Inflammation and intraocular pressure after the use of Healon® in intraocular lens surgery

Binkhorst, C.D.

doi:10.1016/s0146-2776(80)80031-0

Cited by 54 publications

(12 citation statements)

References 3 publications

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“…[8][9] Healon contributed to our postopera¬ tive IOP elevations, it did so despite our efforts to aspirate it at the end of the nonfiltering procedures. We have no evidence that the posterior cham¬ ber lens implant itself causes IOP control difficulties in either the early or later postoperative period.…”

Section: Complicationsmentioning

confidence: 99%

Extracapsular Cataract Extraction and Posterior Chamber Lens Implantation in Eyes With Preexisting Glaucoma

McGuigan¹,

Gottsch²,

Stark³

et al. 1986

Archives of Ophthalmology

141

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Section: Complicationsmentioning

confidence: 99%

Extracapsular Cataract Extraction and Posterior Chamber Lens Implantation in Eyes With Preexisting Glaucoma

McGuigan¹,

Gottsch²,

Stark³

et al. 1986

Archives of Ophthalmology

141

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“…These agents may enhance the postoperative pressure elevations (Binkhorts 1980;Percival 1982;Olivius & Thornburn 1985;Nzser et al 1986). …”

mentioning

confidence: 99%

The effect of Healon and timolol on early postoperative intraocular pressure after extracapsular cataract extraction with implantation of a posterior chamber lens

Anmarkrud

Bergaust

Bulie

1992

Acta Ophthalmologica

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In a prospective, randomized, masked study the effect of sodium hyaluronate (Healon) and timolol on the acute intraocular pressure rise after extracapsular cataract extraction with implantation of a posterior chamber lens were evaluated. Intraocular pressure was measured preoperatively and 3-6 h and 24 h postoperatively. When no timolol was used, a significant rise in intraocular pressure was observed at 3-6 h, whether or not Healon was aspirated. Timolol reduced the intraocular pressure rise, especially during the first 3-6 h after surgery. When timolol was not applied at the end of surgery, IOP exceeded 30 mmHg in 28% 3-6 h postoperatively, compared to only 4% when timolol was applied.

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“…27,41,42 Consequently, most surgeons wash out the substance from the eye after completing surgical procedures, to remove as much HA as possible. In addition, many studies 43,44 advise the use of low-molecular-weight HAs, since it is believed that their low viscosity also makes them easier to remove and thus less injurious to eye tissue.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyaluronan viscous materials on cell membrane electrical properties

Santini

Cametti

Formisano

et al. 1998

J. Biomed. Mater. Res.

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Hyaluronan [hyaluronic acid (HA)] has been implicated in various cellular processes such as proliferation, adhesion, migration, and differentiation. The secondary and tertiary structures of HA give it very important and unique viscoelastic properties. HA-composed materials are currently used intraocularly during ophthalmological surgery to facilitate surgical procedures and prevent tissue damage. To examine the effects of three viscous biomaterials composed of hyaluronan (Healon, IAL, and Biolon) used in ophthalmological surgery, the membrane electrical properties of the erythroleukemic K562 cell line exposed to these materials were investigated. Membrane conductivity, membrane permittivity, and the conductivity of the cytosol were evaluated using dielectric relaxation measurements in the radiofrequency range and fitting the experimental results to the general equations of the Maxwell-Wagner effect. The results demonstrate that while membrane permittivity and the conductivity of the cytosol are not significantly altered, the membrane conductivity of K562 cells exposed to all three biomaterials increases substantially and in a time-dependent manner with respect to untreated cells. These observations seem to indicate that hyaluronan perturbs ionic transport while it does not vary the type, quantity, or distribution of membrane components. In addition, the variations induced by these substances on the cell membrane are not dependent upon the molecular weight or on the biological origin of hyaluronan. These results may aid in elucidating the mechanisms involved in hyaluronan/cell membrane interaction and thus may provide a deeper understanding of the complications related to their use in ophthalmological surgery.

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Inflammation and intraocular pressure after the use of Healon® in intraocular lens surgery

Cited by 54 publications

References 3 publications

Extracapsular Cataract Extraction and Posterior Chamber Lens Implantation in Eyes With Preexisting Glaucoma

Extracapsular Cataract Extraction and Posterior Chamber Lens Implantation in Eyes With Preexisting Glaucoma

The effect of Healon and timolol on early postoperative intraocular pressure after extracapsular cataract extraction with implantation of a posterior chamber lens

Effects of hyaluronan viscous materials on cell membrane electrical properties

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