Infiltrating Carcinoma of the Bladder: Relation of Depth of Penetration of the Bladder Wall to Incidence of Local Extension and Metastases

Jewett, Hugh J.; Strong, George H.

doi:10.1016/s0022-5347(17)69924-5

Cited by 497 publications

(72 citation statements)

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“…To the best of our knowledge, this is the first study to assay and compare the ability to invade through the urothelial cell monolayer between bladder cancer cell types. In order for bladder cancer cells to invade the muscle layer, the cells are required to invade through the urothelial cell monolayer and the basement membrane (14). Transurothelial invasion mimics the invasion of bladder cancer cells through the urothelial cell monolayer.…”

Section: A B C D Ementioning

confidence: 99%

Invadopodia are essential in transurothelial invasion during the muscle invasion of bladder cancer cells

Imanishi

Yoneyama

Hatakeyama

et al. 2014

Molecular Medicine Reports

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Abstract. Muscle invasive bladder cancer is an aggressive type of epithelial tumor with a high rate of metastasis. For bladder cancer cells to reach the muscle layer, cells must invade through an urothelial cell monolayer (transurothelial invasion) and basement membrane. However, the process by which transurothelial invasion occurs has not been fully characterized. In this study we developed a novel method to evaluate the transurothelial invasion capacity and investigated its cellular and molecular processes using primary culture cells from bladder cancer patients. The analysis revealed that compared with the prognosis for patients with non-muscle invasive bladder cancer that of patients with muscle invasive bladder cancer was particularly poor due to metastatic recurrence. Cancer cells from patients with muscle invasive bladder cancer exhibited a higher invasive capacity through the urothelial cell monolayer compared with those from non-invasive bladder cancer patients. Furthermore, muscle invasive bladder cancer cells demonstrated a greater ability to form invadopodia, the filamentous actin-based membrane protrusions required for matrix degradation and invasion compared with non-invasive cells. Bladder cancer cell lines were established with reduced invadopodia formation by silencing the expression of cortactin, an essential component of invadopodia. The cortactin knockdown bladder cancer cells with reduced invadopodia formation demonstrated a markedly reduced ability to invade through the urothelial cell monolayer, indicating that invadopodia are essential for transurothelial invasion. The results indicate that invadopodia formation is required for muscle invasion of aggressive bladder cancer cells.

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Section: A B C D Ementioning

confidence: 99%

Invadopodia are essential in transurothelial invasion during the muscle invasion of bladder cancer cells

Imanishi

Yoneyama

Hatakeyama

et al. 2014

Molecular Medicine Reports

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“…Depth of invasion and the histological grading of the tumour are the factors best correlated to prognosis, but other indicators are still needed (Jewett & Strong, 1946;Mostofi, 1968;Kern, 1984;Tabbara & Mehio, 1984).…”

mentioning

confidence: 99%

Collagen IV staining pattern in bladder carcinomas: relationship to prognosis

Daher¹,

Abourachid²,

Bove³

et al. 1987

Br J Cancer

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A prospective study of type IV collagen in urothelial tissues was undertaken using an immunoperoxidase method on 125 ethanol fixed specimens. In normal and non cancerous urothelium, the basement membrane was continuously stained and the same pattern was seen in the 27 superficial carcinomas. In the 48 invasive bladder carcinomas, we observed two patterns of staining for collagen IV: in the first one, the staining line was conserved or partially fragmented (28 tumours), while in the second one the staining line was widely fragmented or absent in more than 5% of the tumour area (20 tumours). We found a highly significant statistical correlation between the pattern of staining and short term prognosis. Twenty-nine patients had an assessable follow-up of three years at least. All 16 patients with pattern I staining were alive at two years while only two out of 13 patients with pattern II staining survived two years (P less than 0.0001). At three years, all the patients with pattern II staining died while 11 patients with pattern I were still alive (P less than 0.001). These data provisionally indicate that the type IV collagen staining pattern may be of prognostic value in assessing the short term behaviour of invasive bladder carcinomas. It is thus logical to envisage that the treatment decisions may be influenced by the results of collagen IV staining. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10

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“…The clinical staging was performed according to the modified Jewett-Strong system (JEWETT & STRONG 1946): Stage A, tumour not invading beyond the lamina propria; Stage B, invasion of the muscle; Stage C, perivesical invasion, with a palpable but movable extravesical mass (includes prostatic invasion); Stage D, tumour fixed to the pelvic side wall.…”

Section: Methodsmentioning

confidence: 99%