Infection of sheep with adult and larval Ostertagia circumcincta: gastrin

Scott, Ian; Hodgkinson, Suzanne M.; Lawton, D.E.B.; Khalaf, S; Reynolds, Gordon; Pomroy, W.E.; Simpson, H.V.

doi:10.1016/s0020-7519(98)00112-x

Cited by 14 publications

(5 citation statements)

References 40 publications

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“…189,190 Calves infected with Ostertagia ostertagi have elevated gastrin 191 while sheep infected with Ostertagia circumcincta have reduced gastrin and somatostatin þ cells and this is linked to the development of hypergastrinemia in parasitized animals. 192 Furthermore, helminth induced alterations are not limited to mammal livestock with increases in CCK cells seen in Eubothrium crassum infected trout 193 and Anisakis simplex infected flounders; 194 while CCK and gastrin þ cell increase, but GLP-1/2 reduce in Eubothrium crassum infected trout. 193 Experimental murine models have been used to further dissect the association of helminth infection with alterations in eec function.…”

Section: Infection Models and Human Correlationmentioning

confidence: 99%

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

2018

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The intestinal epithelium must balance efficient absorption of nutrients with partitioning commensals and pathogens from the bodies' largest immune system. If this crucial barrier fails, inappropriate immune responses can result in inflammatory bowel disease or chronic infection. Enteroendocrine cells represent 1% of this epithelium and have classically been studied for their detection of nutrients and release of peptide hormones to mediate digestion. Intriguingly, enteroendocrine cells are the key sensors of microbial metabolites, can release cytokines in response to pathogen associated molecules and peptide hormone receptors are expressed on numerous intestinal immune cells; thus enteroendocrine cells are uniquely equipped to be crucial and novel orchestrators of intestinal inflammation. In this review, we introduce enteroendocrine chemosensory roles, summarize studies correlating enteroendocrine perturbations with intestinal inflammation and describe the mechanistic interactions by which enteroendocrine and mucosal immune cells interact during disease; highlighting this immunoendocrine axis as a key aspect of innate immunity.

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Section: Infection Models and Human Correlationmentioning

confidence: 99%

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

2018

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“…Although epithelial hyperplasia has not been a consistent finding, trichostrongylids infecting other species, including Ostertagia ostertagia in cattle, Ostertagia circumsincta in small ruminants, Trichostrongylus axei in horses, and Nochtia nochti in Asian macaques, have been associated with proliferative gastric or abomasal lesions. 20, 22 Trichostrongylid gastritis in most species is typically characterized by similar mucous neck cell hyperplasia and by mild lymphocytic inflammation.…”

mentioning

confidence: 99%

Gastric Adenocarcinoma and Chronic Gastritis in Two Related Persian Cats

Dennis

Bennett²,

Ehrhart³

2006

Vet Pathol

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Two 12.5-year-old castrated male Persian cats from the same household, whose dams were littermates, presented simultaneously with gastric adenocarcinoma associated with proliferative and fibrosing gastritis. Intralesional adult Ollulanus tricuspis nematodes and rare surface-associated spiral-shaped bacteria were identified in one cat. No etiologic agents were identified in tissues from the second cat; however, gastric mucosa was examined following anthelmintic treatment. Clinical signs in each cat had commenced 2 months apart and included vomiting, hematemesis, intermittent melena, and weight loss. This is the first report of gastric adenocarcinoma occurring in housemate cats or cats of common descent. Carcinogenesis may have been influenced by shared undetermined genetic and environmental factors, possibly including Ollulanus tricuspis, spiral-shaped bacteria, or other etiologies for chronic gastritis that remain unidentified.

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“…increases pepsinogen release. 1,15 The hyperplastic changes in the glands are associated with chronic irritation during the development of the parasite in tissue 19 and chemicals such as host growth factor-alpha with cytotoxic / inhibitory effect for cells and released by parasites. 20…”

Section: Discussionmentioning

confidence: 99%