Infective right atrial thrombus: a rare complication of total parenteral nutrition in an adult

Badano, Luigi P.; Carratino, L; Giunta, Luca; Calisi, Pasqualina; Lucatti, A

doi:10.1093/oxfordjournals.eurheartj.a060082

Cited by 6 publications

(1 citation statement)

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“…20 Although our observational study does not elucidate underlying mechanisms accounting for these sex differences, recent studies have suggested that myocyte hypertrophy due to an increase in aortic stiffness and enhanced afterload in older subjects may account for an age-dependent increase in LVEF. 5,[21][22][23] Furthermore, a progressive myocyte loss in aged men, but not in women, was observed in a postmortem analysis and may account for the sex differences in LV function. 24 Reduced testosterone levels and reduced physical activity in older men have been suggested to account for these findings.…”

Section: Discussionmentioning

confidence: 87%

Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry

Gebhard

Marędziak

Messerli

et al. 2020

European Heart Journal - Cardiovascular Imaging

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Aims There are significant sex-specific differences in left ventricular ejection fraction (LVEF), with a higher LVEF being observed in women. We sought to assess the clinical relevance of an increased LVEF in women and men. Methods and results A total of 4632 patients from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry (44.8% women; mean age 58.7 ± 13.2 years in men and 59.5 ± 13.3 years in women, P = 0.05), in whom LVEF was measured by cardiac computed tomography, were categorized according to LVEF (low <55%, normal 55–65%, and high >65%). The prevalence of high LVEF was similar in both sexes (33.5% in women and 32.5% in men, P = 0.46). After 6 years of follow-up, no difference in mortality was observed in patients with high LVEF in the overall cohort (P = 0.41). When data were stratified by sex, women with high LVEF died more often from any cause as compared to women with normal LVEF (8.6% vs. 7.1%, log rank P = 0.032), while an opposite trend was observed in men (5.8% vs. 6.8% in normal LVEF, log rank P = 0.89). Accordingly, a first order interaction term of male sex and high LVEF was significant (hazard ratios 0.63, 95% confidence intervals 0.41–0.98, P = 0.043) in a Cox regression model of all-cause mortality adjusted for age, cardiovascular risk factors, and severity of coronary artery disease (CAD). Conclusion Increased LVEF is highly prevalent in patients referred for evaluation of CAD and is associated with an increased risk of death in women, but not in men. Differentiating between normal and hyperdynamic left ventricles might improve risk stratification in women with CAD. Clinical trial registration https://clinicaltrials.gov/ct2/show/NCT01443637.

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Section: Discussionmentioning

confidence: 87%

Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry

Gebhard

Marędziak

Messerli

et al. 2020

European Heart Journal - Cardiovascular Imaging

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Massive septic thrombus formation on a superior vena cava indwelling catheter following Torulopsis (Candida) glabrata fungemia

et al. 2001

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Fungal endocarditis is an exceedingly rare complication of indwelling central venous catheters in adults. Here we describe what appears to be the first case of a right atrial thrombus superinfected with the yeast Torulopsis (Candida) glabrata and attached to an indwelling superior vena cava catheter that was not used for parenteral nutrition. A large vegetation-like mass adherent to the catheter tip was visualized by transesophageal echocardiography in a patient who presented with signs of septic pulmonary embolism. Following open-heart surgery, the definitive diagnosis was established by histopathologic examination of the surgical specimen.

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Management of complications in patients receiving home parenteral nutrition

Howard¹,

Ashley²

2003

Gastroenterology

181

115

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Infective right atrial thrombus: a rare complication of total parenteral nutrition in an adult

Cited by 6 publications

References 0 publications

Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry

Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry

Massive septic thrombus formation on a superior vena cava indwelling catheter following Torulopsis (Candida) glabrata fungemia

Management of complications in patients receiving home parenteral nutrition

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