Infección por rickettsia en capibaras (Hydrochoerus hydrochaeris) de São Paulo, Brasil: evidencia serológica de infección por Rickettsia bellii y Rickettsia parkeri

Pacheco, Richard C.; Horta, Maurício Cláudio; Moraes‐Filho, Jonas; Ataliba, Alexandre C.; Pintér, Adriano; Labruna, Marcelo Bahia

doi:10.7705/biomedica.v27i3.199

Cited by 74 publications

(45 citation statements)

References 17 publications

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“…It is known that some small animals are highly susceptible to rickettsial infections and could behave as amplifier hosts 3 . In Brazil, capybaras are believed to play an important role in the ecology of BSF 15,24 . Unlike others BSF-endemic areas 12,18,30 , capybaras seem to be absent in Capoeirão Village.…”

Section: Discussionmentioning

confidence: 99%

Rickettsial spotted fever in capoeirão Village, Itabira, Minas Gerais, Brazil

Vianna

Horta

Sangioni

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe present study investigated the infection by spotted fever rickettsia in an endemic area for Brazilian spotted fever (BSF; caused by Rickettsia rickettsii) in Minas Gerais State, Brazil. Human, canine and equine sera samples, and Amblyomma cajennense adult ticks collected in a rural area of Itabira City, Minas Gerais State were tested for rickettsial infection. Through Immunofluorescence Assay (IFA) we demonstrated the presence of antibodies anti-R. rickettsii in 8.2%, 81.3% and 100% of the human, canine and equine sera, respectively. None of the 356 tick specimens analyzed were positive for Rickettsia by the hemolymph test or Polymerase Chain Reaction technique (PCR) for the htrA and the gltA genes. Our serological results on horses and dogs (sentinels for BSF) appoint for the circulation of a SFG Rickettsia in the study area, however in a very low infection rate among the A. cajennense tick population.

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Section: Discussionmentioning

confidence: 99%

Rickettsial spotted fever in capoeirão Village, Itabira, Minas Gerais, Brazil

Vianna

Horta

Sangioni

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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“…Depois de estabelecido os isolados, foi realizado a extração de DNA de uma alíquota de cada inoculo, a qual foi testada por uma bateria de PCR's, objetivando a caracterização molecular dos isolados. Para a realização de cada reação foram utilizados os oligonucleotídeos CS-239 e CS-1069, que amplificam um fragmento de 834pb do gene gltA 11 , oligonucleotídeos 17k-5 e 17k-3, os quais amplificam um fragmento de 549pb do gene htrA (proteína de 17kDa) 11 , oligonucleotídeos 120-M59 e 120-807 para amplificação de uma fragmento de 865pb do gene ompB (proteína de 135kDa) 17 e, por fim uma alíquota dos isolados foi testada pela PCR utilizando os oligonucleotídeos Rr190.70p e Rr190.602n 16 Pacheco e cols 13 , avaliando a infecção por Rickettsia spp pela reação de imunofluorescência indireta (RIFI) em capivaras de seis municípios do Estado de São Paulo, onde nunca houve relatos de FMB em seres humanos, observaram evidências sorológicas de infecção por Rickettsia parkeri em capivaras de apenas um município e, por Rickettsia bellii em outros quatro locais, onde a maior parte das capivaras estavam infestadas por Amblyomma dubitatum. Esses resultados, em conjunto com o presente trabalho, indicam que enquanto a maior parte das populações de Amblyomma dubitatum do Estado de São Paulo encontramse infectada por Rickettsia bellii, a infecção por riquétsias do GFM, como a Rickettsia parkeri, parece ser um achado bem raro nessa espécie de carrapato 11 12 .…”

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Pesquisa de Rickettsia spp em carrapatos Amblyomma cajennense e Amblyomma dubitatum no Estado de São Paulo

Pacheco

Horta

Pintér³

et al. 2009

Rev. Soc. Bras. Med. Trop.

