Infecção pelo citomegalovírus em pacientes com síndrome da imunodeficiência adquirida (AIDS): relações clínico-virológicas e anatomopatológicas

Turchi, Marília Dalva; Pannuti, Cláudio Sérgio; Sumita, Laura Masami; Boas, Lucy S. Vilas; Weinberg, Adriana; Stávale, João Norberto; Borges, Antonio Fernando Allemand; Collarine, Diva Carvalho; Santos, Honória Virginia Brom dos; Kitadai, Silvia Prado Smit

doi:10.1590/s0036-46651991000400001

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…IgG and IgM antibodies to CMV late antigens were measured using an indirect immunofluorescence assay (IFA) employing antigens prepared in our laboratory, as described previously 23 .…”

Section: Cytomegalovirus Antibody Measurementmentioning

confidence: 99%

Cytomegalovirus infection in children with Down syndrome in a day-care center in Brazil

Canto

Granato

Garcez

et al. 2000

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThis study evaluates the transmission of CMV infection in 120 children aged 1 to 15 years with Down syndrome who attended a day-care center for handicapped children in São Paulo, Brazil. A blood sample was obtained from each children at the beginning of the study for detection of IgG and IgM cytomegalovirus (CMV) antibodies by an immunofluorescence assay. Samples of saliva and urine were obtained every 3 months from the children with CMV antibodies to detect shedding of the virus by culture in human foreskin fibroblasts, by detection of pp65 CMV-antigen and by a nested PCR assay.The prevalence of anti CMV-IgG antibodies was 76.6% (92/120), and IgM anti-CMV antibodies were detected in 13% (12/92) of the seropositive children.During the first viral evaluation, CMV was detected in the urine and/or saliva in 39/90 (43.3%) of the seropositive children. In the second and third evaluations, CMV was detected in 41/89 (46%) and in 35/89 (39.3%) children, respectively. Detection of CMV was shown both in urine and saliva in 28/39 (71.8%), 19/41(46.3%) and 20/35 (57.1%) of the children excreting the virus, respectively. Additionally, in 33/49 (67.4%) of the excreters CMV could be demonstrated in urine or saliva in at least two out of the three virological evaluations carried out sequentially in a six month period.Of the 28 initially seronegative children, 26 were re-examined for anti-CMV IgG antibodies about 18 months after the negative sample; seroconversion was found in 10/26 (38.5%).Taking all 536 samples of urine or saliva examined by virus culture and pp65 antigen detection during the study into account, 159 (29.6%) were positive by virus culture and 59 (11%) gave a positive result with the pp65 assay.These data demonstrate the high prevalence of CMV shedding and the high risk of CMV infection in children with Down syndrome attending a day-care center for mentally handicapped patients. The virus culture was more sensitive than the pp65 CMV antigen assay for CMV detection in both urine and saliva samples.

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“…IgG and IgM antibodies to CMV late antigens were measured using an indirect immunofluorescence assay (IFA) employing antigens prepared in our laboratory, as described previously 23 .…”

Section: Cytomegalovirus Antibody Measurementmentioning

confidence: 99%

Cytomegalovirus infection in children with Down syndrome in a day-care center in Brazil

Canto

Granato

Garcez

et al. 2000

Rev. Inst. Med. trop. S. Paulo

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“…The keywords "AIDS" and "elders" yielded nine articles with no mention of prevalence or LTCFs. Using as keywords "AIDS" and "prevalence," we found a list with 92 citations, some presenting references, at the extremes of age in the sample, to patients aged 60 years or older, 17,18,30,[32][33][34][35][36][37] with no additional information in the text. The prevalence of men with HIV was also observed in these publications, 17,18,[29][30][31][32][33][34][35][36][37] regardless of age range, which is in accordance with the two cases found in our sample.…”

Section: Discussionmentioning

confidence: 99%

Compulsory notification at skilled nursing facilities

Gorzoni¹,

Aguado

Pires

et al. 2017

Rev. Assoc. Med. Bras.

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“…A freqüência é variada nos diversos relatos. Na cidade de São Paulo, por exemplo, a prevalência de CMV em portadores de SIDA foi de 12,5% 30 . Em outro estudo, realizado em hospital público geral, em pacientes imunocompetentes, excluindo-se os portadores de SIDA e neoplasias, detectaram-se 81% de infectados, todos assintomáticos 28 .…”

Section: Considerando-se Os Dois Grupos Definidos Como Controles E Hunclassified

Aspectos da função renal em portadores do vírus da imunodeficiência humana

Mochel

Rosa

Veiga

1998

Rev. Soc. Bras. Med. Trop.

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The occurrence of alterations was verified in some parameters of the asymptomatic individuals' renal function infected by the virus of the human immunodeficiency (HIV). Forty seven individuals were studied, taking place renal functional tests, as: creatinine clearance, clearance of free water, clearance osmolar, reabsorption tubular proximal and distal of sodium and potassium and urinary pH. The results revealed significant differences (p < 0.05) in the urinary pH, larger in the group with HIV (6.36 +/- 0.41), that in the controls (6.02 +/- 0.41); in the clearance of free water, that indicated reabsorption of larger water in the group with HIV (1.00 +/- 0.64 ml/min) and in the clearance osmolar, that was 2.00 +/- 0.83 ml/min in the group with HIV and 1.57 +/- 0.48 ml/min. The remaining of the indicators of renal function was not shown statistically different between an and other group. It was ended that those differences are significant, in spite of the absolute values they be inside of the normality, because could be associated to late evolutionary alterations of the disease, such as the increase of the frequency of infections of the urinary treatment and the dilution hyponatremia. More studies are necessary for if they confirm those hypotheses.

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Infecção pelo citomegalovírus em pacientes com síndrome da imunodeficiência adquirida (AIDS): relações clínico-virológicas e anatomopatológicas

Cited by 4 publications

References 13 publications

Cytomegalovirus infection in children with Down syndrome in a day-care center in Brazil

Cytomegalovirus infection in children with Down syndrome in a day-care center in Brazil

Compulsory notification at skilled nursing facilities

Aspectos da função renal em portadores do vírus da imunodeficiência humana

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