INFECTIVE ENDOCARDITIS: TREATMENT AND PREVENTIVE MAINTENANCE (part III)

Белов, Б. С.; Тарасова, Г. М.

doi:10.14412/1996-7012-2008-501

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Другим важным клиническим синдромом являются гемодинамические нарушения, обусловленные клапанным поражением. Было установлено, что частота поражения аортального клапана в исследуемой группе составила 53% (95% ДИ 41,0-65,1), митрального -23% (95% ДИ 12,6-32,8), митрального и аортального одновременно -18% (95% ДИ 8,9-27,5), трикуспидального -6% (95% ДИ 0, [3][4][5][6][7][8][9][10][11]8). Частота и структура клапанного поражения не различались при сравнении пациентов с ИЭ в период до возникновения пандемии COVID-19 с пациентами, наблюдавшимися с 2020 г.…”

Section:  материалы и методыunclassified

“…В связи с увеличением количества разнообразных инвазивных диагностических и лечебных манипуляций, интенсивным развитием кардиохирургии, распространением потребления инъекционных наркотиков, повсеместным использованием в клинической практике антибактериальных препаратов, лечением глюкокортикостероидами и цитостатиками, а также по причине усовершенствования микробиологических и серологических методов исследования, позволяющих выявить в том числе редкие возбудители, ИЭ в настоящее время является полиэтиологичным заболеванием, спектр возбудителей которого постепенно расширяется [11]. В то же время в большинстве случаев сообщается о невысоком показателе положительного бактериологического исследования образцов крови -13% и лишь при использовании специальных флаконов -до 68,3%, что снижает диагностическую ценность критериев Duke для выявления заболевания [12].…”

Section:  материалы и методыunclassified

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Some Features of Infectious Endocarditis during the Pandemic COVID-19 Infection

Родина¹,

Корженевская²,

Гавриленко³

et al. 2023

Клиническая Инфектология И Паразитология

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Цель. Анализ клинических проявлений инфекционного эндокардита у пациентов, перенесших COVID-19-инфекцию. Материалы и методы. Проанализированы данные 66 пациентов с диагностированным инфекционным эндокардитом (ИЭ) в период с 2018 по 2022 г. в рамках обсервационного продольного с ретроспективным фрагментом исследования. Были выделены группы: перенесшие COVID-19-инфекцию и без COVID-19-инфекции, c первичным и вторичным ИЭ, с сопутствующими заболеваниями и без сопутствующей патологии. Далее проводились анализ и сопоставление групп по ключевым параметрам. Результаты. Установлено увеличение числа случаев ИЭ в течение анализируемого периода. С 2020 по 2022 г. в 25 случаях из 46 (54%, 95% ДИ 40,0–68,7) ИЭ был выявлен у подтвержденных реконвалесцентов после инфекции COVID-19. Не выявлено особенностей клинической картины ИЭ у пациентов, перенесших COVID-19-инфекцию. Преобладающими клиническими проявлениями были лихорадка, потливость, озноб. Среди выделенных при микробиологическом исследовании крови микроорганизмов 75% были грамположительными бактериями (n=9) с преобладанием семейства Enterococcaceae. Заключение. Повторная эхокардиография (ЭхоКГ) должна быть выполнена пациентам, перенесшим COVID-19-инфекцию, в том числе при отсутствии других очевидных показаний к данному исследованию. Для определения сроков и кратности повторной ЭхоКГ необходим анализ большой выборки пациентов с ИЭ. The purpose of the study is to analyze the clinical manifestations of infective endocarditis in patients who have had COVID-19 infection. Material and methods. We analyzed the data of 66 patients with infective endocarditis (IE) in the period from 2018 to 2022, this study – is an observational longitudinal with a retrospective fragment. Selective groups were followed: patient after COVID-19 infection and without COVID-19 infection, with primary and secondary IE, with comorbidities and without comorbidities. Further, the groups were analyzed and compared by key parameters. Results. We observed an increase in the number of cases of IE during the analyzed period. From 2020 to 2022, 25 out of 46 cases (54%, 95% CI 40.0–68.7) had IE in confirmed convalescents after COVID-19 infection. There were no features of the clinical picture of IE in patients who underwent COVID-19 infection. The predominant clinical manifestations were fever, sweating, chills. Among the microorganisms isolated during microbiological blood analysis, 75% were gram-positive bacteria (n=9), with a predominance of the Enterococcaceae family. Conclusion. Repeat echocardiography should be performed in patients who have had a previous COVID-19 infection, including in the absence of other obvious indications for this study. To determine the timing and frequency of repeated echocardiography, it is necessary to analyze a large sample of patients with IE.

