Infiltration of the Leptomeninges by Systemic Cancer

Olson, Madelyn E.

doi:10.1001/archneur.1974.00490320010002

Cited by 545 publications

(232 citation statements)

References 24 publications

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“…The phenomenon of gastro-intestinal metastases from breast carcinoma is recorded by Sung et al (1964), Graham & Goldman (1964) and Klein & Sherlock (1972) amongst others. However, most interesting in the present context is the report by Cormier et al (1980) of 33 patients with linitis plastica due to metastases from lobular carcinoma of the breast; they did not see any cases with a linitis plastica pattern resulting from ductal carcinoma which, they noted, produced discrete nodules.…”

Section: Clinical Seriesmentioning

confidence: 97%

A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast

Harris¹,

Howell²,

Chrissohou³

et al. 1984

Br J Cancer

336

185

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The metastatic sites of infiltrating duct (IDC) and infiltrating lobular carcinoma (ILC) have been compared using both clinical and autopsy data. The following statistically significant differences were found: Lung parenchymal metastases were more common in IDC. Bone trephine biopsies were more likely to be positive in ILC. Carcinomatous meningitis was associated almost exclusively with ILC. Peritoneal/retroperitoneal metastases of distinctive pattern occurred in ILC. There was often associated linitis plastica-like involvement of the stomach wall and diffuse infiltration of the uterus. Hydronephrosis was a common secondary phenomenon. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5

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Section: Clinical Seriesmentioning

confidence: 97%

A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast

Harris¹,

Howell²,

Chrissohou³

et al. 1984

Br J Cancer

336

185

View full text Add to dashboard Cite

show abstract

“…8 It is therefore advisable to repeat the test when there is a high index of suspicion and the first taps are negative. 12 In our case, the patient presented with a typical history and findings of CES. The MRI failed to show any pathology that could explain his symptoms.…”

Section: Discussionmentioning

confidence: 69%

Meningeal Carcinomatosis: A Rare Cause of Cauda Equina Syndrome

2003

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“…Most patients present with acute or subacute onset, while a small number of patients with primary tumors may be in chronic onset. Since cancer cells can move into the CSF and infiltrate the dura and the brain parenchyma, clinical evidence of the disease could appear as symptoms of meninges and brain parenchyma damage, [7] cranial nerve palsy and spinal nerve root symptoms. [8] The most frequent initial symptom is intracranial hypertension such as headache, nausea and vomit.…”

Section: Discussionmentioning

confidence: 99%

Meningeal carcinomatosis: a retrospective analysis of seventy-seven cases

Chu¹,

Lang²,

Sun³

et al. 2017

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Aim: Meningeal carcinomatosis is a special type of malignant tumor characterized by short survival and poor prognosis. In the present study, the authors aim to analyze the clinical, laboratory data and prognosis of meningeal carcinomatosis patients. Methods: The authors enrolled 77 cases of meningeal carcinomatosis from 2003 to 2013 in the First Hospital of Jilin University. The clinical data including age, gender, symptoms at onset, clinical manifestations, primary tumors and the laboratory data including cerebrospinal fluid (CSF), tumor markers as well as the imaging data were analyzed. The interval between the onset of primary tumor and the onset of central nervous symptoms, treatments and survival time were also analyzed. Results: The onset of meningeal carcinomatosis was usually acute (46.2%) or subacute (39.0%). The most frequent symptom at onset was intracranial hypertension (70.1%). Symptoms such as headache, vomit and high lumbar puncture intracranial pressure was observed in 56% of cases during the course of the disease. CSF abnormalities such as higher protein concentration (73.4%), more CSF pleocitosis (57.1%) and lower glucose levels (48.4%) were found in 95.3% of meningeal carcinomatosis patients. Non-contrast enhanced cerebral magnetic resonance imaging (MRI) showed that 13.2% patients had abnormal meningeal changes while in the enhancement scan 35.3% patients showed changes. The serum tumor markers increased in 84% of the patients. There were no differences regarding the mean survival between patients who received intrathecal chemotherapy and those who received brain radiotherapy or supportive treatment. Conclusion: The most common clinical manifestation of meningeal carcinomatosis is intracranial hypertension. The most common primary tumor is lung cancer, followed by gastric cancer and breast cancer. The linear enhancement of meningeal on the MRI scan is of great importance for the diagnosis of meningeal carcinomatosis. Key words:Meningeal carcinomatosis, cerebrospinal fluid, magnetic resonance imaging, therapy ABSTRACTArticle history:

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Infiltration of the Leptomeninges by Systemic Cancer

Cited by 545 publications

References 24 publications

A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast

A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast

Meningeal Carcinomatosis: A Rare Cause of Cauda Equina Syndrome

Meningeal carcinomatosis: a retrospective analysis of seventy-seven cases

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