Infertility treatments during pregnancy and the risk of autism spectrum disorder in the offspring

Davidovitch, Michael; Chodick, Gabriel; Shalev, Varda; Eisenberg, V. H.; Dan, Uzi; Reichenberg, Abraham; Sandin, Sven; Levine, Stephen Z.

doi:10.1016/j.pnpbp.2018.05.022

Cited by 23 publications

(21 citation statements)

References 32 publications

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“…Based on the analysis of the potential risk factors associated with assisted reproductive techniques, only a correlation between one type of technique (the transfer of frozen embryos) and speech delay was demonstrated, which had not been previously described [40]. Similarly, the study of the Israeli population did not show the effect of in vitro fertilization on the development of ASD compared with the control group of naturally conceived children [37]. Therefore, further prospective, large and high-quality studies are still required.…”

Section: Discussionmentioning

confidence: 80%

“…Moreover, a statistically significantly increased risk of ASD was found in children of mothers treated with progesterone due to conception problems. Progesterone exposure during the critical period of fetal life elevated the risk of ASD, possibly reflecting an epigenetic modification [37]. On the contrary, Lyan et al in their population study observed no correlation between the pre-gravid use of oral contraceptives and the risk of ASD in offspring.…”

Section: Discussionmentioning

confidence: 86%

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Preconception Risk Factors for Autism Spectrum Disorder—A Pilot Study

Hankus

Kazek²,

Paprocka

et al. 2020

Brain Sciences

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder of multifactorial etiology. Preconception risk factors are still poorly understood. A survey on preconception risk factors for ASD was conducted among parents of 121 ASD patients aged 3–12 years and parents of 100 healthy children aged 3–12 years. The exclusion criteria were as follows: the presence of associated problems such as intellectual disability, epilepsy or other genetic and neurological diseases. Thirteen parameters were considered, a few among which were conception problems, conception with assisted reproductive techniques, the use and duration of oral contraception, the number of previous pregnancies and miscarriages, time since the previous pregnancy (in months), the history of mental illness in the family (including ASD), other chronic diseases in the mother or father and maternal and paternal treatment in specialist outpatient clinics. Three factors statistically significantly increased the risk of developing ASD: mental illness in the mother/mother’s family (35.54% vs. 16.0%, p = 0.0002), maternal thyroid disease (16.67% vs. 5.0%, p = 0.009) and maternal oral contraception (46.28% vs. 29.0%, p = 0.01). Children of mothers with thyroid disorders or with mental illness in relatives should be closely monitored for ASD. Further studies are warranted to assess a potential effect of oral contraception on the development of offspring.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 86%

Preconception Risk Factors for Autism Spectrum Disorder—A Pilot Study

Hankus

Kazek²,

Paprocka

et al. 2020

Brain Sciences

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“…One such study using large registry data found that progesterone treatment rather than other hormonal exposures increased autism risk. 15 Other studies have also evaluated the effects of ICSI, as it is becoming increasingly common for the treatment of male factor infertility. In fact, its use in the United States has increased from 36.4% in 1996 to 76.2% in 2018, with the largest increase among cycles without male factor infertility.…”

Section: Heterogeneous Treatmentsmentioning

confidence: 99%

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?

Yeung¹,

Kim²,

Purdue-Smithe³

et al. 2018

Semin Reprod Med

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Concerns remain about the health of children conceived by infertility treatment. Studies to date have predominantly not identified substantial long-term health effects after accounting for plurality, which is reassuring given the increasing numbers of children conceived by infertility treatment worldwide. However, as technological advances in treatment arise, ongoing studies remain critical for monitoring health effects. To study whether the techniques used in infertility treatment cause health differences, however, remains challenging due to identification of an appropriate comparison group, heterogeneous treatment, and confounding by the underlying causes of infertility. In fact, the factors that are associated with underlying infertility, including parental obesity and other specific male and female factors, may be important independent factors to consider. This review will summarize key methodological considerations in studying children conceived by infertility treatment including the evidence of associations between underlying infertility factors and child health.

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“…There is evidence that parents of children with ASD are more likely to have infertility compared with parents of children without ASD. Therefore, infertility treatments may be affected for ASD [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Other study by Schieve et al [ 11 ] in 2017 in the United States (US) showed that ASD was not associated with ART or non-ART infertility treatments. Davidovitch et al [ 6 ] reported that IVF treatment compared with spontaneous conception was not statistically significantly associated with the risk of ASD among children. However, the results of studies are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study

et al. 2020

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Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication.Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children.Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2–10 years without ASD, while the cases were women with a child aged 2–10 years with ASD. We used a researcher-made questionnaire. Data were analyzed using Stata ver. 14 at the 0.05 significance level.Results: In the univariate analysis, there was significant association between child sex, delivery mode, history of preterm delivery, history of using ART, and maternal age at child’s birth and the risk of ASD. After the adjustment for other variables, this association was significant for male sex (2.66; 95% confidence interval [CI], 1.11–4.31; P=0.001) and history of using ART (4.03; 95% CI, 1.76–9.21; <i>P</i>=0.001). Therefore, after the adjustment for confounder variables, there was no significant association between ART and the risk of ASD among children (4.98; 95% CI, 0.91–27.30; <i>P</i>=0.065).Conclusion: After the adjustment for other variables, risk factors for ASD were male sex and history preterm delivery. Thus, there was no significant association between ART and the risk of ASD among children.

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Infertility treatments during pregnancy and the risk of autism spectrum disorder in the offspring

Cited by 23 publications

References 32 publications

Preconception Risk Factors for Autism Spectrum Disorder—A Pilot Study

Preconception Risk Factors for Autism Spectrum Disorder—A Pilot Study

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?

Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study

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