Infection Rates of Rifampin/Gentamicin-Coated Titan Coloplast Penile Implants. Comparison with Inhibizone-Impregnated AMS Penile Implants

Abstract

Introduction It is a common practice to soak Titan® Coloplast penile implants in antibiotic solution prior to implantation. Experience with Inhibizone impregnation suggests that rifampin coating significantly reduces infection rates of penile implant surgery. In this article we describe the results of coating Titan Coloplast penile implants with rifampin/gentamicin solution. Aim To compare infection rates of Titan® Coloplast penile implants coated with vancomycin/gentamycin, rifampin/gentamicin, and Inhibizone-impregnated American Medical Systems (AMS) penile implants. Methods Chart review was done for all Mentor/Coloplast and AMS implant surgeries performed at our center between the dates January 1, 2002 and February 8, 2010. Infection rates for Titan® Coloplast penile implants coated with vancomycin/gentamycin, rifampin/gentamicin, and Inhibizone-impregnated (AMS) penile implants were compared. Main Outcome Measures Infection rates for penile implants coated with different antibiotics. Results Infection rates for Titan® Coloplast penile implants coated with vancomycin/gentamycin and Inhibizone-impregnated (AMS) penile implants was 4.4% and 1.3%, respectively (P = 0.05). None of the rifampin/gentamicin-coated Titan® Coloplast penile implants have developed infection. Rifampin is the common antibiotic both in rifampin/gentamicin-coated Coloplast implants and Inhibizone®. The infection rate in this combined rifampin/gentamicin-coated Titan Coloplast implants and Inhibizone-coated AMS implants group was 0.63% (P = 0.03). Conclusion Both rifampin/gentamicin-coated Titan® Coloplast penile implants and Inhibizone-impregnated (AMS) penile implants appear to have lower infection rates compared with vancomycin/gentamycin-coated Titan® Coloplast penile implants The present study does not suggest superiority of rifampin/gentamicin-coated Titan® Coloplast penile implants or Inhibizone-impregnated (AMS) penile implants but we strongly suggest that all Titan® Coloplast penile implants should be coated with rifampin/gentamicin solution.

Infection Retardant Coated Inflatable Penile Prostheses Decrease the Incidence of Infection: A Systematic Review and Meta-Analysis

“…We attempted to include as many studies as possible to increase the power of the meta-analysis but certain population groups did not have enough human clinical studies to increase precision. As such, we are aware that V/G subgroup results from the study by Dhabuwala et al 23 are inconsistent with the perception that an infection retardant coating should show an overall lower infection rate. This may have been attributable to the target spectrum of the chosen antibiotic not covering the biofilm bacteria 8 or to the limited number of cases and/or fewer studies in this field.…”

“…[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] However, to our knowledge a meta-analysis has not been done to evaluate these innovations.…”

Prospective Evaluation of Patient Satisfaction, and Surgeon and Patient Trainer Assessment of the Coloplast Titan One Touch Release Three-Piece Inflatable Penile Prosthesis

“…Standardized antibiotic coating of the hydrophilic surface of the Titan device may help. Dhabuwala's group has suggested that rifampin and gentamicin may be the ideal choice of antibiotic solution [20].…”

History, Contemporary Outcomes, and Future of Penile Prostheses: A Review of the Literature

“…The solution utilized to prepare Coloplast devices with hydrophilic coatings may be associated with subsequent infection rates. Dhabuwala and colleagues reported significantly lower infection rates with Titan implants using rifampin/gentamicin (0%, N = 81) compared with vancomycin/gentamicin (4.4%, N = 181) ( P = 0.05) .…”