Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs

Calistri, Paolo; Amato, Laura; Puglia, Ilaria; Cito, Francesca; Giuseppe, Alessandra Di; Danzetta, Maria Luisa; Morelli, Daniela; Domenico, Marco Di; Caporale, Marco; Scialabba, Silvia; Portanti, Ottavio; Curini, Valentina; Perletta, Fabrizia; Cammà, Cesare; Ancora, Massimo; Savini, Giovanni; Migliorati, Giacomo; D’Alterio, Nicola; Lorusso, Alessio

doi:10.1016/j.ijid.2021.03.005

Cited by 89 publications

(89 citation statements)

References 6 publications

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“…Analysing a cohort of 341 patients, including 198 (58%) with B.1.1.7 infections, the authors correlated outcomes with granular clinical data. Their observation that B.1.1.7 infections were associated with increased viral loads corroborates findings from two other studies 4,5 and provides a mechanistic hypothesis that increased transmissibility is via increased respiratory shedding. Yet, disease severity and clinical outcomes between patients with B.1.1.7 and non-B.1.1.7 infections were similar after adjusting for differences in age, sex, ethnicity, and comorbidities.…”

supporting

confidence: 85%

Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

Ong

Young

Lye

2021

The Lancet Infectious Diseases

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supporting

confidence: 85%

Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

Ong

Young

Lye

2021

The Lancet Infectious Diseases

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“…However, the limited sequence data available as well as the lack of metadata makes it challenging to accurately identify the directionality of transmission and lineage spread across the country, although our previous study similarly showed limited interregional transmission during the lockdown period [ 16 ]. Although no metadata regarding virulence was available for the sequence data included here, it was recently shown that some B.1.1.7 variants are characterized by longer persistence and higher viral RNA loads in nasopharyngeal swabs [ 26 ], in the UK the B.1.1.7 is associated with both a higher production number and a greater hazard of death [ 5 ]. Of note, no clade defining amino acid substitutions were found for the B.1.1.7 lineage in spike gene of Italian sequences analyzed here.…”

Section: Discussionmentioning

confidence: 99%

Emergence and Spread of SARS-CoV-2 Lineages B.1.1.7 and P.1 in Italy

Giallonardo

Puglia

Curini

et al. 2021

Viruses

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Italy’s second wave of SARS-CoV-2 has hit hard, with more than three million cases and over 100,000 deaths, representing an almost ten-fold increase in the numbers reported by August 2020. Herein, we present an analysis of 6515 SARS-CoV-2 sequences sampled in Italy between 29 January 2020 and 1 March 2021 and show how different lineages emerged multiple times independently despite lockdown restrictions. Virus lineage B.1.177 became the dominant variant in November 2020, when cases peaked at 40,000 a day, but since January 2021 this is being replaced by the B.1.1.7 ‘variant of concern’. In addition, we report a sudden increase in another documented variant of concern—lineage P.1—from December 2020 onwards, most likely caused by a single introduction into Italy. We again highlight how international importations drive the emergence of new lineages and that genome sequencing should remain a top priority for ongoing surveillance in Italy.

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“…Transmissibility/viral load and duration : This VOC is reportedly 43-82% more transmissible[ 25 ], with conflicting data suggesting elevated viral loads that persist longer[ 26 ], or no significant differences in viral load(VL)[ 27 ]. Notably, implementation of strict public health and social measures successfully reduced transmission.…”

Section: Characteristics Of Who Designated Vocsmentioning

confidence: 99%

Novel SARS-CoV-2 variants: the pandemics within the pandemic

Boehm

Kronig

Neher

et al. 2021

Clinical Microbiology and Infection

307

216

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Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs

Cited by 89 publications

References 6 publications

Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

Emergence and Spread of SARS-CoV-2 Lineages B.1.1.7 and P.1 in Italy

Novel SARS-CoV-2 variants: the pandemics within the pandemic

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