“…With a new anti-inflammatory focus, studies have demonstrated a drastic reduction in leukocyte infiltration in the heart, fibrosis, circulating inflammatory cytokines/chemokines and improvements in cardiac output ventricular functions in Chagas disease (Morris et al 1989, Leon et al 2003, Botoni et al 2007, Coelho dos , Paula-Costa et al 2010. Because of these results, new therapeutic targets based on statins, a lipid-modifying agent HMG-CoA, have emerged as a method to prevent cardiovascular diseases (Liao 2002, Cheng et al 2005, Mizuno et al 2011. The clinical benefits of statins are thought to be associated with their ability to reduce cholesterol synthesis, but the product of their enzymatic reaction, mevalonate, is also a precursor of cholesterol and many non-steroidal isoprenoid compounds.…”