Infiltrating Mast Cell–Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype

Majorini, Maria Teresa; Cancila, Valeria; Rigoni, Alice; Botti, Laura; Dugo, Matteo; Triulzi, Tiziana; Cecco, Loris De; Fontanella, Enrico; Jachetti, Elena; Tagliabue, Elda; Chiodoni, Claudia; Tripodo, Claudio; Colombo, Mario P.; Lecis, Daniele

doi:10.1158/0008-5472.can-19-3596

Cited by 39 publications

(41 citation statements)

References 46 publications

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“…Intriguingly, a mouse model which involved crossing C57BL/6 MMTV-PyMT mice with mast cell-deficient Wsh mice suggests mast cells may program the developmental circuitry of murine breast cancer cells to a luminal-like subtype by directly enhancing ESR1 transcription. This finding was supported by examination of human breast tumors [26]. Such mast cell-breast cancer cell crosstalk has also been speculated in patients with late-stage, chemotherapy-resistant inflammatory breast cancer as mast cells often resides in close proximity (≤5 µm) to cytokeratin + breast cancer cells [44].…”

Section: The Function Of Mast Cells In Malignant Breast Tumorsmentioning

confidence: 70%

“…A recent trend in the field has been to breed mast cell-deficient mice with strains engineered to develop spontaneous or oncogene-inducible tumors. This has fueled new discoveries that help map the role of mast cells in skin- and breast-derived cancers [ 20 , 26 ]. For example, in an HPV-induced squamous cell carcinoma (SCC) murine model with Mcpt5-Cre + R-DTA + mast cell-deficiency, mast cell status did not alter tumor growth or angiogenesis, contradicting an earlier study that used a c-Kit-dependent mast cell-deficiency model [ 19 , 20 ].…”

Section: The Mast Cell—tumor Controversymentioning

confidence: 99%

“…In a spontaneous Wsh-MMTV-PyMT breast cancer model, mast cell absence delayed onset of cytokeratin 5 + basal-like breast cancers. A lower tumor growth rate, reduced angiogenesis, and spread was observed in mast cell deficient compared with wild-type mice [ 26 , 45 ]. Moreover, mast cells have been implicated in promoting 4T1 and PyMT metastasis to bone and lung in part via the SCF/c-Kit-axis [ 46 ].…”

Section: The Function Of Mast Cells In Malignant Breast Tumorsmentioning

confidence: 99%

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Mast Cells and Skin and Breast Cancers: A Complicated and Microenvironment-Dependent Role

Hanes

Giacomantonio

Marshall

2021

Cells

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Mast cells are important sentinel cells in host defense against infection and major effector cells in allergic disease. The role of these cells in cancer settings has been widely debated. The diverse range of mast cell functions in both immunity and tissue remodeling events, such as angiogenesis, provides multiple opportunities for mast cells to modify the tumor microenvironment. In this review, we consider both skin and breast cancer settings to address the controversy surrounding the importance of mast cells in the host response to tumors. We specifically address the key mediators produced by mast cells which impact tumor development. The role of environmental challenges in modifying mast cell responses and opportunities to modify mast cell responses to enhance anti-tumor immunity are also considered. While the mast cell’s role in many cancer contexts is complicated and poorly understood, the activities of these tissue resident and radioresistant cells can provide important opportunities to enhance anti-cancer responses and limit cancer development.

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Section: The Function Of Mast Cells In Malignant Breast Tumorsmentioning

confidence: 70%

Section: The Mast Cell—tumor Controversymentioning

confidence: 99%

Section: The Function Of Mast Cells In Malignant Breast Tumorsmentioning

confidence: 99%

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Mast Cells and Skin and Breast Cancers: A Complicated and Microenvironment-Dependent Role

Hanes

Giacomantonio

Marshall

2021

Cells

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“…The protumoral and antitumoral role of mast cells in BC progression is still controversial 31 . Studies showed that mast cells increased BC growth and metastasis 32 , but the study by della Rovere et al revealed that peritumoral mast cells seemed to have a cytolytic activity against tumor cells 33 .…”

Section: Discussionmentioning

confidence: 99%

Expression and Clinical Significance of Origin Recognition Complex Family in Breast Cancer

