Infección por el HTLV-I en pacientes con síndromes linfoproliferativos en dos sitios centinela de Cuba

Torres, Héctor Manuel Díaz; Vega, Nereyda Álvarez; Perurena, Jorge E. Muñío; Caballero, Ana Luisa Lubián; Alfonso, Dayamí Martín; Herrera, Dervel Felipe Díaz; Armas, Madelín Blanco de

doi:10.1590/s1020-49892010000100003

Cited by 4 publications

(2 citation statements)

References 19 publications

(22 reference statements)

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“…Reports from non-endemic countries ( n = 17) described HTLV-1-associated diseases in migrants from endemic regions or in specific ethnic groups (Denic et al, 1988, 1990; Ratner and Poiesz, 1988; Mowbray et al, 1989; Dixon et al, 1990; Nightingale and Desselberger, 1990; Nomura et al, 1990; Ratner et al, 1990; Salazar-Grueso et al, 1990; Major et al, 1993; Matutes et al, 1995; Hu et al, 1998; Prates et al, 2000; Biglione et al, 2003; Mahé et al, 2004; Dosik and Wilson, 2009; Díaz Torres et al, 2010). Table 2 summarizes the countries where family aggregation of HTLV-1-associated diseases has been reported.…”

Section: Resultsmentioning

confidence: 99%

Family Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review

Álvarez¹,

Gotuzzo

Vandamme

et al. 2016

Front. Microbiol.

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Human T-lymphotropic virus 1 (HTLV-1) is a retrovirus that produces a persistent infection. Two transmission routes (from mother to child and via sexual intercourse) favor familial clustering of HTLV-1. It is yet unknown why most HTLV-1 carriers remain asymptomatic while about 10% of them develop complications. HTLV-1 associated diseases were originally described as sporadic entities, but familial presentations have been reported. To explore what is known about family aggregation of HTLV-1-associated diseases we undertook a systematic review. We aimed at answering whether, when, and where family aggregation of HTLV-1-associated diseases was reported, which relatives were affected and which hypotheses were proposed to explain aggregation. We searched MEDLINE, abstract books of HTLV conferences and reference lists of selected papers. Search terms used referred to HTLV-1 infection, and HTLV-1-associated diseases, and family studies. HTLV-1-associated diseases considered are adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), HTLV-1-associated uveitis, and infective dermatitis. Seventy-four records reported HTLV-1-associated diseases in more than one member of the same family and were included. Most reports came from HTLV-1-endemic countries, mainly Japan (n = 30) and Brazil (n = 10). These reports described a total of 270 families in which more than one relative had HTLV-1-associated diseases. In most families, different family members suffered from the same disease (n = 223). The diseases most frequently reported were ATLL (115 families) and HAM/TSP (102 families). Most families (n = 144) included two to four affected individuals. The proportion of ATLL patients with family history of ATLL ranged from 2 to 26%. The proportion of HAM/TSP patients with family history of HAM/TSP ranged from 1 to 48%. The predominant cluster types for ATLL were clusters of siblings and parent-child pairs and for HAM/TSP, an affected parent with one or more affected children. The evidence in the literature, although weak, does suggest that HTLV-1-associated diseases sometimes cluster in families. Whether familial transmission of HTLV-1 is the only determining factor, or whether other factors are also involved, needs further research.

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Section: Resultsmentioning

confidence: 99%

Family Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review

Álvarez¹,

Gotuzzo

Vandamme

et al. 2016

Front. Microbiol.

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“…Se transmite por la infusión de sangre, contacto sexual y lactancia materna por tiempo prolongado el cual se considera el factor más importante para desarrollar LLCTA (5,21) .…”

Section: Introductionunclassified

Leucemia Linfoma De Celulas T Del Adulto Y Linfoma Cutaneo Asociados Al HTLV-1

Remón-Torres¹,

Remón-Torres²

2019

RMP

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El virus linfotrópico humano tipo 1 (HTLV-1) se adquiere a través de la lactancia prolongada, contacto sexual e infusión sanguínea, entre el 1-4% de los infectados desarrollan Linfoma Leucemia de Células T del Adulto (LLCTA) con un periodo de latencia entre 30 y 50 años, siendo incurable y mortal a corto plazo, las causas de muerte más frecuentes son infecciones, el linfoma cutáneo de células T es otra manifestación del virus, indicando diseminación. Se presenta el caso de un hombre de 51 años, con hiporexia, odinofagia, lesiones ulceradas necróticas en manos, tórax y cabeza, micosis oral, ingresa por hematemesis, hematoquecia y astenia, presenta, anemia, alteraciones nutricionales y neurológicas. El estudio hematológico diagnosticó LLCTA y la biopsia linfoma cutáneo de células T. El paciente tendría un pronóstico desfavorable.

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Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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Adult T-cell leukemia/lymphoma (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1) which is endemic in countries of Caribbean and Central and South America. We performed a systematic search and review to identify publications on ATL in these countries to verify if this disease was getting recognition in these regions as well as the characteristics of the observed cases. The median age of 49.4 years was lower than that referred to in Japan. According to our findings in most Brazilian states and in some other countries, ATL is not being recognized and should be strongly considered in the differential diagnosis of T-cell leukemias/lymphomas. Failure to identify these cases may be due to the unsystematic realization of serology for HTLV-1 and phenotypic identification of non-Hodgkin lymphomas that may result from lack of resources. Detection of ATL cases has been more feasible with cooperation from foreign research centers. A huge effort should be made to improve the surveillance system for ATL diagnosis in most of the South- and Central-American and Caribbean countries, and this attitude should be embraced by public organs to support health professionals in this important task.

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Infección por el HTLV-I en pacientes con síndromes linfoproliferativos en dos sitios centinela de Cuba

Abstract: The prevalence of HTLV-I in the study group was higher than previously found in Cuba. The value of seroepidemiological surveillance through sentinel sites was confirmed.

Cited by 4 publications

References 19 publications

Family Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review

Family Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review

Leucemia Linfoma De Celulas T Del Adulto Y Linfoma Cutaneo Asociados Al HTLV-1

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

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