Infecção natural por Trypanosoma evansi em cavalos na região Central do Estado do Rio Grande do Sul

Conrado, Alexandre de Carvalho; Lopes, Sônia Terezinha dos Anjos; Oliveira, Luiz Sergio Segala de; Monteiro, Sílvia González; Vargas, Devaní de Lourdes Batista; Bueno, Alessandra Angélica de Pádua

doi:10.1590/s0103-84782005000400029

Cited by 11 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Trypanosoma evansi é um protozoário flagelado da seção Salivaria, pertencente à classe Mastigophora e família Trypanosomatidae (JOSHI et al, 2005;COLPO et al, 2005;FRANCISCATO et al, 2007;HOSSEININEJAD et al, 2007), sendo o agente causador da doença conhecido como Mal das Cadeiras em equinos (CONRADO et al, 2005;DOYLE et al, 2007;ZANETTE et al, 2008;Da SILVA et al, 2010). De distribuição geográfica mundial, causa doença significativa em animais de áreas de clima tropical, especialmente África e América Latina (CONRADO et al, 2005), tendo sido descrito infectando equinos, cães, gatos, camelos, bovinos, suínos, búfalos, elefantes, antas, veados, capivaras, quatis, pequenos marsupiais, tatus e o homem (JOSHI et al, 2005;DOYLE et al, 2007;ZANETTE et al, 2008;Da SILVA et al, 2010).…”

unclassified

“…De distribuição geográfica mundial, causa doença significativa em animais de áreas de clima tropical, especialmente África e América Latina (CONRADO et al, 2005), tendo sido descrito infectando equinos, cães, gatos, camelos, bovinos, suínos, búfalos, elefantes, antas, veados, capivaras, quatis, pequenos marsupiais, tatus e o homem (JOSHI et al, 2005;DOYLE et al, 2007;ZANETTE et al, 2008;Da SILVA et al, 2010). Dentre as espécies animais que podem atuar como hospedeiro desse agente infeccioso, HOSSEININEJAD et al (2007) descreveram o cão como uma das espécies mais afetadas, sendo a equina, de acordo com ZANETTE et al (2008), a principal espécie afetada em nosso País.…”

unclassified

“…Dentre as espécies animais que podem atuar como hospedeiro desse agente infeccioso, HOSSEININEJAD et al (2007) descreveram o cão como uma das espécies mais afetadas, sendo a equina, de acordo com ZANETTE et al (2008), a principal espécie afetada em nosso País. No Brasil, a doença causada por T. evansi pode se apresentar na forma aguda, rapidamente fatal em equinos, camelos e cães não tratados (ZANETTE et al, 2008); ou crônica, afetando principalmente os animais silvestres (FRANCISCATO et al, 2007 (COLPO et al, 2005;CONRADO et al, 2005;ZANETTE et al, 2008;Da SILVA et al, 2010 (2007), durante a fase aguda da doença, os animais podem apresentar febre intermitente, anemia, edema de membros e partes ventrais do corpo, com emagrecimento progressivo, inapetência, fraqueza e perda de pelos. Acredita-se que ambos os animais do relato apresentavam-se na fase aguda da doença, uma vez que, com exceção do edema em membros e partes ventrais do corpo, todos os demais sinais clínicos de fase aguda foram observados.…”

unclassified

“…A literatura consultada relata que sinais clínicos oculares são observados na fase aguda da tripanossomíase aguda, incluindo conjuntivite, cegueira, lacrimejamento e hifema (CONRADO et al, 2005;HOSSEININEJAD et al, 2007;ZANETTE et al, 2008;Da SILVA et al, 2010), que, embora não sejam citados, são sinais compatíveis com uveíte, corroborando o diagnóstico dessa enfermidade.…”

unclassified

“…Segundo CONRADO et al (2005), uma vez que os sinais clínicos são inespecíficos, o diagnóstico baseia-se nos achados laboratoriais, consistindo principalmente na pesquisa dos protozoários no sangue, líquido cefalorraquidiano e nodos linfáticos, ou na realização de técnicas diagnósticas como testes sorológicos, culturas sanguíneas e inoculação em animais de laboratório.…”

unclassified

See 4 more Smart Citations

Uveíte associada à infecção por Trypanosoma evansi em cães no município de Uruguaiana, RS, Brasil

et al. 2012

View full text Add to dashboard Cite

show abstract

unclassified

See 3 more Smart Citations

Uveíte associada à infecção por Trypanosoma evansi em cães no município de Uruguaiana, RS, Brasil

et al. 2012

View full text Add to dashboard Cite

show abstract

Trypanosoma evansi: Concentration of 3-nitrotyrosine in the brain of infected rats