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Section:  материалы и методыunclassified

Some Features of Infectious Endocarditis during the Pandemic COVID-19 Infection

Родина¹,

Корженевская²,

Гавриленко³

et al. 2023

Клиническая Инфектология И Паразитология

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Clinical case of complicated course of infectious endocarditis in a teenager

et al. 2022

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Infective endocarditis (IE) is a heart disease of an infectious nature with a primary lesion of the endocardium, heart valves, ligaments, followed by dissemination of the process to various organs. Infective endocarditis still remains a disease that is difficult to diagnose and unpredictable in terms of outcomes; it is registered in all countries of the world. Despite all the advances in medicine, infective endocarditis remains an extremely dangerous disease, with a mortality rate of 10–30%. The most common causes of lethal outcome of IE are multiple complications: embolisms of various localization, including cerebral arteries, aneurysms, toxic lesions of the spleen, myocarditis and pericarditis, acute renal failure. Currently, in pediatric cardiology practice, the frequency of primary infective endocarditis, which occurs with a change in the clinical picture, its atypical variants, has increased. The awareness of doctors of all specialties about this problem, the correct and timely diagnosis of the disease allows prescribing adequate therapy earlier and thereby improves the prognosis. The aim of our work was to familiarize physicians with the clinical observation of a teenager with an atypical onset of primary infective endocarditis, occurring under the “mask” of acute cerebrovascular accident. Also, the peculiarity of this case was the primary diagnosis of hereditary thrombophilia in the patient and the possible debut of a demyelinating disease of the central nervous system during the examination, which certainly complicated the diagnostic search and affected the outcome of infective endocarditis. The significance of dental procedures preceding the disease in a child, unfortunately, was not properly appreciated by the parents, but it is the inflammatory process in the oral cavity that should be considered as a key etiological factor in the development of infective endocarditis in this case.

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Clinical course and features of the diagnosis of infectious endocarditis in the elderly

Степченко

Мещерина

Хардикова

et al. 2022

Med. vestn. Ûga Ross.

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Infectious endocarditis is a formidable disease characterized by an extremely unfavorable prognosis in its natural course. Analyzing the literature data, it can be noted that the frequency of infectious endocarditis in the Russian Federation has relatively high prevalence rates in relation to other countries. Currently, the problem of early diagnosis of infectious endocarditis remains relevant. Despite the fact that the diagnosis of infectious endocarditis has improved, mainly as a result of the improvement of echocardiographic and microbiological approaches, the introduction of new antibacterial drugs and cardiac surgery technologies into clinical practice, the clinical picture, changes in laboratory parameters can lead to the exclusion of immuno-inflammatory, rheumatic, oncological, hematological diseases, complicating and delaying the diagnosis of infectious endocarditis. The first clinical signs of infectious endocarditis may be nonspecific, and the disease remains unrecognized for weeks or even months. The high frequency of thrombotic, thrombohemorrhagic complications indicates profound changes in the hemostasis system in infectious endocarditis and the need to disclose the pathogenesis of these disorders. The combination of these factors led to the late diagnosis of this disease in the patient. The aim of the study is to study the possibility of improving the results of diagnosis and therapy of patients with infectious endocarditis in clinical practice.

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INFECTIVE ENDOCARDITIS: TREATMENT AND PREVENTIVE MAINTENANCE (part III)

Cited by 3 publications

References 20 publications

Some Features of Infectious Endocarditis during the Pandemic COVID-19 Infection

Some Features of Infectious Endocarditis during the Pandemic COVID-19 Infection

Clinical case of complicated course of infectious endocarditis in a teenager

Clinical course and features of the diagnosis of infectious endocarditis in the elderly

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