Inflammation as a possible link between coronary and carotid plaque instability

Lombardo, Antonio; Biasucci, Luigi M.; Lanza, Gaetano Antonio

doi:10.1016/j.accreview.2004.08.048

Cited by 71 publications

(88 citation statements)

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“…There is also evidence from small studies of an association between high-risk carotid plaques and complex coronary lesions and coronary adverse events. 20,21 The present investigation has demonstrated that progressive carotid stenosis indicates an increased risk for clinical adverse events of atherosclerosis in the coronary and peripheral as well as in the cerebrovascular circulation. In other vascular territories, particularly the coronary arteries, rupture is the predominant cause of atherothrombotic events.…”

Section: Discussionmentioning

confidence: 97%

Progression of Carotid Stenosis Detected by Duplex Ultrasonography Predicts Adverse Outcomes in Cardiovascular High-Risk Patients

Sabeti

Schlager

Exner

et al. 2007

Stroke

103

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Background and Purpose-The progression of carotid stenosis reflects the activity of atherosclerotic disease and may indicate a risk for systemic atherothrombotic complications. We investigated whether progressive carotid stenosis determined by duplex ultrasonography predicts adverse outcomes in cardiovascular high-risk patients. Methods-We prospectively studied 1065 of 1268 consecutive patients initially asymptomatic with respect to carotid disease. Carotid ultrasound investigations at baseline and after a median of 7.5 months (range, 6 to 9 months) were performed to identify patients with progressive stenosis as defined by Doppler velocity criteria.

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Section: Discussionmentioning

confidence: 97%

Progression of Carotid Stenosis Detected by Duplex Ultrasonography Predicts Adverse Outcomes in Cardiovascular High-Risk Patients

Sabeti

Schlager

Exner

et al. 2007

Stroke

103

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“…CIMT was measured offline by using computer software (M'ATH, Paris, France), which can automatically define CIMT to within 0.001 mm. Carotid plaques were defined as a focal widening of the vessel wall relative to the adjacent wall, protruding into the lumen as proposed by Lombardo et al 16 . These procedures were performed within the first week of initial presentation to the hospital.…”

Section: Methodsmentioning

confidence: 99%

Early onset of subclinical atherosclerosis in women with gestational diabetes mellitus

Tarım

Yiğit

Kılıçdağ

et al. 2006

Ultrasound Obstet Gynecol

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“…Many large population-based studies have demonstrated that C-reactive protein (CRP), as a representative inflammatory marker, can predict future cardiovascular events 2, 37) . Lombardo et al 38) performed carotid ultra- 39) investigated the association between increased serum concentrations of neopterin and the extent of carotid atherosclerosis in a community-based study, there are no findings on the association between neopterin and characteristics of carotid plaques, which may be closely associated with the risk of stroke. We hypothesized that the increased plasma neopterin levels in patients with SAP may be related to carotid plaque instability, which is characteristic of complex plaques as well as coronary lesions.…”

Section: Neopterin and Plaque Instability In Carotid Arteriesmentioning

confidence: 99%

Neopterin and Atherosclerotic Plaque Instability in Coronary and Carotid Arteries

Sugioka

Naruko

Matsumura

et al. 2010

JAT

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Inflammation plays a key role in atherosclerosis and plaque vulnerability, and monocyte/macrophage activation contributes to these processes. Neopterin, a by-product of the guanosine triphosphate pathway, is produced by activated macrophages on stimulation with interferon-released from T lymphocytes, and is an activation marker for monocytes/macrophages. Coronary angiographic studies have shown a relationship between increased circulating levels of neopterin and the presence of complex coronary lesions in patients with unstable angina pectoris (UAP). Furthermore, in an immunohistochemical study performed using coronary atherectomy specimens, a significantly higher prevalence of neopterin-positive macrophages was found in culprit lesions in patients with UAP than in those with stable angina pectoris (SAP). We recently clarified that the presence of complex carotid plaques detected by carotid ultrasound was related to increased circulating levels of neopterin, and immunohistochemical localization of neopterin was observed in complex carotid lesions obtained from carotid endarterectomy in patients with SAP. These findings suggest that neopterin is an important biomarker of plaque instability in both coronary and carotid atherosclerotic lesions. [6][7][8][9][10][11][12][13][14][15][16][17][18] . In this review, we focus on the relationship between neopterin and plaque instability in coronary and carotid arteries, and also introduce the results of our recent studies.

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Inflammation as a possible link between coronary and carotid plaque instability

Cited by 71 publications

References 0 publications

Progression of Carotid Stenosis Detected by Duplex Ultrasonography Predicts Adverse Outcomes in Cardiovascular High-Risk Patients

Progression of Carotid Stenosis Detected by Duplex Ultrasonography Predicts Adverse Outcomes in Cardiovascular High-Risk Patients

Early onset of subclinical atherosclerosis in women with gestational diabetes mellitus

Neopterin and Atherosclerotic Plaque Instability in Coronary and Carotid Arteries

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