Collagen IV staining pattern in bladder carcinomas: relationship to prognosis

Daher, N.; Abourachid, H; Bove, N.; Petit, Jacques; Burtin, P

doi:10.1038/bjc.1987.136

Cited by 51 publications

(20 citation statements)

References 34 publications

(39 reference statements)

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“…This result also suggests that CB plays a role in tumour invasion and metastasis. In the past, many investigations have shown close relationship between the distribution of BM antigens, the incidence of distant metastasis and patient survival times (Foster et al 1984;Daher et al 1987). Nakajima (1991) has also showed that discontinuous pattern of CIV was associated with lymph node metastasis and with shorter survival times in lung adenocarcinoma.…”

Section: Resultsmentioning

confidence: 98%

Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis

Sukoh

Abe

Nakajima

et al. 1994

Vichows Archiv A Pathol Anat

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The distributions of cathepsin B (CB) a lysosomal cysteine proteinase, type IV collagen (CIV) and laminin (LM), which are main components of basement membranes (BMs) were studied in a series of 64 human lung adenocarcinomas using an immunohistochemical technique. Over-expression of CB (> 80% positive cells) was significantly associated with the grade of tumour differentiation (p < 0.01), with lymph node metastasis (p < 0.01) and with BM degradation (p < 0.01) detected by the staining pattern of CIV and LM. It was significantly associated with a prognostic disadvantage (p < 0.01). The immunohistochemical staining pattern of CB has a close relationship with degradation of BM, and may be used as a marker for tumour metastasis and prognosis in lung adenocarcinoma.

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Section: Resultsmentioning

confidence: 98%

Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis

Sukoh

Abe

Nakajima

et al. 1994

Vichows Archiv A Pathol Anat

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“…Previously, the integrity of the UBM was demonstrated using polyclonal and monoclonal antibodies to type IV collagen and/or laminin and was used to establish a relationship between superficial and invasive transitionalcell carcinomas, the latter often being associated with the loss of basement membrane staining [4,15,20]. Normally the UBM is continuous, with colocalization of type IV collagen and/or laminin occuring in normal and nonmalignant inflammation specimens [2,5], although an unspecified, indistinct staining pattern was found in 1 of 17 normals associated with inflammatory infiltrates in an earlier study [4]. The p53 protein, a cellular phosphoprotein thought to take part in the regulation of cell proliferation and a marker of transitional-cell carcinoma, was correlated with breaks in the UBM detected by laminin and type IV collagen staining and with the presence of the carcinoma [17].…”

Section: Discussionmentioning

confidence: 99%

Extracellular matrix and integrin composition of the normal bladder wall

et al. 1996

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We performed an immunohistochemistry study of the normal human bladder so as to understand the interactions of extracellular matrix (ECM) components and the integrins of cell adhesion that accommodate the volume changes and maintain an impermeable barrier to reabsorption of urine in the bladder. The normal human urothelial cell and/or its plasma membrane contained integrins 0~3, c~V, [31, and [34 but did not contain integrin [33. The urothelial basement membrane (UBM) contained collagen type IV and laminin. Fibronectin and integrins (x3 and [~4 were found in or near the U B M area, with types I and III collagen and tenascin abutting the area. The patterns of collagen, laminin, tenascin, vitronectin, fobronectin, and the 0~3, c~V, [31, and [33 integrins in the lamina propria, vessels, nerves, and smooth-muscle layers are described. These findings detail the normal anatomical ECM/integrin relationship that provides the cellular basis for bladder-wall relationships responsible for its impermeable state and other functions.The relationship of the cellular adhesion mechanisms that help secure the urothelial cells to one another as well as to the underlying urothelial basement membrane (UBM) and extracellular matrix (ECM) components would be expected to contribute to the integrity of the impermeable bladder surface. This adhesion involves a family of celladhesion receptors called integrins, heterodimeric molecules expressed on cell surfaces [3]. The family is composed of at least 13 c~ chains and 8 [3 chains which, depending upon pairing, form heterodimers that recognize one or more ligands present on E C M or on opposing cell surfaces. Only limited information is known about the nature of the integrins or their E C M ligands that perform as the adhesion molecules in the bladder wall.The bladder wall of patients with interstitial cystitis, as characterized by varying degrees of chronic inflammaCorrespondence to:

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“…9 We studied BM expression in bladder carcinomas to evaluate its use for the histopathologic identification of microinvasion. Furthermore, this study was performed to assess the usefulness of BM staining in comparison with grading, staging, and ploidy for the prediction of the biological behavior of bladder tumors.…”

Section: He Rapidly Increasing Knowledge In Molecularmentioning

confidence: 99%

Prognostic significance of type IV collagen and laminin immunoreactivity in urothelial carcinomas of the bladder

Schapers

Pauwels²,

Havenith³

et al. 1990

Cancer

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Invasion of a carcinoma involves the degradation and penetration of the subepithelial basement membrane (BM). This phenomenon might be used for histopathologic evaluation of neoplasms of the bladder. The authors studied the clinicopathologic data and tissue specimens of 125 cases of urothelial carcinomas collected prospectively. Penetration of the BM was evaluated by immunohistochemical staining of the BM components laminin and type IV collagen. The use of this parameter as a prognostic indicator in bladder cancer was assessed. The 5-year survival rate of patients having tumors with an interrupted or absent BM was significantly lower than that of patients having tumors with an intact BM. The rate of progression was greater in tumors with an interrupted or absent BM than in tumors with an intact BM. No association was found between BM status and recurrence. However, a significant correlation between tumor stage and BM staining was found. A correlation was also found between ploidy and BM staining as well as between histologic grade and BM staining pattern. When evaluating histologic grade, stage, ploidy, age, and BM score as prognostic parameters, the stage of bladder carcinomas turned out to be the most important factor in predicting the survival rate and the progression-free survival. However, BM staining was found to be of value for early identification of microinvasion and is helpful for correct staging of urothelial carcinomas.

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Collagen IV staining pattern in bladder carcinomas: relationship to prognosis

Cited by 51 publications

References 34 publications

Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis

Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis

Extracellular matrix and integrin composition of the normal bladder wall

Prognostic significance of type IV collagen and laminin immunoreactivity in urothelial carcinomas of the bladder

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