Infection by the Retrovirus Associated With the Acquired Immunodeficiency Syndrome: Clinical, Biological, and Molecular Features

Lévy, J; Kaminsky, Lawrence S.; Morrow, W. J. W.; Steimer, Kathelyn S.; Luciw, Paul A.; Dina, Dino; Hoxie, James A.; Oshiro, Lyndon S.

doi:10.1016/s0022-5347(17)44958-5

Cited by 12 publications

(18 citation statements)

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“…Very low titres of HIV have been found in the urine of patients with AIDS but no cases of seroconversion have been reported in health workers exposed to the urine of HIV-infected patients [104,105]. In the unfortunate event of occupational exposure to HIV, after simplè ®rst-aid', the HIV specialist should be noti®ed immediately.…”

Section: Surgerymentioning

confidence: 99%

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

2001

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Section: Surgerymentioning

confidence: 99%

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

2001

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“…Although cytopathic effects on lymphoid cells are a characteristic feature of HIV infection (46)(47)(48)(49), the molecular basis for cell killing is unknown. Our results show that HIV trans-activation can lead to increases in viral mRNA levels.…”

mentioning

confidence: 99%

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

Peterlin

Luciw²,

Barr

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

281

185

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The genome of human immunodeficiency virus encodes a protein that dramatically elevates amounts of viral proteins. The precise mechanism of this trans-activation remains to be established. It has been reported that transactivation can occur without major changes in the levels of mRNA. We constructed recombinant plasmids containing those viral sequences required in cis for trans-activation linked to the chloramphenicol acetyltransferase gene. These plasmids were introduced into cultured cells in either the presence or absence ofa second plasmid that directed expression ofthe viral trans-activator protein. Expression of the chloramphenicol acetyltransferase gene was measured at the level of protein (by enzymatic assay) and RNA (by ribonuclease protection and primer extension). Our results demonstrate that trans-activation is accompanied by large increases in mRNA levels; these increases may be sufficient to explain the elevated levels of trans-activated protein.

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“…The cause of AIDS is a newly recognized human virus that appears to belong to the lentivirus subfamily of retroviruses (13). The sudden onset of this disease in the world has raised questions of its origin and the reason for its transmission.…”

Section: Discussionmentioning

confidence: 99%

“…All sera were tested at dilutions 1:5 and 1:10 for antibodies to HIV by a standard indirect immunofluorescence assay using HUT-78 cells chronically infected with HIVsF2 (formerly ARV-2) (11). The sera were also tested by an immunoblot technique (12,13). This procedure used lysates of HUT-78 cells infected with HIVsF2 in which the following viral proteins were detected: gpl60, gp120, p65, p55, p48, p41, p31, p25, and p16.…”

mentioning

confidence: 99%

Absence of antibodies to the human immunodeficiency virus in sera from Africa prior to 1975.

Levy¹,

Pan²,

Beth‐Giraldo³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

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Infection by the Retrovirus Associated With the Acquired Immunodeficiency Syndrome: Clinical, Biological, and Molecular Features

Cited by 12 publications

References 0 publications

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

The urologist and the patient infected with human immunodeficiency virus or with acquired immunodeficiency syndrome

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

Absence of antibodies to the human immunodeficiency virus in sera from Africa prior to 1975.

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