Enzymes in the Diagnosis of Myocardial Infarction and Liver Disease

Goldberg, David M.

doi:10.1177/000456327100800167

Cited by 8 publications

(2 citation statements)

References 52 publications

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“…Alanine transaminase is a useful index of liver damage (Goldberg, 1971) but as ALT is also found in cardiac tissue (Schmidt and Schmidt, 1967), though proportionally much less than is AST, it is unwise to use increases in serum ALT activity alone as an index of liver damage following myo-cardial infarction. It has also been shown in this study that ALT, a useful index of liver damage, is more often increased in patients with increased GMT activity and favours the argument that increases in serum GMT activity following myocardial infarction are a result of secondary liver damage.…”

Section: Discussionmentioning

confidence: 99%

Serum D-glutamyl transferase following myocardial infarction

Connell

1973

J Clin Pathol

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SYNoPSIS D-glutamyl transferase (GMT) activity was measured in 49 patients with proven myocardial infarction. Twenty-three patients had normal GMT activity and 26 had increased GMT activity. Most of the patients with increased GMT had evidence of liver dysfunction and it is suggested that any increases in serum GMT activity following myocardial infarction are a result of secondary liver damage rather than a release of GMT from cardiac tissue.

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Section: Discussionmentioning

confidence: 99%

Serum D-glutamyl transferase following myocardial infarction

Connell

1973

J Clin Pathol

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“…in this clinical setting include GOT [17], CPK [3], LDH [28], and HBD [25], All are sufficiently lacking in specificity as to render determination of all three as a diagnostic profile highly desirable [8,9,27].…”

Section: Introductionmentioning

confidence: 99%

Serum Enolase and Pyruvate Kinase Activities in the Diagnosis of Myocardial Infarction

Herraez-Dominguez¹,

Goldberg²,

Anderson³

et al. 1976

Enzyme

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Sequential determinations of serum enolase and pyruvate kinase (PK) activities were carried out in addition to routine enzyme assays on 191 patients admitted to a coronary care unit. The upper reference values established in 61 healthy laboratory staff members were 21 U/l for enolase and 76 U/l for PK. Of 99 patients with a confirmed diagnosis of myocardial infarction (MI), 97 manifested raised serum enolase during the period of observation; 85 of these patients had raised serum PK. The incidence of raised values for serum PK among patients considered not to have sustained infarction was similar to that shown by the routine enzymes, but serum enolase activity was much more frequently raised in these patients. The time-course of elevation of serum enolase and also that of PK are discussed in relation to the changes in other serum enzymes routinely measured for MI.

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