Nontuberculous mycobacteria in diffuse panbronchiolitis

Tsuji, Takahiro; Tanaka, Eisaku; Yasuda, Ikkoh; Nakatsuka, Yoshinari; Kaji, Yuji; Yasuda, Takehiro; Hashimoto, Seishu; Hwang, Moon Hee; Hajiro, Takashi; Terada, Yoshio

doi:10.1111/resp.12412

Cited by 13 publications

(15 citation statements)

References 32 publications

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“…CT evidence of collapse/consolidation was significantly correlated with isolation of Prevotella species in the bronchoalveolar lavage fluid samples using 16sRNA detecting assay . NTM was also frequently isolated from the sputum of patients with diffuse panbronchiolitis, a disease associated with bronchiectasis . These studies suggest an etiological role of NTM in the pathogenesis of bronchiectasis, which might be exacerbated by co‐infection by anaerobes that cause lung parenchyma changes on CT. Further exploration is required before therapy targeting NTM, and anaerobes can be recommended in clinical practice.…”

Section: Respiratory Infections Tuberculosis and Bronchiectasismentioning

confidence: 79%

Year in review 2015: Lung cancer, pleural diseases, respiratory infections, bronchiectasis and tuberculosis, bronchoscopic intervention and imaging

et al. 2016

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Section: Respiratory Infections Tuberculosis and Bronchiectasismentioning

confidence: 79%

Year in review 2015: Lung cancer, pleural diseases, respiratory infections, bronchiectasis and tuberculosis, bronchoscopic intervention and imaging

et al. 2016

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“…Mycobacterium spp. also easily colonize the respiratory tract of DPB patients because DPB is accompanied mucociliary dysfunction and various bacteria colonize the respiratory epithelium [4]. NTM is a well-recognized pathogen in cystic brosis patients [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Previous retrospective studies have shown that diffuse panbronchiolitis, lung cancer, and rheumatoid arthritis may be associated with NTM disease [4][5][6]. Population-based studies have also identi ed comorbidities such as chronic obstructive pulmonary diseases (COPD), osteoporosis, gastroesophageal re ux (GERD), cystic brosis to be associated with NTM disease [7,8].…”

Section: Introductionmentioning

confidence: 99%

Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: A claims-data analysis

Uno

Aasakura

Morimoto

et al. 2020

Preprint

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Background: Nontuberculous mycobacterial (NTM) lung disease is one of a growing number of chronic health problems that is difficult to cure in aging societies. While it is important to be vigilant about associated comorbidities in order to provide better patient care, data on the prevalence of comorbidities stratified by country or region are scarce. We aimed to elucidate the comorbidities associated with NTM disease based on Japanese health insurance claims data.Methods: Cross-sectional analyses were performed using the claims data for 2014 provided by the Japan Medical Data Center Co., Ltd. Patients aged 20–75 years with ≥3 claims associated with NTM disease were identified and matched to 10 sex-and-age-matched controls that had never made a claim for NTM disease. Thirty-one comorbidities previously suspected to be associated with NTM disease were selected, and the prevalence of these comorbidities compared between cases and controls.Result: Overall, 419 NTM patients (134 males and 285 females) and 4190 non-NTM controls were selected from the JMDC database. Aspergillosis, asthma, bronchiectasis, chronic heart failure, diffuse panbronchiolitis, gastroesophageal reflux, interstitial pneumonia, lung cancer, cancer other than breast, lung, ovary, or prostate cancer, and rheumatic arthritis were associated with NTM disease in both males and females. Chronic obstructive pulmonary disease was associated with NTM in males while chronic kidney disease, osteoporosis, and Sjögren syndrome were associated with NTM in females.Conclusion: NTM disease was associated with multiple comorbidities that should be considered when providing medical care to individuals with NTM disease.

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“…Colonization of the lower respiratory tract by various microorganisms occurs through diverse mechanisms, including impaired immunity in patients with underlying lung disease such as cystic fibrosis bronchiectasis and non-cystic fibrosis bronchiectasis [21,22]. Previous studies also showed that NTM was isolated in a significant proportion of these patients [23][24][25][26]. Therefore, isolation of NTM from bronchial washing or BAL may indicate colonization, especially in patients with underlying lung disease.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis

Sin

Han

Lee

et al. 2020

Preprint

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Background Current microbiologic criteria for nontuberculous pulmonary disease (NTM-PD) require cultures with two separate sputum specimens or one non-sputum specimen. However, data on NTM-PD prognosis following non-sputum culture-based diagnosis are limited. We compared the prognosis of NTM-PD diagnosed using non-sputum and sputum cultures. Methods We analyzed 1020 patients in whom NTM was isolated; they were divided into the sputum NTM isolation (n=170), sputum NTM-PD (n=688), and non-sputum NTM-PD groups (n=162). Initiation of therapy and radiographic aggravation was compared between groups.Results Overall median observation time was 44.3 months (interquartile range, 28.0-70.2). Fewer non-sputum NTM-PD patients initiated treatment than sputum NTM-PD patients (p<0.001). Moreover, fewer non-sputum NTM-PD patients exhibited radiographic aggravation than sputum NTM-PD patients (p=0.001). Both time to radiographic aggravation and initiation of therapy were significantly shorter in the sputum NTM-PD group (log-rank test; p=0.011 and p<0.001, respectively). Sputum NTM-PD patients showed higher initiation of therapy (aHR, 1.38; 95% CI, 1.02-1.87) and risk of radiographic aggravation (aHR, 1.47; 95% CI, 1.02-2.10) than non-sputum NTM-PD patients.Conclusion Prognosis of NTM-PD patients diagnosed with a non-sputum culture was better than that of NTM-PD patients diagnosed with a sputum culture. The disease course may differ depending on the diagnostic method.

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Nontuberculous mycobacteria in diffuse panbronchiolitis

Abstract: Our observations suggest that NTM is found more often in DPB. Defects of mucociliary clearance may predispose individuals to NTM infection.

Cited by 13 publications

References 32 publications

Year in review 2015: Lung cancer, pleural diseases, respiratory infections, bronchiectasis and tuberculosis, bronchoscopic intervention and imaging

Year in review 2015: Lung cancer, pleural diseases, respiratory infections, bronchiectasis and tuberculosis, bronchoscopic intervention and imaging

Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: A claims-data analysis

Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis

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