Infections à méningocoques

Nicolas, Pierre; Debonne, Jean-Marc

doi:10.1016/s1166-8598(02)00077-7

Cited by 6 publications

(4 citation statements)

References 115 publications

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“…Meningococcal disease epidemics are due to the expansion of one single clone (Achtman 1995; Nicolas & Debonne 2002). In the 2000 survey in Ghana, Gagneux et al.…”

Section: Discussionmentioning

confidence: 99%

Outbreaks of serogroup X meningococcal meningitis in Niger 1995–2000

Djibo

Nicolas

Alonso

et al. 2003

Tropical Med Int Health

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SummaryIn the African meningitis belt, the recurrent meningococcal meningitis epidemics are generally caused by serogroup A. In the past 20 years, other serogroups have been detected, such as X or W135, which have caused sporadic cases or clusters. We report here 134 meningitis cases caused by Neisseria meningitidis serogroup X that occurred in Niamey between 1995 and 2000. They represented 3.91% of the meningococcal isolates from all CSF samples, whereas 94.4% were of serogroup A. Meningococcal meningitis cases were detected using the framework of the routine surveillance system for reportable diseases organized by the Ministry of Public Health of Niger. The strains were isolated and determined by the reference laboratory for meningitis in Niamey (CERMES) and further typed at the WHO collaborating center of the Pharo in Marseille and at the National Reference Center for the Meningococci at the Institut Pasteur. Reference laboratories in Marseille and Paris characterized 47 isolates having the antigenic formula (serogroup:serotype:sero-subtype) X:NT:P1.5. Meningitis cases due to meningococcus serogroup X did not present any clinical or epidemiological differences to those due to serogroup A. The seasonal incidence was classical; 93.3% of the cases were recorded during the dry season. The mean age of patients was 9.2 years (±6 years). The sex ratio M/F was 1.3. Case fatality rate was 11.9% without any difference related to age or sex. The increasing incidence of the serogroup X was not related to the decrease of serogroup A, but seemed cyclic, and evolved independently of the recurrence of both serogroups A and C.

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“…Meningococcal disease epidemics are due to the expansion of one single clone (Achtman 1995; Nicolas & Debonne 2002). In the 2000 survey in Ghana, Gagneux et al.…”

Section: Discussionmentioning

confidence: 99%

Outbreaks of serogroup X meningococcal meningitis in Niger 1995–2000

Djibo

Nicolas

Alonso

et al. 2003

Tropical Med Int Health

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“…Meningococcus is a Gram-negative diplococcus found only in human respiratory secretions. It creates microthrombotic processes depriving the more distal and less oxygenated tissues from sufficient blood supply, and also deprivation in coagulation factors, leading to shock and multiple-organ damage [1,2]. Orthopedic consequences may arise if histological structures linked to growth are concerned, except that the early diagnosis of these sequelae is often difficult.…”

Section: Introductionmentioning

confidence: 99%

Meningococcal purpura fulminans in children. II: Late orthopedic sequelae management

Nectoux

Mezel

Raux

et al. 2010

Journal of Children's Orthopaedics

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It is important for children diagnosed with meningococcal purpura fulminans to be followed up closely starting from the very beginning by a pediatric orthopedic surgeon. It ensures that late-onset orthopedic sequelae will be diagnosed early. In accordance to the literature, this study highlights the high rate of lower limb epiphysiodesis, above all other types of sequelae. This study reports a possible link between purpura fulminans and avascular necrosis of the hip.

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“…This purpura fulminans condition can seldom also be caused by other Gram-negative bacteria and by hemorrhagic fever viruses or varicella zoster virus (VZV). In France, purpura fulminans accounts for one-fifth of all meningococcal infections, which represents about 1.03 cases per million inhabitants [3].…”

Section: Introductionmentioning

confidence: 99%

Meningococcal purpura fulminans in children: I. Initial orthopedic management

Nectoux

Mezel

Raux

et al. 2010

Journal of Children's Orthopaedics

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Background Purpura fulminans is a rare and extremely severe infection, mostly due to Neisseria meningitidis frequently causing early orthopedic lesions. Few studies have reported on the initial surgical management of acute purpura fulminans. The aim of this study is to look at the predictive factors in orthopedic outcome in light of the initial surgical management in children surviving initial resuscitation. Methods Nineteen patients referred to our institution between 1987 and 2005 were taken care of at the very beginning of the purpura fulminans. All cases were retrospectively reviewed so as to collect information on the total skin necrosis, vascular insufficiency, gangrene, and total duration of vasopressive treatment.

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Infections à méningocoques

Cited by 6 publications

References 115 publications

Outbreaks of serogroup X meningococcal meningitis in Niger 1995–2000

Outbreaks of serogroup X meningococcal meningitis in Niger 1995–2000

Meningococcal purpura fulminans in children. II: Late orthopedic sequelae management

Meningococcal purpura fulminans in children: I. Initial orthopedic management

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