Gastric Adenocarcinoma and Chronic Gastritis in Two Related Persian Cats

Abstract

Two 12.5-year-old castrated male Persian cats from the same household, whose dams were littermates, presented simultaneously with gastric adenocarcinoma associated with proliferative and fibrosing gastritis. Intralesional adult Ollulanus tricuspis nematodes and rare surface-associated spiral-shaped bacteria were identified in one cat. No etiologic agents were identified in tissues from the second cat; however, gastric mucosa was examined following anthelmintic treatment. Clinical signs in each cat had commenced 2 months apart and included vomiting, hematemesis, intermittent melena, and weight loss. This is the first report of gastric adenocarcinoma occurring in housemate cats or cats of common descent. Carcinogenesis may have been influenced by shared undetermined genetic and environmental factors, possibly including Ollulanus tricuspis, spiral-shaped bacteria, or other etiologies for chronic gastritis that remain unidentified.

Gastric Neoplasia in Horses

“…Similarly, gastric adenocarcinoma is exceedingly rare in cats. 13,14 Gastric leiomyoma was much less common than gastric SCC in our study, which is consistent with previous literature. 1,2 No specific etiology for the development of gastric neoplasia has been identified in domestic animals, making it difficult to explain the variation in tumor type frequency.…”

“…However, the risk of equine gastric adenocarcinoma appears to be remarkably small despite the 1 : 1 ratio of glandular to squamous mucosa in the equine stomach. Similarly, gastric adenocarcinoma is exceedingly rare in cats 13,14 . Gastric leiomyoma was much less common than gastric SCC in our study, which is consistent with previous literature 1,2 .…”

“…Finally, the horse with mesothelioma involving the serosa of the stomach had diffuse infiltration and disseminated tumors throughout the abdomen. Similar to the overall metastatic rate found in our study, metastasis is found in 58 to 74% of small animals at the time of gastric neoplasia diagnosis 11–13 …”

“…Similar to the overall metastatic rate found in our study, metastasis is found in 58 to 74% of small animals at the time of gastric neoplasia diagnosis. [11][12][13] Treatment of most abdominal neoplasia, including gastric neoplasia, is restricted in horses because of the poor accessibility of much of the abdominal viscera, the advanced stage of disease by the time a diagnosis is reached, and financial constraints involved with extensive surgical procedures and chemotherapeutics. No horses in this study were discharged from the hospital after a diagnosis of gastric neoplasia was made.…”

<b>Contribuição do exame ultrassonográfico para o diagnóstico das neoplasias gastrintestinais em felinos</b>

“…É mais raro no estômago, com frequência de 1%; e intestino grosso (9% válvula íleocólica; 2% ceco, 13% cólon e 3% reto) (CRIBB, 1988;RIVERS et al, 1997;BEDFORD, 1998;BENNETT;EHRHART, 2006;RISSETTO et al, 2011).…”