Serum D-glutamyl transferase following myocardial infarction

Connell, Margaret D.

doi:10.1136/jcp.26.9.684

Cited by 6 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that the increased y-GT activity in myocardial infarction is caused by subclinical hepatic hypoxia (Betro et al, 1973;Connell, 1973) although others have proposed that tissue repair processes in the myocardium explain such increases (Ewen and Griffiths, 1971;Szczeklik et al, 1972). Ravens et al (1969) found very little y-GT in normal dog heart, but it increased after experimental coronary artery ligation.…”

Section: Group 4 Reflected Normal Sera In Their Responsementioning

confidence: 96%

Butanol Extraction of Serum and Urinary Gamma-Glutamyltransferase and its Application in Clinical Diagnosis

Beck

1978

Ann Clin Biochem

View full text Add to dashboard Cite

Summary Gamma-glutamyltransferase (γ-GT) activity was measured in serum and urine before and after extraction with n-butanol. Residual γ-GT activity after extraction of normal serum with butanol was more than 75 %, whereas for normal urine the figure was less than 68 %. The loss of activity from urine was not affected by prior dialysis, and the stabilisation which resulted from adding bovine serum albumin at a concentration of 40 g/l did not approach the residual activity with normal serum. In patients with a variety of renal diseases, residual γ-GT activity in the urine after butanol extraction was inversely correlated with the creatinine clearance. Butanol extraction was performed on serum samples from 182 patients with a variety of diseases. Eighty-one per cent of patients with elevated γ-GT activities caused by hepatobiliary disease had an increased loss of activity after butanol extraction. By contrast, only 34 % of patients with increased γ-GT activities in whom there was no clinical or other biochemical evidence of hepatic disease, had increased loss of γ-GT activity after butanol. The reasons for differences between urinary and serum γ-GT in response to butanol, and the implications in interpreting serum γ-GT activities are discussed.

show abstract