Chen

Jin

Xin

et al. 2021

Preprint

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BackgroundThe aim of this study is to investigate the potential clinical and prognostic value, role and driving molecular mechanisms of the origin recognition complex family in breast cancer.Resultsata from Oncomine, TCGA, GEO and ULCAN showed that ORC1L and ORC6L were highly expressed in breast cancer tissues, while the expression of ORC5L was inconsistent and there was no significant difference in the expression of ORC2L, ORC3L and ORC4L. High expression of ORC1L and ORC6L were mainly Her2 overexpressed subtype, and their expression were negatively correlated with patient age and positively correlated with tumor size, but not with lymph node metastasis, distant metastasis, or tumor stage. Expression of ORC5L was also negatively correlated with age and positively correlated with lymph node metastasis, but not with breast cancer molecular subtype and tumor size. Expression of ORC1L and ORC5L had high diagnostic value, and ORC6L had the highest diagnostic value in breast cancer. ORC6L was an independent poor prognostic factor for overall survival of breast cancer patients. It was involved in cell cycle progression, cell senescence, epigenetic regulation and other biological functions, and may regulate signaling pathways such as NF-KB, TP53 and WNT in breast cancer. We also found that the expression of ORC6L was related to the increased infiltration of Th1/2 cell and Treg cell, and decreased infiltration of Mast cell and NK cell.ConclusionsORC1L and ORC6L are highly expressed in breast cancer tissues, of which ORC6L has high diagnostic value and is an independent poor prognostic factor for overall survival of breast cancer patients. ORC6L may be involved in the occurrence and progression of breast cancer by regulating cell cycle progression, promoting the activation of cancer signaling pathways, and influencing tumor immune cells infiltration.

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“…Moreover, an in vitro animal experiment showed that coinjection of mast cells and HER2-positive breast cancer cells increased tumor engraftment and outgrowth in mice. [33] Additionally, a high level of mast cells in extratumoral benign prostate tissues was considered a risk factor for a poor prognosis in prostate cancer patients. [34] Mechanistically, it was observed that tumor-derived microvesicles from non-small-cell lung cancer (NSCLC) cells are internalized by mast cells, which enhances the migratory ability of mast cells and promotes the release of TNF-alpha and MCP-1.…”

Section: Discussionmentioning

confidence: 99%

A Novel Potential Diagnostic and Prognostic Biomarker for Esophageal Cancer

Miao¹,

Xie²,

Xu³

et al. 2021

Preprint

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Background: Esophageal cancer (EC) is a lethal malignancy of the digestive tract with high morbidity and mortality rates, lacking molecular biomarkers for EC diagnosis and prognosis with high specificity and sensitivity.Methods: Downloaded from the Cancer Genome Atlas (TCGA), the high-throughput transcriptome sequencing mRNA data was normalized, after which dysregulated genes were identified via limma package. Weight gene coexpression network analysis (WGCNA) was performed to select diagnostic modules and candidate genes. Later, Hub genes were screened through functional enrichment, LASSO Cox regression and survival analysis. Furthermore, we performed comparation with other biomarkers and investigated the association between our target gene and immune microenvironment.Results: Esophageal adenocarcinoma subtype and esophageal squamous cell carcinoma subtype displayed similar expression patterns in terms of differentially expressed genes, which indicates the existence of consensus biomarkers. After a series of analyses, including weighted gene coexpression network analysis, Gene Ontology enrichment analysis and Cox regression analysis, CMA1 was identified as an abnormally upregulated biomarker with highest diagnostic and prognostic potential. Moreover, CMA1 might exert its effect by influencing the immune microenvironment. Conclusion: CMA1 is a potential biomarker for EC in not only diagnosis but also prognosis. Future prospective clinic trials are expected to evaluate its performance in clinical practice.

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Infiltrating Mast Cell–Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype

Cited by 39 publications

References 46 publications

Mast Cells and Skin and Breast Cancers: A Complicated and Microenvironment-Dependent Role

Mast Cells and Skin and Breast Cancers: A Complicated and Microenvironment-Dependent Role

Expression and Clinical Significance of Origin Recognition Complex Family in Breast Cancer

A Novel Potential Diagnostic and Prognostic Biomarker for Esophageal Cancer

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