Inferring recent human phylogenies using forensic STR technology

Rowold, Diane J.; Herrera, René J.

doi:10.1016/s0379-0738(03)00073-2

Cited by 45 publications

(33 citation statements)

References 23 publications

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“…These attributes endow them with the high resolution necessary to assess phylogenetic relationships among closely related human groups. [26][27][28][29] Although several studies related to the Tibetan population utilizing autosomal markers have been previously published, [30][31][32][33][34][35] the current project is the first of its kind to perform comprehensive phylogenetic analyses in a statistically significant sample size. A set of 15 autosomal STR loci was employed to characterize three populations from Nepal (Newar, Tamang and Kathmandu) as well as the general populace from Tibet.…”

Section: Introductionmentioning

confidence: 99%

Genetic insights into the origins of Tibeto-Burman populations in the Himalayas

et al. 2009

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The Himalayan mountain range has played a dual role in shaping the genetic landscape of the region by (1) delineating east-west migrations including the Silk Road and (2) restricting human dispersals, especially from the Indian subcontinent into the Tibetan plateau. In this study, 15 hypervariable autosomal STR loci were employed to evaluate the genetic relationships of three populations from Nepal (Kathmandu, Newar and Tamang) and a general collection from Tibet. These Himalayan groups were compared to geographically targeted worldwide populations as well as Tibeto-Burman (TB) speaking groups from Northeast India. Our results suggest a Northeast Asian origin for the Himalayan populations with subsequent gene flow from South Asia into the Kathmandu valley and the Newar population, corroborating a previous Y-chromosome study. In contrast, Tamang and Tibet exhibit limited genetic contributions from South Asia, possibly due to the orographic obstacle presented by the Himalayan massif. The TB groups from Northeast India are genetically distinct compared to their counterparts from the Himalayas probably resulting from prolonged isolation and/or founder effects.

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Section: Introductionmentioning

confidence: 99%

Genetic insights into the origins of Tibeto-Burman populations in the Himalayas

et al. 2009

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“…They are used for a variety of applications including forensic identification, 1 phylogenetic reconstruction 2 and to monitor chimerism after allogeneic bone marrow transplantation for early diagnosis of graft failure or disease relapse. Allelic frequencies, allelic distribution pattern and level of heterozygosity of certain microsatellite markers has already been reported in various ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Developing an algorithm of informative markers for evaluation of chimerism after allogeneic bone marrow transplantation

Sellathamby

Balasubramanian

Sivalingam

et al. 2006

Bone Marrow Transplant

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Analysis of chimerism by polymerase chain reaction amplification of STR or VNTR has become a routine procedure for the evaluation of engraftment after allogeneic stem cell transplantation. Knowledge of the frequency of different STR or VNTR alleles in unrelated individuals in a population is useful for forensic work. In the context of HLA identical sibling bone marrow transplantation the informativeness of these markers needs to be evaluated. We evaluated five STRs (THO1, VWA, FES, ACTBP2, and F13A1) and 1 VNTR (APOB) for informativeness in stem cell transplants from HLA identical sibling donors. All four markers used individually allowed us to discriminate 20-56% of the patient donor pairs. Using a combination of all these markers along with a polymorphic marker in the b-globin gene and the sex chromosome specific amelogenin marker, we were able to discriminate 99% of the patient donor pairs. We have established an algorithm for evaluating chimerism following HLA identical sibling donor transplants in the Indian population using molecular markers in 310 patients. Analysis of heterozygote frequencies in different populations is similar suggesting that this algorithm can be used universally for transplant centers to evaluate chimerism following allogeneic bone marrow transplantation.

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“…40 Autosomal STRs are hypervariable markers that have proven to be useful in the elucidation of recent human evolution. 46 Their selective neutrality, widespread distribution throughout the genome, abundance, large number of alleles and high heterozygosity provide the high resolution necessary for assessing phylogenetic relationships among closely related human populations. [46][47][48][49][50] In addition, unlike the uniparental mtDNA and Y-chromosome haplotypes, STRs are biparentally derived, allowing for the assessment of a more representative genetic profile of the populations under scrutiny.…”

Section: Introductionmentioning

confidence: 99%