Infective endocarditis: Surgical management and prognostic predictors

Moreira, Rita Ilhão; Cruz, Madalena Coutinho; Branco, Luísa Moura; Galrinho, A; Miranda, Luis; Fragata, José; Ferreira, Rui Cruz

doi:10.1016/j.repc.2017.08.007

Cited by 26 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most common indication for surgery was heart failure followed by prediction of peripheral embolism and uncontrolled infection. In our study surgery was associated with lower in hospital mortality in patients with surgical indication in agreement with the studies of Moreira et al and Leone et al [ 17 , 21 ].…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Systemic immune-inflammation index predicts mortality in infective endocarditis

Ağuş

Kahraman

Arslan

et al. 2020

Journal of the Saudi Heart Association

View full text Add to dashboard Cite

Objectives The aim of our study was to evaluate the usefulness of systemic immune-inflammation index (SII) at admission in predicting in-hospital mortality in patients with infective endocarditis. Methods 133 definite IE patients (≥18 years) according to modified Duke criteria, treated in our tertiary care hospital between December 2009 and May 2019, were retrospectively analysed. Symptoms, comorbidities, predisposing valvular diseases, prosthetic valve, device, history of injectable drug use, blood culture results, echocardiography findings, and complications were collected. We calculated the SII as follows: SII = platelet count × neutrophil count/lymphocyte count at admission. Results The median age of the patients was 56 (40–66) years. Prosthetic valve disease was the most frequent predisposing valve lesion. Staphylococcus species were the most common microorganisms. The most frequent complication was in-hospital mortality (22%) followed by renal failure. Older population, syncope, increased inflammatory markers, high systolic pulmonary artery pressure (PAPs), heart failure, renal failure, and septic shock were associated with high mortality. However age, syncope, hypocalcemia, not going to surgery, and SII were independent predictors of in-hospital mortality. According to receiver operating characteristic curve analysis, the optimal SII cut-off value for predicting mortality was 2314 (area under the curve 0.641; P = 0.019). Conclusion We demonstrated that high SII levels are independently associated with in-hospital mortality. The SII may be a promising prognostic predictor for patients with infective endocarditis.

show abstract

Section: Discussionsupporting

confidence: 93%

“…The median age of our patients was 58 (43–66) similarly to reports of developed countries [ 16 , 17 ]. In our study cohort 30 (22%) patients died during hospital stay.…”

Section: Discussionsupporting

confidence: 83%

Systemic immune-inflammation index predicts mortality in infective endocarditis

Ağuş

Kahraman

Arslan

et al. 2020

Journal of the Saudi Heart Association

View full text Add to dashboard Cite

show abstract

“…In a French study with 303 patients with left-sided endocarditis, Lung et al found a higher incidence of mitral valve compromise than of aortic (49.2 vs. 32.3%) [17]. At the opposite extreme, we find the results of the study by Ilhão Moreira et al; in a series of 233 patients followed for 8 years, they observed that aortic involvement was more frequent (55.7%) than mitral (38.2%) [21].…”

Section: Left-sided Endocarditis With Aortic Compromisesupporting

confidence: 61%

“…In that study, the frequency of indication for surgical treatment was analysed according to location. It was found that operations were performed in 64% of the cases of aortic endocarditis, while the percentage was only 31% in the cases of mitral endocarditis [21].…”

Section: Indication For Surgery In Left-sided Aortic Valve Endocarditismentioning

confidence: 97%

Infective Endocarditis in Aortic Valve Disease

Bustamante‐Munguira¹,

Blanco²,

Figuerola‐Tejerina³

2019

Aortic Stenosis - Current Perspectives

View full text Add to dashboard Cite

Although infective endocarditis is a rare disease, its incidence has increased over the last years and, despite improved diagnosis and treatment, it has a poor prognosis. The left side is compromised in most cases and underlying valvular heart disease is present in a substantial proportion of cases. We review the incidence, main clinical features and indications for surgery in left-sided native valve infective endocarditis, focusing on the aortic valve.

show abstract

“…IE is an uncommon disease that, as stated, carries significant morbidity and mortality and has a wide range of presentations (12) . Aortic valve IE frequency ranges between 36% to 50% (13)(14)(15) and IE of the mitral valve is observed between 34% to 42% (14)(15)(16)(17) according to several studies.…”

Section: Introductionmentioning

confidence: 94%

Surgical Aspects of Infective Endocarditis with Focus on the Aortic Root

Cuevas¹,

Savić²,

Quintana³

et al. 2018

ejcm

View full text Add to dashboard Cite

Infective endocarditis is an uncommon disease carrying a mortality between 10% and 25%. The mitral and aortic valves are involved between 34-42% and 36-50% respectively. Early and aggressive treatment is mandatory, this impacts on early and long-term outcomes. A multi-disciplinary team approach is currently accepted as standard of practice. Approximately half of the patients require cardiac surgery as a part of the treatment. In case of extravalvular spread of infection, persistent sepsis, multiple embolic events despite appropriate antibiotic therapy, acute or worsening conduction abnormalities or heart failure, urgent surgery must be considered. When the infection involves the aortic root, a radical approach is preferred. As we expected, prosthetic valve endocarditis has worst outcomes, particularly related to the higher mortality in reoperations.

show abstract

Infective endocarditis: Surgical management and prognostic predictors

Abstract: The results of this study may help to identify IE patients who are at increased risk of worse outcome, offering the opportunity to change the course of the disease and to improve prognosis with earlier and more aggressive intervention.

Cited by 26 publications

References 33 publications

Systemic immune-inflammation index predicts mortality in infective endocarditis

Systemic immune-inflammation index predicts mortality in infective endocarditis

Infective Endocarditis in Aortic Valve Disease

Surgical Aspects of Infective Endocarditis with Focus on the Aortic Root

Contact Info

Product

Resources

About