Infection with virulent strains of Helicobacter pylori is not associated with ischaemic heart disease: evidence from a population-based case-control study of myocardial infarction

Murray, Liam; Bamford, K. B.; Kee, Frank; McMaster, Dorothy; Cambien, François; Dallongeville, Jean; Evans, Alun

doi:10.1016/s0021-9150(99)00325-1

Cited by 40 publications

(21 citation statements)

References 20 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been shown that these strains induce a stronger inflammatory response (48)(49) and are strongly associated with IHO (50). However, in agreement with previous findings (18,51), the results of the present study show that virulent strains are equally prevalent in both controls and cases, suggesting that infection with CagA-positive strains of H. pylori does not represent a major risk factor for IHO. Recently, Aceti et al (52), evaluating the possible role of H. pylori infection in acute IHO, suggested that virulent strains other than CagAstrains may be involved.…”

Section: Discussionsupporting

confidence: 93%

Serum and Mucosal Cytokine Profiles in Patients with Active Helicobacter Pylori and Ischemic Heart Disease: Is There a Relationship?

Bonaventura

Piccolomini

Pompilio

et al. 2007

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

This study is designed to investigate, for the first time, circulating and gastric mucosal levels ofILl-a, IL-6, IL-8 and TNF-a in patients with ischemic heart disease (IUD) and matched controls, according to the presence or absence of active Helicobacter pylori infection. Furthermore, in order to evaluate whether modified lipid profile was associated to an increased cardiovascular risk, this was determined in the same groups. Cytokine levels were measured using ELISA in 58 patients with IUD and 52 controls. Active H. pylori infection was assessed if either culture of H. pylori or rapid urease test gave a positive result. Our findings indicate increasing cytokine mucosal levels in H. pylori-positive patients compared to H. pylorinegative subjects. However, the increase was statistically significant only for IL-6 and TNF-a in the gastric mucosa of IUD patients. In H. pylori-positive controls, IL-8 mucosal levels positively correlated with both IL-la (r = 0.98; P = 0.0003) and IL-6 (r = 0.83; P = 0.03) levels. Circulating cytokine levels were comparable in IUD and healthy subjects, regardless of H. pylori status. There were no correlations between mucosal and circulating cytokine levels. Active H. pylori infection was not associated with a modified lipid profile in either controls or IUD patients, although ApoAI levels were significantly higher in H. pylori-positive controls compared to those H. pylori-negative. Taken together, the results of the present study provide evidence that active H. pylori infection may playa role as a trigger factor in the pathophysiology of IUD by inducing an inflammatory cascade concentrated on gastric mucosa. Cardiovascular diseases constitute one of the leading causes for mortality and morbidity in industrialized countries (I). In particular, ischemic heart disease (IHD) is the single biggest contributor to cardiac mortality. Major factors associated with an increased risk of IHD are well known, but not all of IHD incidence can be attributed to serum lipids, hypertension, smoking, obesity and diabetes (2). It is, therefore, important to identify additional causes ofIHD.Atherosclerosis is now generally accepted as an inflammatory disorder in the arterial wall (3). Since the first evidence reported by Mendall et al. (4), a number of studies have confirmed the key

show abstract

Section: Discussionsupporting

confidence: 93%

Serum and Mucosal Cytokine Profiles in Patients with Active Helicobacter Pylori and Ischemic Heart Disease: Is There a Relationship?

Bonaventura

Piccolomini

Pompilio

et al. 2007

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

show abstract

“…The most recently published study14 compared 259 cases of myocardial infarction with the same number of population based controls and, after adjustments, reported an odds ratio of 1.16 (95% CI 0.79 to 1.70).…”

Section: Discussionmentioning

confidence: 99%

Ischaemic heart disease and Cag A strains of Helicobacter pylori in the Caerphilly heart disease study

Stone

2001

Heart

View full text Add to dashboard Cite

Objective-To look for the presence of the more virulent strains of Helicobacter pylori (H pylori) in men who developed ischaemic heart disease over a 10 year period and in controls. Design-The Caerphilly prospective heart disease study recruited 2512 men aged 45-59 years during 1979-83. Western blot analysis or enzyme linked immunosorbent assay (ELISA) was performed on serum taken from those who subsequently died of ischaemic heart disease, or developed non-fatal myocardial infarction, to determine H pylori and Cag A status. Similar information was available on age matched controls. Results-During the first decade of the study, 312 men died of ischaemic heart disease or developed non-fatal myocardial infarction. Serum was available from 172 of these (55%). There was no evidence of an association between Cag A seropositivity and incident ischaemic heart disease or ischaemic heart disease mortality, either before or after adjustment for potential confounders (adjusted odds ratios 1.18 (95% confidence interval (CI) 0.76 to 1.85) and 1.13 (95% CI 0.61 to 2.07), respectively). Further, the odds ratios for ischaemic heart disease incidence and ischaemic heart disease mortality by H pylori seropositivity did not appear to depend on the presence or absence of Cag A strains (p = 0.76 and 0.77, respectively). Conclusions-In this cohort of middle aged men, followed over a 10 year period, there is little evidence of an association between Cag A seropositivity and either incident ischaemic heart disease or ischaemic heart disease mortality. (Heart 2001;86:506-509)

show abstract

“…11 Although subsequent reports 26 -31 did not uniformly confirm this finding, even negative studies 26,27,30 showed a significant or near-significant difference in the crude prevalence of CagA-positive strains between patients and control subjects, which was attenuated after adjustment for covariates. However the OR remained Ͼ1 in all cases.…”

Section: Our Data In the Context Of Available Literaturementioning

confidence: 94%

Cytotoxin-Associated Gene-A–Positive Helicobacter pylori Strains Are Associated With Atherosclerotic Stroke

et al. 2002

View full text Add to dashboard Cite

Background-It is uncertain whether Helicobacter pylori is associated with ischemic syndromes and whether this association is mediated by the induction of atherosclerosis. In this study, we tested the hypothesis that atherosclerotic stroke shows a selective association with virulent H pylori strains. Methods and Results-The seroprevalence of infection by H pylori and by strains bearing the cytotoxin-associated gene-A (CagA), a strong virulence factor, was assessed by ELISA in 138 patients with large-vessel stroke (group A), in 61 patients with cardioembolic stroke (group B), and in 151 healthy control subjects. The 3 groups had a similar socioeconomic status. Serum levels of C-reactive protein were also measured by ELISA.

show abstract

Infection with virulent strains of Helicobacter pylori is not associated with ischaemic heart disease: evidence from a population-based case-control study of myocardial infarction

Cited by 40 publications

References 20 publications

Serum and Mucosal Cytokine Profiles in Patients with Active Helicobacter Pylori and Ischemic Heart Disease: Is There a Relationship?

Serum and Mucosal Cytokine Profiles in Patients with Active Helicobacter Pylori and Ischemic Heart Disease: Is There a Relationship?

Ischaemic heart disease and Cag A strains of Helicobacter pylori in the Caerphilly heart disease study

Cytotoxin-Associated Gene-A–Positive Helicobacter pylori Strains Are Associated With Atherosclerotic Stroke

Contact Info

Product

Resources

About