Infective endocarditis at autopsy in Northern India. A study of 120 cases.

Clinicomicrobiological profile of infective endocarditis in a tertiary care center of Nepal

“…Majority of patients in IE group, 72.3% (n=8) in our study were below 36 years, this is similar to all previous studies of IE from India. 4,7 But this is in contrast to the western studies where majority of patients had presented beyond the fourth decade. 9,10 This can be due to the fact that RHD continues to be a significant problem in developing world which usually presents at younger age.…”

“…The reported studies of IE from developing countries are very less. 4,7 An overall increase in the age of affected patients has been a notable feature of IE in last 30 years 8 possible reasons for this trend are the decline in incidence of rheumatic fever in the developed world, increasing numbers of adults rendered susceptible to IE by degenerative heart disease associated with old age and prolonged survival of patients with valvular disease due to improved medical and surgical treatment. Majority of patients in IE group, 72.3% (n=8) in our study were below 36 years, this is similar to all previous studies of IE from India.…”

“…This is in accordance to previous studies in developing world, which have reported culture positivity in 21-47% episodes. 4,7,26 Prior antibiotic therapy may be the important reason for high culture negativity in our series, since a high proportion of culture negative IE patients had received antibiotic therapy before admission to our hospital [36.4% (n=4)]. S. aureus have been reported as etiological agents in 13-49% of cases of native valve endocarditis.…”

Characteristics of infective endocarditis in a developing country-clinical profile and outcome in 192 Indian patients, 1992–2001

“…These changes are attributable to changes in substrate population, introduction of more accurate diagnostic criteria (Duke criteria), better diagnostic facilities, availability of a range of antibiotics and aggressive surgical approach. Published reports regarding IE are rather scanty from this part of the world [8][9][10][11][12][13] and there is no large series from any centre involved in active and aggressive cardiac interventions and surgery. Given the scenario of changing trends and scanty data, an insight into the clinical expression and a comparison with western data is warranted.…”

Cerebrovascular disease in north-west India: a study of necropsy material.

“…'9 This is another group which contributes to the higher number of stroke in the young and related to the higher incidence of RHD and infective endocarditis in this geographic area. 20 Absence …”