femoris and the bifurcation angles are assumed to vary at 30, 45 and 60 degrees. The blocked bifurcated artery is replaced with a wall stent and in many cases, a blockage develops downstream of the bifurcated stented artery as a consequence of stent implantation. The wall shear stresses and velocities results from the bifurcated and blocked femoral arterial models are compared to a normal artery characteristic. Further, a comparative study has been conducted along the blocked bifurcated artery with and without the stent.

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Inflammation in Peripheral Artery Disease

Cited by 258 publications

References 227 publications

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

Lifestyle and Dietary Risk Factors for Peripheral Artery Disease

Flow Dynamics and Wall Shear Stresses in a Bifurcated Femoral Artery

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