Paim

Silva

Wolkmer

et al. 2011

Experimental Parasitology

View full text Add to dashboard Cite

Nitric oxide (NO) is involved in many physiological processes, such as blood pressure control, neurotransmission, inhibition of platelet and neutrophil adherence, and the ability to kill tumor cells and parasites. The indirect determination of NO can be made by detection of 3-nitrotyrosine (3-NT) residues. The aim of this study was to measure the concentration of 3-NT in the brain of rats experimentally infected with Trypanosoma evansi. Twenty-four were inoculated intraperitoneally with cryopreserved blood containing 1×10(6) trypomastigotes per animal. Twenty-four animals were used as negative controls and received 0.2 mL of saline by the same route. The experimental groups (group C and T) were established according to the time after infection and the degree of parasitemia as follows: four control subgroups (C3, C5, C10 and C20) with six non-inoculated animals each and four test subgroups (T3, T5, T10 and T20) with six animals infected with T. evansi in each group. The animals were anesthetized with isoflurane and subsequently euthanized at the days 3 (C3, T3), 5 (C5, T5), 10 (C10, T10) and 20 (C20, T20) post-infection (PI). The brain was removed and dissected into cerebellum, cerebral cortex, striatum and hippocampus. Concentration of 3-NT in the brain was determined by Slot blot technique. At the day 3 PI no changes were observed in the concentration of 3-NT among the groups. There was a significant reduction (p<0.05) of 3-NT concentration in the striatum and cerebellum at the days 5 and 10 PI, respectively. At the day 20 PI a significant increase (p<0.05) of 3-NT was observed in the cerebellum, cerebral cortex and hippocampus from the infected animals. Therefore, T. evansi infection caused changes in the concentrations of 3-NT in the central nervous system (CNS), which may be related to clinical signs and infection management.

show abstract

Systematic review and meta-analysis on the global distribution, host range, and prevalence of Trypanosoma evansi

et al. 2019

View full text Add to dashboard Cite

BackgroundSurra is an animal trypanosomosis, caused by infection with Trypanosoma evansi and leading to severe economic loss due to mortality and morbidity. Compared to tsetse-transmitted animal trypanosomoses, little attention is given to the epidemiology and control of surra. Understanding its epidemiology is a first step in local and global efforts to control the disease. We conducted a systematic review and meta-analysis of published studies on distribution, host ranges and prevalence of T. evansi infection.MethodsFour electronic databases were searched for publications on T. evansi that met our inclusion criteria for the systematic review. Subsets of publications were subjected to meta-analysis for the pooled prevalence of T. evansi in various hosts as determined by multiple detection methods.ResultsA total of 272 references published between 1906–2017 were included. Trypanosoma evansi was reported from 48 countries; largely confined to Africa and Asia with publications on natural T. evansi infections from 77% (n = 48) of countries, contrasting with seven countries in South America, and four in Europe where T. evansi is not endemic but was imported with infected animals. Although surra is a notifiable disease, many countries do not report surra cases to OIE. Trypanosoma evansi was mainly reported from dromedary camels in Africa and the Middle East, water buffaloes, cattle, dogs and horses in East and Southeast Asia. In South America, the acute form of the disease was reported in horses and dogs. Surra was also reported in a wide range of wild animals. Some rare human cases occurred in India and Vietnam. Meta-analysis on a subset of 165 publications indicated pooled prevalence of T. evansi in domestic animals ranging from 14–31%, 6–28% and 2–9% using respectively antibody detection, molecular and parasitological tests, with camels as the most affected, followed by buffalo and cattle.ConclusionsThis study illustrates that T. evansi affects a wide range of domestic and wild animals in Africa, Asia and South America with highest prevalence observed in dromedary camels. For successful control of T. evansi, both locally and globally, the role of wild animals in the epidemiology of surra needs further investigation.Electronic supplementary materialThe online version of this article (10.1186/s13071-019-3311-4) contains supplementary material, which is available to authorized users.

show abstract

Infecção natural por Trypanosoma evansi em cavalos na região Central do Estado do Rio Grande do Sul

Abstract: RESUMO

Cited by 11 publications

References 8 publications

Uveíte associada à infecção por Trypanosoma evansi em cães no município de Uruguaiana, RS, Brasil

Uveíte associada à infecção por Trypanosoma evansi em cães no município de Uruguaiana, RS, Brasil

Trypanosoma evansi: Concentration of 3-nitrotyrosine in the brain of infected rats

Systematic review and meta-analysis on the global distribution, host range, and prevalence of Trypanosoma evansi

Contact Info

Product

Resources

About