Inferior frontal gyrus seed-based resting-state functional connectivity and sustained attention across manic/hypomanic, euthymic and depressive phases of bipolar disorder

Yu, Hua; Li, Mingli; Meng, Yajing; Li, Xiaojing; Wei, Wei; Li, Yin-Fei; Li, Lei; Guo, Wanjun; Wang, Qiang; Deng, Wei; Ma, Xiaoyan; Coid, Jeremy; Li, Tao

doi:10.1016/j.jad.2020.12.199

Cited by 16 publications

(7 citation statements)

References 61 publications

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“…The present study showed that patients with LLD exhibited decreased sFC between the habenula and IFG, which is consistent with the disrupted FC between the habenula and the frontal cortex (middle frontal gyrus and frontal pole) in patients with MDD reported in previous studies 9,12 . The IFG is involved in the perception and interpretation of emotional stimuli, emotion regulation, empathy and emotional perspective‐taking, 25 and dysfunction of the IFG in patients with depression has been reported in previous studies 26 . Therefore, the decreased sFC between the habenula and IFG indicates a functional disconnection of these two important hubs of emotion regulation in patients with LLD.…”

Section: Discussionsupporting

confidence: 92%

“… 9 , 12 The IFG is involved in the perception and interpretation of emotional stimuli, emotion regulation, empathy and emotional perspective‐taking, 25 and dysfunction of the IFG in patients with depression has been reported in previous studies. 26 Therefore, the decreased sFC between the habenula and IFG indicates a functional disconnection of these two important hubs of emotion regulation in patients with LLD. Additionally, the decreased sFC between the habenula and IFG was negatively associated with the severity of depressive symptoms (especially psychomotor retardation) but not cognitive bias, anxiety/somatization, sleep disturbance or weight, which provides more detailed information about the aspect of depressive symptoms affected by habenular FC.…”

Section: Discussionmentioning

confidence: 99%

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Disrupted functional connectivity of the habenula links psychomotor retardation and deficit of verbal fluency and working memory in late‐life depression

Su,

Chen,

Yang

et al. 2023

CNS Neurosci Ther

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BackgroundFunctional abnormalities of the habenula in patients with depression have been demonstrated in an increasing number of studies, and the habenula is involved in cognitive processing. However, whether patients with late‐life depression (LLD) exhibit disrupted habenular functional connectivity (FC) and whether habenular FC mediates the relationship between depressive symptoms and cognitive impairment remain unclear.MethodsOverall, 127 patients with LLD and 75 healthy controls were recruited. The static and dynamic FC between the habenula and the whole brain was compared between LLD patients and healthy controls, and the relationships of habenular FC with depressive symptoms and cognitive impairment were explored by correlation and mediation analyses.ResultsCompared with the controls, patients with LLD exhibited decreased static FC between the right habenula and bilateral inferior frontal gyrus (IFG); there was no significant difference in dynamic FC of the habenula between the two groups. Additionally, the decreased static FC between the right habenula and IFG was associated with more severe depressive symptoms (especially psychomotor retardation) and cognitive impairment (language, memory, and visuospatial skills). Last, static FC between the right habenula and left IFG partially mediated the relationship between depressive symptoms (especially psychomotor retardation) and cognitive impairment (verbal fluency and working memory).ConclusionsPatients with LLD exhibited decreased static FC between the habenula and IFG but intact dynamic FC of the habenula. This decreased static FC mediated the relationship between depressive symptoms and cognitive impairment.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Disrupted functional connectivity of the habenula links psychomotor retardation and deficit of verbal fluency and working memory in late‐life depression

Su,

Chen,

Yang

et al. 2023

CNS Neurosci Ther

Self Cite

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“…This difference may be related to the compensatory mechanism described above and, on the other hand, to the variation in depression and anxiety in the included population. Anxiety and depression were found to affect the FC of IFG and brain regions in DMN (Fang et al, 2016;Yan et al, 2019;Yu et al, 2021). Therefore, it is difficult to determine whether insomnia or anxiety and depression had a greater impact Analysis of the correlation between the FC changes and PSQI improvement in all subjects.…”

