Infectious human papillomavirus virions in semen reduce clinical pregnancy rates in women undergoing intrauterine insemination

Depuydt, Christophe; Donders, Gilbert Ghislain Gerard; Verstraete, Ludo; Broeck, Davy Vanden; Beert, Johan; Salembier, Geert; Bosmans, Eugène; Ombelet, Willem

doi:10.1016/j.fertnstert.2019.02.002

Cited by 45 publications

(48 citation statements)

References 44 publications

(47 reference statements)

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“…Second, many demographic variables were not available in the database, such as body mass index, tobacco or alcohol consumption status, lifestyle factors, socioeconomic status, family medical history, fertility status, infertile male partners, and the possibility of being influenced by HPV-infected fertile male partners. Lyu et al showed that the overall prevalence of HPV DNA in semen was higher in fertility clinic attendees than in the general population [27], and Depuydt et al found that couples undergoing intrauterine insemination had a significant decrease in clinical pregnancy rate when infectious HPV virions were detected in the sperm [40]. These factors contribute to the development of infertility, and these confounders are an inherent limit of the NHIRD.…”

Section: Discussionmentioning

confidence: 99%

Female Human Papillomavirus Infection Associated with Increased Risk of Infertility: A Nationwide Population-Based Cohort Study

Hsu

Tsui

Wei

et al. 2020

IJERPH

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Objective. This study investigated whether women with a history of human papillomavirus (HPV) infection have an increased risk of infertility. Material and Methods. All patients with an HPV infection (n = 11,198) in Taiwan’s National Health Insurance Research Database (2000–2012) were propensity score matched with control subjects (n = 11,198) without an HPV infection by age, sex, index year, and relevant co-morbidities. Both groups were tracked until a diagnosis of infertility was recorded. The Chi-square test was used to analyze the distribution of demographic characteristics in the HPV group and non-HPV group. A Cox proportional hazards regression was used to estimate the hazard ratios (HRs) for the development of infertility, adjusting for age, sex, and co-morbidities. The Kaplan–Meier method was used to plot the cumulative incidence curves. We also performed negative controls to test for possible unmeasured confounding. Results. The HPV cohort had a higher risk of infertility. The adjusted HR (aHR) was found to be 1.39 (95% CI = 1.19–1.63) after adjusting for demographic characteristics and relevant co-morbidities. In the age subgroup analysis, patients with an HPV infection had an increased risk of infertility compared to the non-HPV cohort in the group aged 26 to 35 years (aHR, 1.53; 95% CI = 1.24–1.88). As we used propensity score matching to treat measurable confounders and negative controls to access unmeasured confounders, the findings of the study are robust. Conclusions. Among females of reproductive age, HPV infection is a potential risk factor that predisposes individuals to subsequent infertility.

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Section: Discussionmentioning

confidence: 99%

Female Human Papillomavirus Infection Associated with Increased Risk of Infertility: A Nationwide Population-Based Cohort Study

Hsu

Tsui

Wei

et al. 2020

IJERPH

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“…And also, infected sperm is able to penetrate the oocyte, to deliver HPV genome in the oocyte and to increase the risk of pregnancy loss [2]. In vivo study, cumulative pregnancy rates after IUI and ICSI treatments showed significantly lower in HPV infected couples compared with non-infected couples, and also miscarriage rates were higher in HPV infected couples [4][5][6]. Hermonat et al [12] reported that spontaneous miscarriage products were more prevalent (60%) for HPV-DNA sequences compared to elective aborted products (20%).…”

Section: Discussionmentioning

confidence: 99%

“…Infected spermatozoa could be a vector for HPV transmission into fertilized oocytes and the infected zygote is able to perpetuate the viral genome expression at blastocyst stage and subsehttp://www.e-kmj.org Keimyung Med J quently in trophoblastic cells [3]. When semen was infected with HPV in the cycle of intrauterine insemination (IUI) or in vitro fertilization (IVF), clinical pregnancy rate was decreased [4,5]. Moreover, an increased risk of pregnancy loss and preterm delivery was reported in HPV infected male partners [4,6].…”

Section: Introductionmentioning

confidence: 99%

Influence of Human PapillomaVirus Infection Detected by Cervical Swap on In-vitro Fertilization Outcomes

Kim

Park

2020

Keimyung Med J

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Human papilloma virus (HPV) infection had been suspected of harmful effect on reproduction by increasing blastocyst apoptosis and reducing the endometrial implantation of trophoblastic cells. However, the available evidence is conflicting concerning the impact of HPV in female reproductive system on the outcome of in-vitro fertilization (IVF) The aim of study was to evaluate IVF outcomes regarding the cervical HPV infection. Retrospective case-control study conducted in women suffered IVF cycle. All women were evaluated the HPV infection using PCR by cervical swap before the initiation of IVF cycle. One hundred thirty six cycles were evaluated. The harvested oocytes number, top quality embryo number, fertilization rate, implantation rate, clinical pregnancy rate, live birth rate and miscarriage rate were analyzed depend on HPV infection. Mean age of enrolled women was 35.20±4.79 years-old, mean parity was 0.17±0.57, and mean number of miscarriage was 0.81±1.49. Basal FSH was 5.42±2.59 IU/L and AMH level was 5.07±11.01 ng/ mL, which was not different between two groups. Mean harvested oocytes was 6.36±4.32 in HPV infected women compared with 8.63±5.95 in women without infection, statistically insignificant. Top quality embryos of each group were not different (2.67±0.82, 2.53±1.53 separately). In women with HPV infection, ongoing pregnancy rate (27.3%) and live birth rate (18.2%) were similar with women without infection (23.7%, 14.0%). And also, fertilization rate and implantation rate were similar. Miscarriage rate of each group was 33.3%, and 40.7%, which was statistically insignificant. The HPV infection in women did not make the adverse influence on IVF outcomes.

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“…Recent reports have described a statistically significant negative effect of human papilloma virus (HPV) positivity in men and women on clinical pregnancy rates after IUI (9,10). Therefore, HPV-positive women and men should not receive IUI as a first-line treatment although it is unknown yet whether HPV positivity has an effect on IVF-ICSI pregnancy rates.…”

Section: Pro (Ivf): Couples With Unexplained Infertility Should Be Rementioning

confidence: 99%

Should couples with unexplained infertility have three to six cycles of intrauterine insemination with ovarian stimulation or in vitro fertilization as first-line treatment?

Ombelet

Eekelen

McNally

et al. 2020

Fertility and Sterility

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Infectious human papillomavirus virions in semen reduce clinical pregnancy rates in women undergoing intrauterine insemination

Cited by 45 publications

References 44 publications

Female Human Papillomavirus Infection Associated with Increased Risk of Infertility: A Nationwide Population-Based Cohort Study

Female Human Papillomavirus Infection Associated with Increased Risk of Infertility: A Nationwide Population-Based Cohort Study

Influence of Human PapillomaVirus Infection Detected by Cervical Swap on In-vitro Fertilization Outcomes

Should couples with unexplained infertility have three to six cycles of intrauterine insemination with ovarian stimulation or in vitro fertilization as first-line treatment?

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