Infección por micobacterias no tuberculosas en pacientes con bronquiectasias no causadas por fibrosis quística

Martínez‐Cerón, Elisabet; Prados, C.; Gómez-Carrera, Luis; Cabanillas, J.J.; López–López, Giseth Alexandra; Álvarez-Sala, R.

doi:10.1016/j.rce.2011.08.002

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Our prevalence of 12% of NTM isolation and 8.8% of pNTM disease is in line with a recent meta-analysis reporting a 9.3% overall prevalence of NTM isolation in bronchiectasis patients worldwide and with other data coming from European cohorts and showing NTM isolations in 2%–10% of the subjects [7,11,12,13,14]. Notably, NTM isolation in our cohort was mainly obtained from bronchoscopic specimens.…”

Section: Discussionsupporting

confidence: 90%

Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis

Faverio

Stainer

Bonaiti

et al. 2016

IJMS

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Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients with pulmonary NTM (pNTM) disease. This was a prospective, observational study enrolling 261 adult bronchiectasis patients during the stable state at the San Gerardo Hospital, Monza, Italy, from 2012 to 2015. Three groups were identified: pNTM disease; chronic P. aeruginosa infection; chronic infection due to bacteria other than P. aeruginosa. NTM were isolated in 32 (12%) patients, and among them, a diagnosis of pNTM disease was reached in 23 cases. When compared to chronic P. aeruginosa infection, patients with pNTM were more likely to have cylindrical bronchiectasis and a “tree-in-bud” pattern, a history of weight loss, a lower disease severity and a lower number of pulmonary exacerbations. Among pNTM patients who started treatment, 68% showed a radiological improvement, and 37% achieved culture conversion without recurrence, while 21% showed NTM isolation recurrence. NTM isolation seems to be a frequent event in bronchiectasis patients, and few parameters might help to suspect NTM infection. Treatment indications and monitoring still remain an important area for future research.

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