Infertility as a risk factor for breast cancer: Results from a hospital-based case–control study

Andarieh, Maryam Ghanbari; Delavar, Mouloud Agajani; Moslemi, Dariush; Ahmadi, Mahmoud Haji; Zabihi, Ebrahim; Esmaeilzadeh, Sedighe

doi:10.4103/jcrt.jcrt_905_16

Cited by 6 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reproductive factors included age at menarche, parity, age at first birth, breastfeeding and menopausal status. The earlier age of menarche (≤12 years) was associated with a statistically significant higher BrCa risk (OR = 1.18, 95% CI: 1.07 to 1.31, p = 0.0016), as shown in the meta-analysis of 29 studies [ 26 , 27 , 30 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 43 , 44 , 47 , 48 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 57 , 58 , 61 , 62 , 64 , 66 ]. In addition, analysis of 30 studies of parity [ 26 , 27 , 30 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 42 , 43 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 57 , 58 ,…”

Section: Resultsmentioning

confidence: 84%

“…What is more, the analysis of six studies [ 26 , 48 , 52 , 58 , 64 , 65 ] showed a statistically significant higher risk of BrCa in women giving birth for the first time after 30 than before the age of 30 (OR = 3.08, 95% CI: 1.10 to 8.60, p = 0.0322). Beyond the aforementioned, in the meta-analysis of 27 studies [ 26 , 29 , 30 , 32 , 33 , 36 , 37 , 38 , 39 , 41 , 43 , 44 , 45 , 46 , 47 , 48 , 50 , 51 , 52 , 54 , 58 , 61 , 62 , 64 , 65 , 66 , 67 ], non-breastfeeding was associated with a significant increase in the risk for BrCa, in comparison to breastfeeding (OR = 1.36, 95% CI: 1.13 to 1.63, p = 0.0010). Finally, the data from 22 studies [ 26 , 32 , 34 , 35 , 36 , 37 , 39 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 50 , 52 , 54 , 55 ,…”

Section: Resultsmentioning

confidence: 99%

“…Among personal risk factors, the meta-analysis for BMI based on 16 studies [ 26 , 27 , 28 , 29 , 32 , 34 , 39 , 41 , 44 , 49 , 51 , 54 , 55 , 57 , 63 , 66 ] indicated a non-significant increase in risk for obese women (OR = 1.19, 95% CI: 0.95 to 1.50, p = 0.1289) compared to women who are underweight/normal/overweight. Tobacco use also had significant associations with BrCa risks (OR = 1.52, 95% CI: 1.26 to 1.83, p = 0.0000) based on the meta-analysis of 14 studies [ 26 , 28 , 29 , 30 , 36 , 42 , 49 , 52 , 54 , 58 , 62 , 64 , 66 , 67 ]. Likewise, 29 studies [ 27 , 28 , 29 , 30 , 32 , 33 , 34 , 35 , 37 , 39 , 41 , 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 54 , 55 ,…”

Section: Resultsmentioning

confidence: 99%

“…Tobacco use also had significant associations with BrCa risks (OR = 1.52, 95% CI: 1.26 to 1.83, p = 0.0000) based on the meta-analysis of 14 studies [ 26 , 28 , 29 , 30 , 36 , 42 , 49 , 52 , 54 , 58 , 62 , 64 , 66 , 67 ]. Likewise, 29 studies [ 27 , 28 , 29 , 30 , 32 , 33 , 34 , 35 , 37 , 39 , 41 , 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 54 , 55 , 57 , 58 , 61 , 63 , 64 , 66 , 67 ] showed that family history of BrCa in the first or second relatives was significantly associated with higher risk (OR = 1.72, 95% CI: 1.32 to 2.24, p = 0.0001). Finally, an analysis of four studies [ 26 , 29 , 32 , 39 ] found a slightly increased, but not statistically significant, risk of BrCa in women with diabetes (OR = 1.99, 95% CI: 0.60 to 6.62, p = 0.2605).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

Barańska

Błaszczuk

Kanadys³

et al. 2021

Cancers

View full text Add to dashboard Cite

To perform a meta-analysis of case-control studies that addressed the association between oral contraceptive pills (OC) use and breast cancer (BrCa), PubMED (MEDLINE), Embase, and the Cochrane Library were searched to identify case-control studies of OC and BrCa published between 2009 and 2020. We used the DerSimonian–Laird method to compute pooled odds ratios (ORs) and confidence intervals (CIs), and the Mantel–Haenszel test to assess the association between OC use and cancer. Forty-two studies were identified that met the inclusion criteria and we included a total of 110,580 women (30,778 into the BrCa group and 79,802 into the control group, of which 15,722 and 38,334 were using OC, respectively). The conducted meta-analysis showed that the use of OC was associated with a significantly increased risk of BrCa in general, OR = 1.15, 95% CI: 1.01 to 1.31, p = 0.0358. Regarding other risk factors for BrCa, we found that increased risk was associated significantly with early menarche, nulliparous, non-breastfeeding, older age at first parity, postmenopause, obesity, smoking, and family history of BrCa. Despite our conclusion that birth control pills increase the cancer risk being supported by extensive previous studies and meta-analyzes, further confirmation is required.

show abstract