Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

Abstract

The circulating microbiome or the blood microbiome has been analysed recently in chronic inflammatory diseases like obesity, diabetes, cirrhosis and cardiovascular diseases (CVDs) in humans. Evidences that microbial components in blood could play a crucial role in the pathophysiological events leading to or during the course of disease continue to mount. The blood microbiome has been investigated primarily by profiling the circulating bacterial and viral elements using high-throughput sequencing technologies. However, the clinical implications of circulating microbiome in humans remain largely unexplored. The evidence for the presence of a stable blood microbiome in CVDs is still questionable. Nevertheless, there is evidence for a link between the circulating microbiome in obesity, diabetes and CVDs, indicating the influence of physiological, biochemical and environmental factors on the circulating microbiome in metabolic diseases. With this background, we explore the reports on the clinical consequences of bacteremia in CVD patients which formed the basis for the analyses on the topic "circulating microbiome".

Comparison of Microbial Populations in the Blood of Patients With Myocardial Infarction and Healthy Individuals

“…Simultaneously, the role of oral microbiota in the etiology of these diseases has been extensively investigated. Studies on blood microbiota provide the first line of evidence for the involvement of tissue microbiota in CVD, as well as provide some insight into the mechanism of action of the circulating bacteria (Dinakaran, 2017 ).…”