Inflammation, Immunity, and Oxidative Stress in Hypertension—Partners in Crime?

Barrows, Ian R.; Ramezani, Ali; Raj, Dominic S.

doi:10.1053/j.ackd.2019.03.001

Cited by 82 publications

(58 citation statements)

References 108 publications

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“…Some studies have indicated that lipid peroxidation in ferroptosis can promote the inflammation and regulate the level of different inflammatory cytokines [39,51,52], which is consistent with our results. Moreover, the excessive accumulation of ROS also causes oxidative damage and an inflammatory response in lung tissues [53][54][55]. Ferroptosis is mainly induced by the failure of membrane lipid repair, and further leads to the increase of ROS on the membrane lipids.…”

Section: Discussionmentioning

confidence: 99%

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

et al. 2020

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Background: Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed the relationship between ferroptosis and LPS-induced ALI. Methods: In this study, a human bronchial epithelial cell line, BEAS-2B, was treated with LPS and ferrostatin-1 (Fer-1, ferroptosis inhibitor). The cell viability was measured using CCK-8. Additionally, the levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and iron, as well as the protein level of SLC7A11 and GPX4, were measured in different groups. To further confirm the in vitro results, an ALI model was induced by LPS in mice, and the therapeutic action of Fer-1 and ferroptosis level in lung tissues were evaluated. Results: The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4, while the levels of MDA, 4-HNE and total iron were increased by LPS treatment in a dose-dependent manner, which could be rescued by Fer-1. The results of the in vivo experiment also indicated that Fer-1 exerted therapeutic action against LPS-induced ALI, and down-regulated the ferroptosis level in lung tissues. Conclusions: Our study indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroptosis may become a novel target in the treatment of ALI patients.

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Section: Discussionmentioning

confidence: 99%

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

et al. 2020

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“…141 There is now extensive experimental and clinical evidence indicating that hypertension is associated with inflammation, fibrosis, and activation of immune cells, processes that are driven in large part by oxidative stress. 142 Tissue expression of adhesion molecules (VCAM-1, ICAM-1), production of inflammatory mediators (monocyte chemotactic peptide 1, tumour necrosis factor, interleukin [IL] 1, IL-6, 1L-17), activation of proinflammatory signalling pathways (MAPK, STAT) and transcription factors (NF-kB, AP-1, HIF-1), and circulating levels of inflammatory biomarkers (C-reactive protein, PAI-1, ILs) are increased in hypertension. [143][144][145][146] Although it still remains unclear whether inflammation is a cause or an effect of hypertension, it is clear that the immune system and ROS are important players.…”

Section: Oxidative Stress and Inflammation In Hypertensionmentioning

confidence: 99%

Oxidative Stress: A Unifying Paradigm in Hypertension

Touyz

Ríos

Alves-Lopes

et al. 2020

Canadian Journal of Cardiology

173

129

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The etiology of hypertension involves complex interactions among genetic, environmental, and pathophysiologic factors that influence many regulatory systems. Hypertension is characteristically associated with vascular dysfunction, cardiovascular remodelling, renal dysfunction, and stimulation of the sympathetic nervous system. Emerging evidence indicates that the immune system is also important and that activated immune cells migrate and accumulate in tissues promoting inflammation, fibrosis, and target-organ damage. Common to these processes is oxidative stress, defined as an imbalance between

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“…Whether inflammation is a cause or effect of hypertension remains unclear. Since this relationship is further confounded by the fact that several factors associated with hypertension, such as obesity or insulin resistance, are also associated with inflammation [10,12]. A role of a cell surface multi-ligand pattern recognition receptor for advanced glycation end products (RAGE) in pathogenesis of hypertension cannot be excluded.…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Association of Elevated Blood Pressure with Variables Characterizing Cardiometabolic Risk in Young Subjects with or Without Metabolic Abnormalities

Šebeková

Gurecká

Csongová

et al. 2020

IJERPH

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Males present higher blood pressure (BP) values, higher prevalence of elevated BP, and a different prevalence of cardiometabolic risk factors when compared with females. We assumed that the trends of risk markers across BP categories (normotension, high normal BP, and hypertension) differ in young males and females, and between subjects without metabolic abnormalities (without obesity, insulin resistance, atherogenic dyslipidemia, hyperuricemia, or microinflammation) and those presenting them. Data from 2543 subjects (48% males) aged from 16 to 23 years were analyzed. The findings showed that 15% of males and 4% of females presented high normal BP while 9% and 1%, respectively, had hypertension. In males, variables characterizing obesity status, insulin sensitivity, atherogenic dyslipidemia, uric acid, adiponectin, a soluble receptor for advanced glycation end-products, and leukocyte counts showed worsening trends across BP categories. Females presented significant trends only for obesity measures, LDL-cholesterol, and non-HDL-cholesterol. Across BP categories, trends of variables characterizing cardiometabolic risk differed among abnormalities-free and presenting males. The multivariate model selected measures of central obesity, atherogenic dyslipidemia, insulin resistance, and uric acid as significant predictors of BP in both genders, and C-reactive protein in females. Sex differences in measures of cardiovascular health in juveniles may remain undiscovered unless two sexes are analyzed separately. These differences may have implications for sex-specific disease risk in adulthood.

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Inflammation, Immunity, and Oxidative Stress in Hypertension—Partners in Crime?

Cited by 82 publications

References 108 publications

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

Oxidative Stress: A Unifying Paradigm in Hypertension

Sex Differences in Association of Elevated Blood Pressure with Variables Characterizing Cardiometabolic Risk in Young Subjects with or Without Metabolic Abnormalities

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