Section: Discussionmentioning

confidence: 99%

The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation

et al. 2023

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BackgroundInsomnia disorder (ID) seriously affects the quality of people’s daily life, and acupuncture is an effective therapy for it. As an essential component of the upward activation system, the locus coeruleus (LC) plays a crucial role in sleep–wake regulation, its aberrant functional connectivity (FC) is found to be involved in ID. The purpose of this study was to explore the modulation effect of acupuncture on the resting state FC of LC in ID patients.Methods60 ID patients were recruited and randomly assigned to real acupuncture (RA) or sham acupuncture (SA) treatment. Resting-state functional magnetic resonance imaging (fMRI) data were collected before and after the treatment. With LC as the region of interest, the FC method was adopted to examine acupuncture-related modulation of intrinsic connectivity in ID patients. The Pittsburgh Sleep Quality Index (PSQI), Hyperarousal Scale (HAS), and actigraphy were used to assess sleep quality and cortical hyperarousal states. Associations between clinical outcomes and FC features were calculated using Pearson’s correlation analysis.ResultsThe improvement in sleep quality and hyperarousal in the RA group was greater than that in the SA group. After treatment, the FC between the LC and left inferior frontal gyrus (IFG) decreased in the RA group. The FC between the LC and left insula and supramarginal gyrus (SMG) was higher in the RA group. The change of LC FC values with the SMG was negatively associated with the change in PSQI scores.ConclusionAcupuncture can modulate FC between the LC and IFG, insular gyrus, and SMG. This may imply the potential mechanism of acupuncture treatment for insomnia.

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“…PD patients suffer from depression and tremor may be associated with the abnormal connectivity within the pathological interaction between the basal ganglia and cerebello-thalamo-cortical circuit (Lewis et al, 2011 ). Zeng et al found significant decreased in GM volume in the cerebellar Crus I, Vermis III and VIII in PD patients, demonstrated that cerebellar GM atrophy may also be involved in PD cognitive impairment severity (Zeng et al, 2017 ). For the right cerebellar Crus I, in addition to a possibility of pathophysiological change, the increased GM volume may be a compensation for basal ganglia dysfunction to maintain motor function at a near normal level (Lewis et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Voxel-based morphometry of grey matter structures in Parkinson’s Disease with wearing-off

Zhai,

Fan,

Xiao

et al. 2023

Brain Imaging and Behavior

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Our study aimed to investigate the grey matter (GM) changes using voxel-based morphometry (VBM) in Parkinson’s disease (PD) patients with wearing-off (WO). 3D-T1-weighted imaging was performed on 48 PD patients without wearing-off (PD-nWO), 39 PD patients with wearing-off (PD-WO) and 47 age and sex-matched healthy controls (HCs). 3D structural images were analyzed by VBM procedure with Statistical Parametric Mapping (SPM12) to detect grey matter volume. Widespread areas of grey matter changes were found in patients among three groups (in bilateral frontal, temporal lobes, lingual gyrus, inferior occipital gyrus, right precuneus, right superior parietal gyrus and right cerebellum). Grey matter reductions were found in frontal lobe (right middle frontal gyrus, superior frontal gyrus and precentral gyrus), right parietal lobe (precuneus, superior parietal gyrus, postcentral gyrus), right temporal lobe (superior temporal gyrus, middle temporal gyrus), bilateral lingual gyrus and inferior occipital gyrus in PD-WO group compared with the PD-nWO group. Our results suggesting that wearing-off may be associated with grey matter atrophy in the cortical areas. These findings may aid in a better understanding of the brain degeneration process in PD with wearing-off.

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Inferior frontal gyrus seed-based resting-state functional connectivity and sustained attention across manic/hypomanic, euthymic and depressive phases of bipolar disorder

Cited by 16 publications

References 61 publications

Disrupted functional connectivity of the habenula links psychomotor retardation and deficit of verbal fluency and working memory in late‐life depression

Disrupted functional connectivity of the habenula links psychomotor retardation and deficit of verbal fluency and working memory in late‐life depression

The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation

Voxel-based morphometry of grey matter structures in Parkinson’s Disease with wearing-off

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