Infective endocarditis in Rio de Janeiro, Brazil: a 5-year experience at two teaching hospitals

Damasco, Paulo Vieira; Ramos, Juliana Nunes; Correal, Julio Cesar Delgado; Pötsch, Maria; Vieira, Verônica Viana; Camello, Thereza Cristina Ferreira; Pereira, Manuel P.; Marques, V. D.; Santos, Kátia Regina Netto dos; Marques, Elizabeth Andrade; Castier, Márcia Bueno; Hirata, Raphael; Mattos‐Guaraldi, Ana Luíza; Fortes, Cláudio Querido

doi:10.1007/s15010-014-0640-2

Cited by 25 publications

(48 citation statements)

References 24 publications

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“…Staphylococcus accounts for 15-50% of cases with Staphylococcus aureus more common than coagulase negative Staphylococcus (CoNS). [19][20][21][22][23]25,31,32,34 Comparison with pre-millennial ranges shows an increase in Staphylococcus which was previously reported in less than 20% of cases. 11,13,28 The emergence of Staphylococcus as a leading cause of IE in LMICs, a trend that was also previously noted in HICs, may reflect medical technology advances, increased hospital contact and increasing comorbidities.…”

Section: Staphylococcusmentioning

confidence: 59%

“…11,13,28 The emergence of Staphylococcus as a leading cause of IE in LMICs, a trend that was also previously noted in HICs, may reflect medical technology advances, increased hospital contact and increasing comorbidities. 9,34,35 Consistent with these factors, it is noteworthy that only UMIC studies reported Staphylococcus as the leading cause of IE, accounting for up to 50% of cases. 21,22,25,31,32,34 In lower-middle income countries however, Streptococcus still predominates.…”

Section: Staphylococcusmentioning

confidence: 92%

“…9,34,35 Consistent with these factors, it is noteworthy that only UMIC studies reported Staphylococcus as the leading cause of IE, accounting for up to 50% of cases. 21,22,25,31,32,34 In lower-middle income countries however, Streptococcus still predominates. 19,20 …”

Section: Staphylococcusmentioning

confidence: 92%

“…33 Two LMIC studies reported on the site of acquisition of IE. Simsek-Yavuz et al 21 characterized 23% of IE cases as HAIE at a referral centre in Turkey, while Damasco et al 34 reported predominantly HAIE (56%) in two centres in Brazil. In the latter study, an indwelling intravenous catheter was the main source of infection in the entire patient cohort, while among HAIE cases, 55% had chronic renal insufficiency as a comorbidity.…”

Section: Place Of Infection Acquisitionmentioning

confidence: 99%

“…[19][20][21][22][23]25,31,32,34 Streptococcus is common among younger patients, patients with community-acquired IE and patients with rheumatic or congenital NVE. 19,20,34 This finding was highlighted by Simsek-Yavuz et al 21 in a study in Turkey where although Staphylococcus was the leading cause of IE in the entire cohort, Streptococcus was significantly more prevalent among patients with a native valve, patients less than 40 years of age, and patients with community-acquired IE.…”

Section: Streptococcusmentioning

confidence: 99%

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Infective Endocarditis in Low- and Middle-Income Countries

et al. 2017

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Key Points Staphylococcus is an increasingly important cause of IE in LMICs, and is the leading cause of IE in UMICs  RHD remains the major underlying cardiac pathology of IE in LMICs, identified in almost half of reported cases  The rate of microorganism non-identification is high, reaching up to 60% of IE cases in LMICs, and hampering diagnosis and treatment  Rates of access to surgery in UMICs for complicated IE are as high as in HICs, but remain dismal in lower-middle income countries SynopsisInfective endocarditis (IE) is a rare, life-threatening disease with a mortality rate of upto 25% and significant debilitating morbidities. Although much has been reported on contemporary IE in high income countries, conclusions on the state of IE in low and middle income countries (LMICs) are based on studies conducted before the year 2000. Furthermore, unique challenges in the diagnosis and management of IE persist in LMICs. This article is a review of IE studies conducted in LMICs documenting clinical experiences from the year 2000 to present. We present the causes of IE, management of patients with IE and the prevailing challenges in diagnosis and treatment of IE in LMICs.

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Section: Staphylococcusmentioning

confidence: 59%

Section: Staphylococcusmentioning

confidence: 92%

Section: Staphylococcusmentioning

confidence: 92%

Section: Place Of Infection Acquisitionmentioning

confidence: 99%

Section: Streptococcusmentioning

confidence: 99%

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Infective Endocarditis in Low- and Middle-Income Countries

et al. 2017

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Antibiotic Resistance inEnterococcusspp. Friend or Foe?

Εconomou

Sakkas

Delis

et al. 2016

Foodborne Pathogens and Antibiotic Resistance

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The Changing Epidemiology of Infective Endocarditis in the Twenty-First Century

Ambrosioni

Hernández‐Meneses

Téllez

et al. 2017

Curr Infect Dis Rep

160

129

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In high-income countries, the proportion of IE related to prior rheumatic disease has decreased significantly and has been replaced proportionally by cases related to degenerative valvulopathies, prosthetic valves, and cardiovascular implantable electronic devices. Nosocomial and non-nosocomial-acquired cases have risen, as has the proportion caused by staphylococci, and the median age of patients. In low-income countries, in contrast, rheumatic disease remains the main risk factor, and streptococci the most frequent causative agents. Studies performed to evaluate impact of guidelines changes' have shown contradictory results. The increased complexity of cases in high-income countries has led to the creation of IE teams, involving several specialties. New imaging and microbiological techniques may increase sensitivity for diagnosis and detection of IE cases. In low-income countries, IE remained related to classic risk factors. The consequences of prophylaxis guidelines changes are still undetermined.

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Infective endocarditis in Rio de Janeiro, Brazil: a 5-year experience at two teaching hospitals

Cited by 25 publications

References 24 publications

Infective Endocarditis in Low- and Middle-Income Countries

Infective Endocarditis in Low- and Middle-Income Countries

Antibiotic Resistance inEnterococcusspp. Friend or Foe?

The Changing Epidemiology of Infective Endocarditis in the Twenty-First Century

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