Infection and Infertility

Wu, Wei; Tang, Qiuqin; Gu, Hongchen; Chen, Yiqiu; Xia, Yankai; Sha, Jiahao; Wang, Xinru

doi:10.5772/62500

Cited by 3 publications

(4 citation statements)

References 82 publications

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“…İnfertilite çok farklı etyolojilerin rol oynadığı önemli bir toplumsal problemdir. Viral infeksiyonların infertilite etyolojisinde rolü net olmayıp, son yıllarda çoğunlukla asemptomatik seyreden viral infeksiyonların infertilite patogenezindeki idiyopatik etkisi ile ilgili çalışmalar artış göstermiş ve semen bu infeksiyonların bulaşında bir vektör olarak tanımlanmıştır [6,8] .…”

Section: Discussionunclassified

“…Virüsün sperm parametreleri üzerinde birtakım değişikliklere neden olduğu (sperm ha-reketliliği ve semen PH değişimleri, sperm DNA fragmantasyonunda artış gibi) çeşitli çalışmalarda bildirilmiştir [6] . Ancak sperm parametrelerinde hangi değişikliğin HPV ile ilişkilendirilebileceği konusunda ortak bir görüş sağlanamadığı gibi, çalışma sonuçlarının da çelişkili olduğu görülmektedir [8] . Bu uyumsuz sonuçların HPV'nin erkek üreme sisteminin hangi bölgesinde infeksiyon oluşturup persistan kaldığı ile ilişkili olabileceği ve ko-infeksiyonun infertilite için ek bir risk oluşturacağı bildirilmiştir [14] .…”

Section: Discussionunclassified

“…Semende HIV, HBV ya da HCV gibi kronik viral etkenlerin varlığının sperm parametrelerini zayıflattığı, DNA stabilitesini bozduğu, canlılık ve hareketi azalttığı bildirilmiştir [6,8] . Semen kalitesindeki bozulmaların viral yük ile paralellik gösterdiği, antiviral tedavi sonrasında sperm parametrelerinde belirgin iyileşme olduğu ve özellikle IVF kliniklerinde sperm yıkama prosedürlerindeki modifikasyonlarla virüsün bulaşının engellenebileceği belirtilmektedir [6,8] . Kadınlarda özellikle tubal ve uterin faktör infertilitesi ile ilişkilendirilen HBV infeksiyonunun embriyo gelişimini engelleyerek düşük gibi olumsuz sonuçlara yol açabildiği bildirilmektedir [24] .…”

Section: Kadınlardakiunclassified

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Prevalence of Various Sexually Transmitted Pathogens in Infertile Couples and Their Effects on In Vitro Fertilization Success

Gürsoy¹,

Tuncay²,

Karaer³

et al. 2019

FLORA

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* Bu çalışmadaki verilerin bir kısmı, uluslararası 38. Türk Mikrobiyoloji cemiyeti kongresi (4-8 kasım 2018, Antalya)'nde sözlü sunum olarak sunulmuştur. ÖZ Giriş: Cinsel yolla bulaşan infeksiyonlar kadın ve erkek genital sisteminde oluşturduğu doku hasarı ve fonksiyon kayıpları ile infertilite, ektopik gebelik ve abortus gibi sorunlara neden olabilmektedir. İnfertilite etyopatogenezinde bakteriyel ajanların rolü iyi bilinmesine karşılık, cinsel ilişki ile bulaşabilen bazı viral etkenlerin infertilite ile olan ilişkileri göreceli olarak daha az bilinmektedir. Bu çalışmada in vitro fertilizasyon (IVF) programına alınan infertil hastalarda sitomegalovirüs (CMV), insan papillomavirüs (HPV), herpes simpleks virüs (HSV 1 ve HSV 2), insan immünyetmezlik virüsü (HIV), hepatit B virüsü (HBV), hepatit C virüsü (HCV) ve Chlamydia trachomatis sıklığının araştırılması amaçlanmıştır. Materyal ve Metod: Yaklaşık bir yıllık sürede 149 infertil çiftten semen ve servikal örnekler alındı ve polimeraz zincir reaksiyonu (PCR) yöntemiyle etkenlerin varlığı araştırıldı. Bu etkenlerin IVF tedavi başarısı üzerine etkisi değerlendirildi.

