Infectious Mononucleosis Simulating Hodgkin’s Disease: A Patient with Reed-Sternberg Cells

Agliozzo, Carl M.; Reingold, Irving M.

doi:10.1093/ajcp/56.6.730

Cited by 10 publications

(4 citation statements)

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“…The findings in lymph nodes from individuals with infectious mononucleosis have been described previously (Sprunt and Evans 1920;Longcope 1922;Baldridge, Rohner, and Hansmann 1926;Downey and Stasney 1936;Gall and Stout 1940;Custer and Smith 1948;Harri-son 1966;McMahon, Gordon, and Rosen 1970;Agliozzo and Reingold 1971;Salvador, Harrison, and Kyle 1971;Tindle, Parker, and Lukes 1972;. The process in other tissues also has been described, including in tonsil (Fox 1927;Custer and Smith 1948;Lukes 1970;Tindle, Parker, and Lukes 1972), in spleen (Smith and Custer 1946;, in bone marrow (Campbell 1948;Custer and Smith 1948;Boyd and Reid 1968), in liver Hoagland and McClusky 1955;Reichman, Burke, and Davis 1957;, in central nervous system (Vaughn, Regan, and Terplan 1946;Custer and Smith 1948;Ambler et al 1971), and in various tissues in autopsy reviews and case reports (Zeigler 1944;Ainley 1949;.…”

Section: Pathology Of Infectious Mononucleosissupporting

confidence: 73%

“…Traditionally, Reed-Sternberg cells have been considered the diagnostic insignia of Hodgkin's disease (Sternberg 1898;Reed 1902;Jackson and Parker 1944;Rappaport 1966;Lukes, Butler, and Hicks 1966). It has become apparent, however, that Reed-Sternberg cells, while diagnostic for Hodgkin's disease, are not pathognomonic for that lesion and may be observed in other diseases (Harrison 1966;Symmers 1968;Lukes, Tindle, and Parker 1969;Hartsock 1968;Strum, Park, and Rappaport 1970;McMahon, Gordon, and Rosen 1970;Agliozzo and Reingold 1971;Tindle, Parker, and Lukes 1972). Infectious mononucleosis as a reactive, and therefore essentially reversible, process has been confused with Hodgkin's disease, as described by the authors cited above, as well as with other lesions in which there is marked cellular pleomorphism, including non-Hodgkin's lymphoma, especially immunoblastic sarcoma (Tindle 1981), and nonlymphoid neoplasms (Strum, Park, and Rappaport 1970).…”

Section: Pathology Of Infectious Mononucleosismentioning

confidence: 99%

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Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

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Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

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Section: Pathology Of Infectious Mononucleosissupporting

confidence: 73%

Section: Pathology Of Infectious Mononucleosismentioning

confidence: 99%

Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

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“…The SR cell is regarded as the neoplastic component of the histological lesion, although cells of similar morphology have been noted in a variety of non malignant disorders, such as infectious mononucleosis (Lukes et al, 1969;Strum et al, 1970;Tindle et al, 1972;Agliozzo & Reingold, 1971) hydantoin induced lymphadenopathy (Saltzstein et al, 1958(Saltzstein et al, , 1959 and post vaccinial lymphadenitis (Hartsock, 1968).…”

mentioning

confidence: 99%

Characteristics of Sternberg-Reed, and related cells in Hodgkin's disease: An immunohistological study

Dorreen¹,

Habeshaw²,

Stansfeld³

et al. 1984

Br J Cancer

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“…Still, although the presence of these 'Hodgkin cells' is considered a prerequisite for the diagnosis, the most characteristic of these cells, the Reed-Sternberg cells, are not specific for Hodgkin's disease. Thus, Reed-Sternberg cells have been described in such disorders as mononucleosis (Lukes et a1 1969, Strum et a1 1970, Agliozzo & Reingold 1971, rubeola, thymoma, carcinoma and various haematological malignancies (Strum et a1 1970).…”

mentioning

confidence: 99%