Infection spontanée et expérimentale de la marmotte alpine (Marmota marmota) par le virus de l'hépatite de la marmotte nord-Américaine (Marmota monax) premiers résultats

Chomel, Bruno B; Trépo, C; Pichoud, C; Jacquet, Christine; Boulay, P.; Joubert, Louis

doi:10.1016/0147-9571(84)90024-9

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…The present study con®rms the susceptibility of M. monax, and describes for the ®rst time that M. marmota, the Alpine woodchuck, also presents a similar susceptibility. Unfortunately, M. marmota is not susceptible to the WHV [18]. Both species exhibited a similar and very peculiar behavior when infected with S. mansoni, the infection presenting a biphasic course.…”

Section: Discussionmentioning

confidence: 99%

“…Four eastern woodchucks (M. monax) and three alpine woodchucks (Marmota marmota, [18]), males and females, with weights varying from 6.4 to 2.4 kg, were submitted to infection by subcutaneous injection of approximately 500 recently eliminated S. mansoni cercariae of a Brazilian strain [19]. Some animals received a second inoculum 1 or 2 months following the ®rst infection, the total number of cercariae reaching 650± 1350.…”

Section: Single Infection With S Mansonimentioning

confidence: 99%

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Schistosomiasis mansoni and viral B hepatitis in woodchucks

Andrade

Berthillon

Paraná

et al. 2001

Journal of Hepatology

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Schistosomiasis and viral hepatitis in woodchucks run parallel courses, with neither apparent special histological features derived from the association of the two conditions, nor modulation of WHV replication. Schistosomiasis itself, however, was observed to run a peculiar course in the woodchuck. The present data are important for consideration in further experiments exploring the interplay between schistosomiasis and viral hepatitis induced liver damage in this unique experimental host.

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Section: Discussionmentioning

confidence: 99%

Section: Single Infection With S Mansonimentioning

confidence: 99%

Schistosomiasis mansoni and viral B hepatitis in woodchucks

Andrade

Berthillon

Paraná

et al. 2001

Journal of Hepatology

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“…whereas in the State of New York and New England, in general, carriers are not observed. The European marmot (Marmota marmota) does not seem to be susceptible to WHV [8],…”

Section: Introductionmentioning

confidence: 99%

The Woodchuck: An Animal Model for Hepatitis B Virus Infection in Man

1995

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Since the discovery of woodchuck hepatitis virus (WHV) in 1978, the virus and its host, the American woodchuck, have been studied and used as the most suitable model for human hepatitis B virus infection. WHV is closely related to the human virus, having strong similarities in morphology, genome structure and gene products, replication, epidemiology, the course of infection and in the development of illness and hepatocellular carcinoma. Because of this high homology, the woodchuck model is used for many studies for the development of new vaccines, therapeutic vaccination and antiviral agents. In addition, the woodchuck system is used for investigation of molecular mechanisms of the viral life cycle, the mechanisms of carcinogenesis and cell infection.

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“…Although there is no risk of confusing the viral particles of VHD or EBHS with those of hepatitis B (since hépadnavirus has characteristic polymorphism, with small particles measuring 22 nm, large Dane's particles of 42 nm and filaments of 100 nm), it is interesting to recall that the hépadnavirus group includes viruses capable of inducing hepatitis in ducks (duck hepatitis virus) and in species phylogenetically close to Leporidae: the American marmot (woodchuck hepadnavirus) and squirrel (ground squirrel and tree squirrel hepadnaviruses) (1,4,20).…”

Section: Dna Virusmentioning

confidence: 99%

Hépatites d'origine virale des léporidés : introduction et hypothèses étiologiques

Morisse¹,

Gall²,

Boilletot³

1991

Rev. Sci. Tech. OIE

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In less than ten years, two very serious viral hepatic diseases have spread through Leporidae populations (rabbits and hares) in numerous countries. In May 1989, the Office International des Epizooties designated this new disease of rabbits "viral haemorrhagic disease" and entered it as a List B disease in the International Animal Health Code. Clinically, the disease is very similar to the European brown hare syndrome. However, numerous uncertainties prevail today on the true nature of the viruses of the two species. Although they are related, the viruses appear to be different and cross infection between species has given contradictory results. Hepatitis of Leporidae have probably existed in Europe for several years, although their viral aetiology has been demonstrated only recently. The acute form has occurred in hares in Northern Europe since approximately 1980, while the inapparent (or ignored) form has been present in rabbits in Czechoslovakia since 1975. These diseases of Leporidae are true viral hepatitis which, in their fulminating forms, bear a remarkable resemblance to human viral hepatitis (B and non-A non-B) with regard to clinical symptoms, pathological lesions and mode of transmission. The dominant faecal-oral transmission observed for types A and E hepatitis would explain the particular susceptibility of family-kept rabbits, as they are fed potentially contaminated fodder. As the clinically similar fulminating hepatitis in human beings is caused by a diversity of viruses (both RNA and DNA), the disease in Leporidae might also be caused by different viruses. Although there has been no report of human infection from an animal source, sufficient similarities exist between Leporidae and human viral hepatitis to encourage joint research in the specialised medical fields.

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Infection spontanée et expérimentale de la marmotte alpine (Marmota marmota) par le virus de l'hépatite de la marmotte nord-Américaine (Marmota monax) premiers résultats

Cited by 8 publications

References 8 publications

Schistosomiasis mansoni and viral B hepatitis in woodchucks

Schistosomiasis mansoni and viral B hepatitis in woodchucks

The Woodchuck: An Animal Model for Hepatitis B Virus Infection in Man

Hépatites d'origine virale des léporidés : introduction et hypothèses étiologiques

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