Infection with<i>Mycobacterium tuberculosis</i>Beijing Genotype Strains Is Associated with Polymorphisms in<i>SLC11A1/NRAMP1</i>in Indonesian Patients with Tuberculosis

Crevel, Reinout van; Parwati, Ida; Sahiratmadja, Edhyana; Marzuki, Sangkot; Ottenhoff, Tom H. M.; Netea, Mihai G.; Ven, André van der; Nelwan, R.H.H.; Meer, J W van der; Alisjahbana, Bachti; Vosse, Esther van de

doi:10.1086/648477

Cited by 78 publications

(67 citation statements)

References 15 publications

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“…PGL which has been identified in other Euro-American strains, has been linked to hypervirulence phenotypes in laboratory studies that used macrophages and animal models (Coscolla and Gagneux, 2010;Malik and Godfrey-Faussett, 2005). Furthermore, East Asian isolates have been associated with more severe cavitary disease (Cowley et al, 2008;Parwati et al, 2010;van Crevel et al, 2009). Combined, our data provide evidence to demonstrate that 'modern' lineages particularly East Asian and Euro-America strains evolved non-lethal but aggressive/destructive properties in the lungs which enhanced intergenerational propagation.…”

Section: Discussionsupporting

confidence: 54%

“…Previous studies have described host, pathogen, environmental, and lifestyle factors associated with outcomes after TB exposure, after latent Mycobacterium tuberculosis infection, or after TB disease (Blaser and Kirschner, 2007;Caws et al, 2008;Coscolla and Gagneux, 2010;Kato-Maeda et al, 2001;Malik and Godfrey-Faussett, 2005;Pasipanodya et al, 2012b;van Crevel et al, 2009). Clinical studies have not demonstrated clear relationships between host genetic susceptibility factors, M. tuberculosis lineages, and TB outcomes (Caws et al, 2008;van Crevel et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

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Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Pasipanodya

Moonan

Vecino

et al. 2013

Infection, Genetics and Evolution

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Background-Host pathogen relationships can be classified as allopatric, when the pathogens originated from separate, non-overlapping geographic areas from the host; or sympatric, when host and pathogen shared a common ancestral geographic location. It remains unclear if hostpathogen relationships, as defined by phylogenetic lineage, influence clinical outcome. We sought to examine the association between allopatric and sympatric phylogenetic Mycobacterium tuberculosis lineages and pulmonary impairment after tuberculosis (PIAT).

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Pasipanodya

Moonan

Vecino

et al. 2013

Infection, Genetics and Evolution

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“…A study of Vietnamese subjects detected an association between the C allele of TLR2 597T/C and TB caused by East Asian/Beijing genotype M. tuberculosis strains (41). Genetic variations in the 3=-UTR and the D543N SNP of SLC11A1 (NRAMP1) were significantly associated with susceptibility to infection by M. tuberculosis Beijing strains in Indonesian TB patients (241) and with the incidence of MDR-TB cases in Japan (223), which suggests an influence of bacterial genotype/ phenotype on host innate immunity. To what extent these same variants also interact with other M. tuberculosis strains remains to be tested.…”

Section: Factors That Influence the Functions Of Innate Immune Gene Pmentioning

confidence: 99%

Innate Immune Gene Polymorphisms in Tuberculosis

2012

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ABSTRACTTuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single infectious agent. Recent studies targeting candidate genes and “case-control” association have revealed numerous polymorphisms implicated in host susceptibility to TB. Here, we review current progress in the understanding of causative polymorphisms in host innate immune genes associated with TB pathogenesis. We discuss genes encoding several types of proteins: macrophage receptors, such as the mannose receptor (MR, CD206), dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN, CD209), Dectin-1, Toll-like receptors (TLRs), complement receptor 3 (CR3, CD11b/CD18), nucleotide oligomerization domain 1 (NOD1) and NOD2, CD14, P2X7, and the vitamin D nuclear receptor (VDR); soluble C-type lectins, such as surfactant protein-A (SP-A), SP-D, and mannose-binding lectin (MBL); phagocyte cytokines, such as tumor necrosis factor (TNF), interleukin-1β (IL-1β), IL-6, IL-10, IL-12, and IL-18; chemokines, such as IL-8, monocyte chemoattractant protein 1 (MCP-1), RANTES, and CXCL10; and other important innate immune molecules, such as inducible nitric oxide synthase (iNOS) and solute carrier protein 11A1 (SLC11A1). Polymorphisms in these genes have been variably associated with susceptibility to TB among different populations. This apparent variability is probably accounted for by evolutionary selection pressure as a result of long-term host-pathogen interactions in certain regions or populations and, in part, by lack of proper study design and limited knowledge of molecular and functional effects of the implicated genetic variants. Finally, we discuss genomic technologies that hold promise for resolving questions regarding the evolutionary paths of the human genome, functional effects of polymorphisms, and corollary impacts of adaptation on human health, ultimately leading to novel approaches to controlling TB.

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“…A single gene that is not associated with susceptibility to TB will show an association if combined with other genes [38,39]. Besides, gene-agent interaction showed association of a certain host gene with a certain strain of Mycobacterium tuberculosis [40,41].…”

Section: Discussionmentioning

confidence: 99%

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis?

Siregar¹,

Sinaga²

2017

JHS

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Abstract:The active metabolite of vitamin D activates macrophages and results in the restriction of growth of Tuberculosis (TB) pathogen M. tuberculosis. The effect of vitamin D is achieved through binding to the Vitamin D Receptor (VDR), which ultimately produces the antimicrobial peptide Cathelicidin. Matched case-control study with 76 pulmonary tuberculosis Indonesian Batak ethnic patients and 76 healthy normal control were completed. Genetic polymorphisms of VDR gene were analysed using PCR and RFLP. The genotype frequencies of ApaI were AA 10.6%, Aa 44.7%, aa 44.7% for the control group and AA 10.6%, Aa 43.4%, aa 46% for the PTB patients. For the FokI genotype the frequencies were FF 39.5%, Ff 44.7%, ff 15.8% for the control group and FF 35.5%, Ff 55.3%, ff 9.2% for the PTB patients. In these two genotypes there were no significant differences found between the control group and the PTB patients (P > 0.05). Besides, there genotypic frequencies were in agreement with the Hardy-Weinberg Equilibrum (P > 0.05). However, for the BsmI genotype frequencies, BB 2.6%, Bb 23.7% and bb 73.7% for the control group and BB 0%, Bb 68.4%, bb 31.6% for the PTB patients, there was a significant association found with PTB; the bb genotype is correlated with a decreased risk for PTB (OR 0.22, 95% CI: 0.11-0.45). ApaI and FokI polymorphisms of VDR gene do not appear to be responsible for host susceptibility to pulmonary tuberculosis in the Indonesian Batak ethnic population but BsmI polymorphism had association with host resistant to PTB.

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Infection withMycobacterium tuberculosisBeijing Genotype Strains Is Associated with Polymorphisms inSLC11A1/NRAMP1in Indonesian Patients with Tuberculosis

Cited by 78 publications

References 15 publications

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Innate Immune Gene Polymorphisms in Tuberculosis

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis?

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