SummaryTwo hundred and thirty-three patients with renal amyloidosis were studied in an attempt to identify the incidence and pattern of the disease in northern India. The incidence of amyloidosis was 1 01% of 6431 postmortems and 8-4 % of 1980 renal biopsies from patients who presented with clinical evidence of glomerular disease. Two hundred and three patients (87 1 %) had secondary amyloidosis, 22 (9-4 %) had primary amyloid and 8 patients (3 5 %) had amyloidosis associated with multiple myeloma. Tuberculosis of various organs was the commonest predisposing disease accounting for 59 1% of secondary amyloidosis, followed by chronic suppurative lung disease in 241 %. Rheumatoid arthritis, chronic osteomyelitis and lepromatous leprosy were seen in a small percentage of patients (2 to 8 %). Proteinuria of varying degree was present in all the 233 patients and 12-9 % of them had a daily protein excretion of more than 10 g.Post-mortem examination of 65 patients with renal amyloidosis showed that 75-3 % also had amyloid deposit in the spleen, 63 % in the liver, and 50 8 % in the adrenals.
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