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A febre maculosa brasileira (FMB), doença causada pela bactéria Rickettsia rickettsii, é o principal agravo em conseqüência da infecção por riquétsias do grupo da febre maculosa (GFM) em humanos no Brasil. Casos confirmados de FMB têm sido relatados em determinadas áreas dos Estados da região Sudeste 18 . O carrapato Amblyomma cajennense é incriminado como o principal vetor da doença 5 e, embora não haja comprovação do papel do Amblyomma dubitatum na transmissão da FMB, suspeita-se de sua possível participação na transmissão de riquétsias do GFM para humanos 11 12 . Os eqüinos, capivaras e antas estão entre os principais hospedeiros para todos os estágios parasitários de Amblyomma cajennense 7 , enquanto as capivaras são também hospedeiros primários para o Amblyomma dubitatum 9 . Desta forma, este trabalho buscou avaliar a infecção ABSTRACTThe presence of rickettsial infection was surveyed in 3,545 Amblyomma cajennense ticks and 2,666 Amblyomma dubitatum ticks. Using the hemolymph test, polymerase chain reaction and isolation of Rickettsia in cell cultures, all of the Amblyomma cajennense were negative, whereas 634 (23.8%) of the Amblyomma dubitatum ticks were shown to be infected with Rickettsia bellii.

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“…In the analyzed PSIs, it was possible to observe the prevalence of sites in which both A. cajennense and A. dubitatum could be found; these are the most common ectoparasites found in capybaras (Hydrochoerus hydrochaeris) in the Southeast of Brazil 40 .…”

Section: Discussionmentioning

confidence: 99%

Urbanization of Brazilian spotted fever in a municipality of the southeastern region: epidemiology and spatial distribution

Nasser

Lana²,

Silva³

et al. 2015

Rev. bras. epidemiol.

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Introduction: Brazilian spotted fever is an emerging zoonosis notified mainly in the Southeast of Brazil, especially due to its high level of lethality. Objective: To analyze the epidemiological and spatial pattern of the disease in the municipality of Valinhos (106,793 inhabitants), São Paulo, Southeastern region of Brazil, in the period between 2001 and 2012. Methods: All laboratory-confirmed cases with likely site of infection in the city (n = 49) notified in the Brazilian Case Registry Database were studied. Sites were geocoded using the cartographic base of the city and Google Earth (geographic coordinates) with correction according to the Brazilian Geodetic System. We used the Kernel estimator to analyze the density of the cases on the map. Land cover and distance to basins of all cases were analyzed. Information about tick species and primary hosts were obtained from reports of the Superintendence of Control of Endemic Diseases. Results: Seasonality of the disease was observed with the highest incidence from June to November, and in 2005 and 2011. The most affected groups were men (79.6%) aged 20-49 years old (49%). Lethality was found to be 42.9%. Maps showed the progressive registration of cases in the urban area. Capybaras were reported as the main primary host, and Amblyomma cajennense was identified in probable sites of infection during field investigation. The likely sites of infection were mostly located near basins, dirty pastures, and bordering woods. Conclusions: The transmission pattern of Brazilian spotted fever in Valinhos is similar to that in other cities in the region, where capybara is the main primary host and an amplifier of R. rickettsii. Over the years, a higher occurrence of cases has been identified in the urban area of the city.

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Infección por rickettsia en capibaras (Hydrochoerus hydrochaeris) de São Paulo, Brasil: evidencia serológica de infección por Rickettsia bellii y Rickettsia parkeri

Cited by 74 publications

References 17 publications

Rickettsial spotted fever in capoeirão Village, Itabira, Minas Gerais, Brazil

Rickettsial spotted fever in capoeirão Village, Itabira, Minas Gerais, Brazil

Pesquisa de Rickettsia spp em carrapatos Amblyomma cajennense e Amblyomma dubitatum no Estado de São Paulo

Urbanization of Brazilian spotted fever in a municipality of the southeastern region: epidemiology and spatial distribution

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