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Section: Discussionunclassified

Section: Kadınlardakiunclassified

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Prevalence of Various Sexually Transmitted Pathogens in Infertile Couples and Their Effects on In Vitro Fertilization Success

Gürsoy¹,

Tuncay²,

Karaer³

et al. 2019

FLORA

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“…Previous research shows that a significant proportion of male infertility is idiopathic, and the underlying molecular mechanisms is still unknown (6). The significant factors of male infertility are low sperm concentration (oligospermia), poor sperm motility (asthenospermia), and abnormal sperm morphology (teratospermia), and other less associated male infertility factors are semen volume and seminal markers of epididymal, prostatic, and seminal vesicle function (7,8).…”

Section: Introductionmentioning

confidence: 99%

A correlative interaction between thyroid dysfunction and semen parameters in male infertility: A prospective case control study

Rao

Devi

Rajarajeswari

et al. 2022

Acta Medica Martiniana

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The role of thyroid function on sperm quality has not been well studied from a pathological aspect. This study aimed to report the degree of association between the status of thyroid hormones, sperm quality and aetiology in infertile men compared to healthy subjects. A prospective case control investigative study was conducted on 100 infertile males and age matched healthy controls. Semen samples were collected for sperm quality examination, and the serum levels of tetraiodothyronine (T4), triiodothyronine (T3), and thyroid stimulation hormone (TSH) were measured. Out of 100 infertile men, oligozoospermia (32%), asthenozoospermia (48%), and oligo-asthenozoospermia (20%) were found. There was a statistical difference between the group I and group II groups related to sperm count (28.32 ± 14.60 vs 66.50 ± 10.50 x 106/ml), sperm motility (40.1 ± 13.8 vs 64.8 ± 7.85%), and sperm morphology (55.92 ± 5.27 vs 83.50 ± 5.25%, p<0.05). There was a statistical difference among the oligozoospermia, asthenozoospermia, and oligo-asthenozoospermia groups related to T3 (115 + 0.40 vs 1.29 ± 0.59 vs 1.25 ± 0.32 ng/ml), T4 (7.35 ± 1.42 vs 9.15 ± 1.85 vs 7.85 ± 1.65 μg/dl), and TSH (1.69 ± 0.55 vs 2.12 ± 1.45 vs 1.98 ± 0.4 μIU/ml) (P<0.05). There was a significant inverse correlation of TSH levels with sperm volume (r = -0.12, p= 0.02), sperm motility (r = -0.26, p= 0.02), and sperm morphology (r = -0.304, p = 0.02) observed. T4 levels were significantly correlated with sperm count (r = -0.278, p = 0.02), and sperm motility (r = -0.249, p = 0.032). T4 levels were very highly associated with asthenozoospermia. Relative operating curve analysis shows that Sperm motility of >40.1%, T3 levels of <1.29 ng/ml, total T4 levels of <8.42 μg/dl, TSH levels of <1.98 μIU/ml inferred the male infertility. Although thyroid function screening is not currently recommended as a part of the diagnostic workup of the infertile male, it may be reconsidered in light of the physiopathological background. Studies will be necessary to initiate the trial of a small dose of anti-thyroid drug in asthenozoospermic patients.

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Non-Invasive Diagnostics of Reproductive Failure with Infectious Etiology on Menstrual Tissue

Mesechkova,

Kavrakova,

Georgieva

et al. 2023

Acta Medica Bulgarica

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Aim: We investigated the role of bacterial (Chlamydia trachomatis, Ureaplasma urealyticum/ parvum, Mycoplasma hominis/genitalium, Gardnerella vaginalis) and viral (HSV1/2, EBV, CMV, VZV, HHV6/HHV7, HHV8) pathogens, as a potential cause of reproductive failure in women by testing menstrual tissue samples. Materials and methods: We examined DNA extracted from 180 probands selected on the basis of their infertility background. DNA extraction, real-time qPCR, agarose gel-electrophoresis were applied. Results: In 61,1% of all tested menstrual tissue samples of infertile women bacterial and/ or viral pathogens were detected. In 48,8% of all tested samples we found bacterial, while in 22,2% viral pathogens. Ureaplasma parvum and Gardnerella vaginalis were detected in 61,36% and 69,31%, respectively, while Mycoplasma hominis and Ureaplasma urealyticum in equivalent rate 2,27% of the positive for bacterial pathogens samples. HHV7, EBV, HHV6, CMV, HSV2 were detected in 42,5%, 40%, 10%, 7,5%, 2,5% of the positive for viral factors samples. Variable combinations of bacterial and/or viral co-infection were found in 39,9% of all infected patients. Infections with the rest of target pathogens were not detected in the menstrual tissue samples. Conclusions: Our research offers new approach for noninvasive diagnostics of infections in the upper female genital tract by analyzing menstrual tissue as a target biological sample. The detection of asymptomatic bacterial and viral infections or co-infections in female endometrium contributes to the clarification of the infectious etiology of reproductive failure. It is of a great importance for applying of an adequate and individualized therapy.

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Infection and Infertility

Cited by 3 publications

References 82 publications

Prevalence of Various Sexually Transmitted Pathogens in Infertile Couples and Their Effects on In Vitro Fertilization Success

Prevalence of Various Sexually Transmitted Pathogens in Infertile Couples and Their Effects on In Vitro Fertilization Success

A correlative interaction between thyroid dysfunction and semen parameters in male infertility: A prospective case control study

Non-Invasive Diagnostics of Reproductive Failure with Infectious Etiology on Menstrual Tissue

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