Infections broncho-pulmonaires à Staphylococcus aureus

Valour, Florent; Chebib, Nader; Gillet, Yves; Reix, Philippe; Laurent, François; Chidiac, Christian; Ferry, Tristan

doi:10.1016/j.pneumo.2013.08.004

Cited by 13 publications

(12 citation statements)

References 95 publications

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“…CT scan showed a necrotizing pattern, with multiple confluent abscesses, almost bilateral, with interstitial infiltrate and pleural effusion [ 4 ]. Pediatric forms were more often associated to pneumothorax and pneumatocele [ 7 ]. Many features of S .…”

Section: Discussionmentioning

confidence: 99%

“…aureus did not carry PVL gene or exhibited other particular virulence factors we did not searched for [ 15 ]. Unfortunately, we have not realized genotypic identification of particular virulence factors such as the clonal complex, alpha-type phenol-soluble modulins, arginine catabolic mobile element, and mostly alpha-hemolysin [ 2 , 7 , 15 ]. Because of the retrospective design of this study, only routinely tested virulence factors were available.…”

Section: Discussionmentioning

confidence: 99%

“…In these circumstances of necrotizing community-acquired pneumonia (NCAP), microbiological investigation may reveal a particular virulence of S . aureus related to carriage and expression of the Panton-Valentine Leukocidin (PVL) gene [ 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia

et al. 2017

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ObjectWe observed some cases of lung abscess (LA) in ICU patients suffering S.aureus ventilator-associated pneumonia (S.aureus-VAP). We aimed to assess which of the host and/or bacteria-related features are associated with LA.MethodsWe conducted a retrospective study from January 2009 to July 2013 in a trauma surgical ICU within a teaching hospital. All adult patients presenting with S.aureus-VAP were included. We compared two groups of patients according to the formation or not of LA concomitantly to S.aureus-VAP.ResultsSeventy-nine S.aureus-VAP patients, predominantly males (85%) of rather young age (mean [SD]: 35yr [21–64]) with severe trauma (initial Simplified Acute Score II = 42 [32–52]) related-ICU admission, were included. Among them, 10 (14%) developed LA. Patient’s characteristics significantly associated with LA development were: a younger age (p = 0.003), road traffic accidents admission (p = 0.017), head injury (p = 0.002), lower Glasgow Coma Scale (p = 0.009), blunt chest trauma (p = 0.01) pneumothorax (p = 0.01) and lung contusions (p = 0.002). No microbiological factors were significantly associated with LA formation. Abscesses were mostly bilateral, ≥5 cm of diameter and with a posterior location.ConclusionsOur results do not favor a specific virulence of S.aureus, but rather highlight the role of multiple insults to the lung, promoting LA formation. Despite a similar severity score, patients with LA had more serious trauma, combining severe both chest and head insults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia

et al. 2017

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“…In this study, even more remarkable was the growing antibiotic resistance of staphylococci to penicillin and ß-lactamase inhibitor antibiotics. Staphylococci are generally sensitive to ß-lactam antibiotics [ 82 ]; however, a large proportion of staphylococcal strains are developing antibiotic resistance to penicillin [ 83 ]. This antibiotic resistance is based on the formation of penicillinases [ 84 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period

2015

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BackgroundStaphylococci can cause wound infections and community- and nosocomial-acquired pneumonia, among a range of illnesses. Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) have been rapidly increasing as a cause of infections worldwide in recent decades. Numerous reports indicate that S. aureus and MRSA are becoming resistant to many antibiotics, which makes them very dangerous. Therefore, this study retrospectively investigated the resistance to antimicrobial agents in all hospitalized patients suffering from community- or nosocomial-acquired pneumonia due to S. aureus and MRSA.MethodsInformation from the study groups suffering from either community- or nosocomial-acquired pneumonia caused by S. aureus or MRSA was gathered by searching records from 2004 to 2014 at the HELIOS Clinic Wuppertal, Witten/Herdecke University, Germany. The findings of antibiotic resistance were analyzed after the evaluation of susceptibility testing for S. aureus and MRSA.ResultsTotal of 147 patients (63.9%, 95% CI 57.5%–69.8%), mean age 67.9 ± 18.5 years, with pneumonia triggered by S. aureus, and 83 patients (36.1%, 95% CI 30.2%–42.5%), mean age 72.3 ± 13.8 years, with pneumonia due to MRSA. S. aureus and MRSA developed no resistance to vancomycin (P = 0.019 vs. < 0.0001, respectively) or linezolid (P = 0.342 vs. < 0.0001, respectively). MRSA (95.3%) and S. aureus (56.3%) showed a high resistance to penicillin. MRSA (87.7%) was also found to have a high antibiotic resistance against ß-lactam antibiotics, compared to S. aureus (9.6%). Furthermore, MRSA compared to S. aureus, respectively, had increased antibiotic resistance to ciprofloxacin (90.1% vs. 17.0%), cefazolin (89.7% vs. 10.2%), cefuroxime (89.0% vs. 9.1%), levofloxacin (88.2% vs. 18.4%), clindamycin (78.0% vs. 14.7%), and erythromycin (76.5% vs. 20.8%).ConclusionNo development of resistance was found to vancomycin and linezolid in patients with pneumonia caused by S. aureus and MRSA.

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“…Staphylococcus aureus causes different types of infections, ranging from simple infections in skin and soft tissues to more serious diseases such as infective endocarditis, sepsis and pneumonia. 6, 7 The spread of methicillin-resistant S. aureus (MRSA) is on escalation and presents a major threat.…”

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confidence: 99%

Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part

Megahed

Rasheed

Herrmann

et al. 2022

Bioorganic & Medicinal Chemistry Letters

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Infections broncho-pulmonaires à Staphylococcus aureus

Cited by 13 publications

References 95 publications

The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia

The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia

No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period

Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part

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