Infectious Mononucleosis

Dunnet, W. N.

doi:10.1136/bmj.1.5339.1187

Cited by 41 publications

(15 citation statements)

References 8 publications

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“…Our findings are similar to a prospective study by Rea et al (13), in which 31% and 61% of their patients had abnormal ALT and AST levels at their initial visits. Typically, the abnormal transaminase values are in the mildly elevated category (13,(23)(24)(25)(26)(27)(28). However, as shown in our study, these values may be moderate or more significantly elevated.…”

Section: Discussionsupporting

confidence: 43%

Correlates of Illness Severity in Infectious Mononucleosis

Odame

Khodai‐Booran

Mazzulli

et al. 2013

Paediatrics and Child Health

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INTRODUCTION:Understanding the spectrum and frequencies of Epstein-Barr virus (EBV) complications and markers of illness severity in immunocompetent patients with primary EBV infection will inform management of patients with EBV-related illnesses. OBjECTIVES: To determine the clinical and laboratory correlates of illness severity among infants, children and youth with infectious mononucleosis (IM). METHODS: Study subjects with confirmed IM were prospectively enrolled. Illness severity was assessed at baseline and at six weeks using a scoring tool. Peripheral blood viral loads served as a measure of viral burden. RESULTS: Among 32 children and young adults with IM, the median age was 16 years (range two to 24 years). 19%]). With respect to symptoms or signs that persisted to at least six weeks after illness onset, the predominant complaint was lymphadenopathy in 35% of subjects available for reassessment. Deranged liver function tests were present at presentation in up to 44% of subjects. Patients with the highest viral loads at presentation had significantly higher illness severity scores associated with fatigue (P=0.02). Other than the scores associated with fatigue, viral load values were not significantly correlated with the illness severity scores at baseline and at six weeks. CONCLUSION: In IM, viral loads are not necessarily correlated with illness severity, with the exception of fatigue. EBV-related hepatitis is common in IM, confirming the status of this virus as a relatively common cause of transient hepatitis in children and youth. This entity is not necessarily a marker of disease severity. Key Words: Epstein-Barr virus; Hepatitis; Mononucleosis; Viral loadDes corrélats de la gravité de la maladie en cas de mononucléose infectieuse

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Section: Discussionsupporting

confidence: 43%

Correlates of Illness Severity in Infectious Mononucleosis

Odame

Khodai‐Booran

Mazzulli

et al. 2013

Paediatrics and Child Health

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show abstract

“…Pulmonary involvement during acute infectious mononucleosis is rare (Dunnet, 1963). EpsteinBarr virus-infected lymphocytes can infiltrate the lung, especially in AIDS patients, and this condition is characterized pathologically by interstitial pneumonitis with marked mononuclear inflammatory infiltrate (Sriskandan et al, 1996).…”

Section: Epstein-barr Virusmentioning

confidence: 99%

The Pathology of Community-Acquired Pneumonia

Molina

Walker

2002

Community-Acquired Pneumonia

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“…These disadvantages also apply to isocitrate dehydrogenase (Watts, 1966;Goldberg et al, 1966) despite earlier reports that its activity in serum is usually normal in hepatobiliary obstruction but almost invariably raised in parenchymal disease of the liver (Bell, Shaldon, and Baron, 1962). However, it is much more specific for liver disease than the aminotransferases and is somewhat more sensitive in detecting acute hepatic damage, especially that due to drugs (Watts and Griffiths, 1964), alcohol (Goldberg and Watts, 1965), and infectious mononucleosis (Dunnet, 1963). Serum adenosine deaminase activity was shown by the author to be raised in hepatic parenchymal disease, but is usually normal in extrahepatic obstruction (Goldberg, 1965;Goldberg et al, 1966).…”

Section: Other Enzymesmentioning

confidence: 99%

Enzymes in the Diagnosis of Myocardial Infarction and Liver Disease

Goldberg¹

1971

Ann Clin Biochem

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Infectious Mononucleosis

Cited by 41 publications

References 8 publications

Correlates of Illness Severity in Infectious Mononucleosis

Correlates of Illness Severity in Infectious Mononucleosis

The Pathology of Community-Acquired Pneumonia

Enzymes in the Diagnosis of Myocardial Infarction and Liver Disease

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