Infective Endocarditis Due to Staphylococcus aureus: 59 Prospectively Identified Cases with Follow‐up

Fowler, Vance G.; Sanders, Linda; Kong, Li; McClelland, R. Scott; Gottlieb, Geoffrey S.; Li, Jennifer; Ryan, Thomas J.; Sexton, Daniel J.; Roussakis, Georges; Harrell, Lizzie J.; Corey, G. Ralph

doi:10.1086/515076

Cited by 176 publications

(93 citation statements)

References 37 publications

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“…Both endocarditis and osteomyelitis were also found more frequently among patients with USA300 infections than among those with USA100 infections. With the exception of intravenous drug users, patients who develop endocarditis often have health care risk factors, such as indwelling lines, history of surgery, or underlying disease, such as diabetes (12). Recent reports suggest that CA-MRSA infectious endocarditis cases could be increasing (11,25), and more than 30% of the CA-MRSA patients described in that report had recent or concurrent skin infections.…”

Section: Discussionmentioning

confidence: 97%

Characterization of Methicillin-Resistant Staphylococcus aureus Isolates Collected in 2005 and 2006 from Patients with Invasive Disease: a Population-Based Analysis

et al. 2009

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This study characterizes 1,984 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected in 2005and 2006 from normally sterile sites in patients with invasive MRSA infection. These isolates represent a convenience sample of all invasive MRSA cases reported as part of the Active Bacterial Core surveillance system in eight states in the United States. The majority of isolates were from blood (83.8%), joints (4.1%), and bone (4.2%). Isolates were characterized by pulsed-field gel electrophoresis (PFGE); SCCmec typing; susceptibility to 15 antimicrobial agents; and PCR analysis of staphylococcal enterotoxin A (SEA) to SEH, toxic shock syndrome toxin 1, and Panton-Valentine leukocidin. Thirteen established PFGE types were recognized among these isolates, although USA100 and USA300 predominated, accounting for 53.2% and 31.4% of the isolates, respectively. As expected, isolates from hospital onset cases were predominantly USA100, whereas those from community-associated cases were predominantly USA300.

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Section: Discussionmentioning

confidence: 97%

Characterization of Methicillin-Resistant Staphylococcus aureus Isolates Collected in 2005 and 2006 from Patients with Invasive Disease: a Population-Based Analysis

et al. 2009

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“…It is apparent from population-based studies in industrialized regions (127)(128)(129)142) and the prospective cohort studies from the ICE-PCS cohort (125,132,133,143,144) that the prevalence of health care-associated IE, particularly due to S. aureus, has increased. For example, Benito and colleagues reported that over one-third (34%) of a large cohort of 1,622 non-IDU patients with native valve IE had health care-associated infections (133).…”

Section: Epidemiologymentioning

confidence: 99%

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

et al. 2015

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SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

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“…In a survey, 30 % of IE was associated with healthcare settings with MRSA or Enterococcus infection, than factors like age, hyperglycemia, renal impairment and heart failure [67]. Approximately, 10 % of nosocomial bacteremia cases reportedly result in IE [82], accounts for 20 % of IE cases [83] and has a higher mortality rate in critically ill patients [83,84]. Homograft valves and pulmonary autografts are less prone to recurrent bacterial endocarditis than xenograft or mechanical valves [85].…”

Section: Infective Endocarditis (Ie)mentioning

confidence: 99%

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

2017

JCCR

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The circulating microbiome or the blood microbiome has been analysed recently in chronic inflammatory diseases like obesity, diabetes, cirrhosis and cardiovascular diseases (CVDs) in humans. Evidences that microbial components in blood could play a crucial role in the pathophysiological events leading to or during the course of disease continue to mount. The blood microbiome has been investigated primarily by profiling the circulating bacterial and viral elements using high-throughput sequencing technologies. However, the clinical implications of circulating microbiome in humans remain largely unexplored. The evidence for the presence of a stable blood microbiome in CVDs is still questionable. Nevertheless, there is evidence for a link between the circulating microbiome in obesity, diabetes and CVDs, indicating the influence of physiological, biochemical and environmental factors on the circulating microbiome in metabolic diseases. With this background, we explore the reports on the clinical consequences of bacteremia in CVD patients which formed the basis for the analyses on the topic "circulating microbiome".

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Infective Endocarditis Due to Staphylococcus aureus: 59 Prospectively Identified Cases with Follow‐up

Cited by 176 publications

References 37 publications

Characterization of Methicillin-Resistant Staphylococcus aureus Isolates Collected in 2005 and 2006 from Patients with Invasive Disease: a Population-Based Analysis

Characterization of Methicillin-Resistant Staphylococcus aureus Isolates Collected in 2005 and 2006 from Patients with Invasive Disease: a Population-Based Analysis

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

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