Schistosomiasis mansoni and viral B hepatitis in woodchucks

Andrade, Zilton de Araújo; Berthillon, Pascale; Paraná, Raymundo; Ja, Grimaud; Trépo, C.

doi:10.1016/s0168-8278(00)00068-4

Cited by 6 publications

(10 citation statements)

References 21 publications

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“…Patients presenting the hepatosplenic form of schistosomiasis associated with hepatitis B usually show persistent viremia and exhibit chronic active hepatitis on liver biopsy, sometimes with the clinical picture of so-called decompensated schistosomiais, evolving to cirrhosis. Similar findings were also observed with viral hepatitis C (see review in Andrade et al 2001). However, some studies denied any special relationship between schistosomiasis and infections with hepatotropic viruses.…”

Section: The Significance Of Chronic Hepatitissupporting

confidence: 62%

Schistosomal hepatopathy

Andrade

2004

Mem. Inst. Oswaldo Cruz

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Advanced schistosomiasis produces in man one of the most characteristic gross picture presentation of hepatic pathology. On the cut surface of the liver this lesion appears as whitish fibrous plaques replacing portal spaces on a background of normal looking hepatic parenchyma (Fig. 1C, D). Exactly one century ago, Symmers (1904) classically described this picture after performing autopsies in Egypt. It represents the anatomical counterpart of the clinical condition known as hepatosplenic schistosomiasis. A cursory gross and microscopic examination of the lesion will reveal important clues about its pathogenesis. It can then be noted that the lesion resulted from the deposition of numerous schistosome eggs along the periportal tissues, which provoked chronic granulomatous inflammation with consequent fibrous expansion of the portal spaces and intrahepatic portal vein obstruction. The parenchyma usually maintains its normal architecture, in a good correlation with the preservation of the normal hepatic function, as usually exhibited by the patients. The presence of numerous eggs points to the pathogenetic importance of worm load. Thus, schistosomal hepatopathy seems a good example of a straightforward condition, with a simple, characteristic, and understandable pathology.Although these main lines mentioned above are correct, they say little about the complexities that this unique type of chronic hepatopathy discloses when more closely and properly investigated. A closer view of its physiopathology will reveal several points of interests that are usually overlooked, but that are important for the understanding of the disease in patients and so are worth discussing here. Schistosomal hepatopathy represents a special type of a chronic liver disease. Its pathology contains unique features, one of the most important refers to its vascular changes, which differs from those found in cirrhosis, and are key factors for the understanding of the fundamental pathogenesis and the clinical potential for evolution presented by hepatosplenic schistosomiasis.

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Section: The Significance Of Chronic Hepatitissupporting

confidence: 62%

Schistosomal hepatopathy

Andrade

2004

Mem. Inst. Oswaldo Cruz

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“…Woodchuck hepatitis B infection was apparently not affected by S. mansoni infection (Andrade et al 2001). Surprisingly hepatitis B replication in HBV transgenic mice was inhibited by S. mansoni infection (McClary et al 2000).…”

Section: Interaction Of Schistosomiasis With Other Diseasesmentioning

confidence: 90%

“…It has long been clear that T helper cells (CD4+ T cells) are instrumental for the formation of granulomas around S. mansoni eggs (Mathew & Boros 1986) and that CD8+ (Anderson et al 1991, Andrade et al 2001; 2: Calomys callosus ; 3: Mastomys coucha (Cheever 1965a, b); 4: (Phillips et al 1987); 5: (Denoya et al 1997, Cêtre et al 1999; 6: Mesocricetus auratus (Cheever 1965a, b;7: Pachyuromys duprasi natronensis (Cheever 1965a, b;8: Sciurus carolinensis (Lichtenberg et al 1962) T cells appear to be important for downregulation of granuloma size in chronic infections (Chensue & Boros 1979, Henderson et al 1992), but antibody is necessary in addition to downregulated T cells ).…”

Section: The Formation Of Circumoval Granulomas and Modulation Of Gramentioning

confidence: 99%

“…Heavily infected animals of several species may develop colonic ulcerations and bloody diarrhea but it is unclear whether these bear any relation to lesions or symptoms and signs in humans. Infected woodchucks have only slight hepatic fibrosis but marked fibrosis of the intestine (Andrade et al 2001).…”

Section: Extrahepatic Pathologymentioning

confidence: 99%

“…They cause some degree of portal fibrosis which is never disseminated or systematized. The infection runs an auto-cure course (Andrade et al 2001).…”

Section: Special Consideration Of the Rabbit And Wood-chuckmentioning

confidence: 99%

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