Infective endocarditis due to Burkholderia cepacia in a neonate: a case report

Yonas, Emir; Damay, Vito; Pranata, Raymond; Nusarintowati, Nuvi

doi:10.1186/s13256-018-1633-z

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…After two-week antibiotic treatment, the vegetations on the pulmonary valve were cleared, RV-PA connection was achieved with conduit insertion, and the Rastelli procedure was performed. To date, B. cepacia has been reported as an IE agent only in one newborn [ 44 ] .…”

Section: Discussionmentioning

confidence: 99%

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

Yakut

Ecevit

Tokel

et al. 2021

Braz J Cardiovasc Surg

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Introduction We aimed to present the risk factors, clinical and laboratory findings, treatment management, and risk factors for morbidity and mortality of infective endocarditis (IE) as well as to relate experiences at our center. Method We retrospectively analyzed data of 47 episodes in 45 patients diagnosed with definite/possible IE according to the modified Duke criteria between May 2000 and March 2018. Results The mean age of all patients at the time of diagnosis was 7.6±4.7 years (range: 2.4 months to 16 years). The most common symptoms and findings were fever (89.3%), leukocytosis (80.8%), splenomegaly (70.2%), and a new heart murmur or changing of pre-existing murmur (68%). Streptococcus viridans (19.1%), Staphylococcus aureus (14.8%), and coagulase-negative Staphylococci (10.6%) were the most commonly isolated agents. IE-related complications developed in 27.6% of the patients and the mortality rate was 14.8%. Conclusion We found that congenital heart disease remains a significant risk factor for IE. The highest risk groups included operated patients who had conduits in the pulmonary position and unoperated patients with a large ventricular septal defect. Surgical intervention was required in most of the patients. Mortality rate was high, especially in patients infected with S. aureus , although the time between the onset of the first symptom and diagnosis was short. Patients with fever and a high risk of IE should be carefully examined for IE, and evaluation in favor of IE until proven otherwise will be more accurate. In high-risk patients with prolonged fever, IE should be considered in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

Yakut

Ecevit

Tokel

et al. 2021

Braz J Cardiovasc Surg

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“…The commonly involved bacteria in developing countries include Klebsiella species, Staphylococcus aureus, E. coli, and Group B Streptococcus [8,9]. Recently, B. cepacia, a bacterial pathogen that has intrinsic drug resistance and ability to live inside drug products [10,11], has emerged as a significant pathogen causing neonatal sepsis [12][13][14][15][16].…”

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confidence: 99%

Neonatal sepsis in Sana’a city, Yemen: a predominance of Burkholderia cepacia

et al. 2021

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Background Neonatal sepsis is a global concern with increasing morbidity and mortality. The burden of neonatal sepsis is highest in developing countries, especially in those lacking proper surveillance systems. The causative pathogens and their drug-resistance levels vary between countries with emergence of multidrug resistance organisms. Thus, accurate records on the recent trends of organisms causing neonatal sepsis will provide vital information for appropriate intervention. We aimed to investigate neonatal sepsis, identify its associated factors and causative pathogens and to assess the antibiotic susceptibility patterns in Sana’a city, Yemen. Methods A cross-sectional study was conducted on neonates admitted to intensive care units of six hospitals in Sana’a city, Yemen, in the period from January 15, to March 30, 2020. Natal and prenatal medical data were collected using well-structured questionnaire. Neonates were subjected to sepsis work-up including blood culture, complete blood count and C-reactive protein. Organisms were identified by Gram staining and analyzed by the VITEK II system for bacterial bio-typing and antibiotic susceptibility testing. Findings Of the 199-neonates with suspected neonatal sepsis, 154 (77.38%) had culture-proven sepsis. Early-onset neonatal sepsis (EOS) was higher (50.25%; 100/199) than late-onset neonatal sepsis (LOS) (27.13%; 54/199). Multivariable analysis identified vaginal delivery as an independent risk factor for neonatal sepsis p = 0.005. Majority of isolated bacteria (74.39%) were gram-negative with Burkholderia cepacia (39%) and Klebsiella oxytoca (13%) being the most common pathogens of EOS and LOS. The most common gram-positive pathogens were Staphylococcus haemolyticus (9.1%) and Staphylococcus epidermidis (7.1%). B. cepacia showed multidrug resistance except for cefepime. All Klebsiella species isolates (100%) and most Pantoea species (93%) were ESBL and carbapenemase positive. All Escherichia coli and Acinetobacter baumannii isolates were ESBL positive. A significant number of gram-positive bacteria showed resistance to vancomycin. Conclusion The study findings show a high proportion of neonatal sepsis among neonates admitted to hospitals in Sana’a city with antibiotic-resistant B. cepacia being the single most common pathogen causing EOS and LOS. Findings also emphasize the emerging threat of multidrug-resistant bacteria in neonatal units and will help develop evidence-based management of neonatal sepsis in Yemen.

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“…A case of endocarditis due to B. cepacia has also been reported in a neonate. [6] B. cepacia, the emerging pathogen, is overlooked in many cases due to the low index of suspicion and awareness among microbiologists and clinicians. Therefore, due consideration should be given to this organism to know the true magnitude of its infection in our country.…”

Section: Discussionmentioning

confidence: 99%

Burkholderia Septicemia: A Case Report

Sarwat¹,

Khan²,

Dutta³

2021

JMSH

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Burkholderia cepacia is a bacterial pathogen which usually causes infection in immunocompromised or hospitalized patients. It also causes associated infections in patients with underlying pulmonary diseases, such as cystic fibrosis and chronic granulomatous diseases. It is often resistant to multiple antibiotics and has been found to grow even in medium containing penicillin. Here, we report a case of B. cepacia bacteremia in a post-operative patient of rheumatic heart disease with bilateral pleural effusion who, on being timely diagnosed, was managed effectively with appropriate antibiotics.

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Infective endocarditis due to Burkholderia cepacia in a neonate: a case report

Cited by 10 publications

References 27 publications

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

Neonatal sepsis in Sana’a city, Yemen: a predominance of Burkholderia cepacia

Burkholderia Septicemia: A Case Report

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