Infarction of acinic cell carcinoma in a patient infected with HIV: A complication of fine‐needle aspiration cytology obscuring definitive diagnosis

Rau, Aarathi R.; Pai, Radha R.; Nayak, Satheesha B

doi:10.1002/dc.10229

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…7 In analogy to what described in the thyroid, infarction of malignant tumors may impede the histopathological diagnosis. 10 Moreover, infarcted organs may be prone to secondary infection.…”

mentioning

confidence: 99%

Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine‐needle cytology sample

Fulciniti

Losito

Botti

et al. 2009

Diagnostic Cytopathology

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Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine-needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney. In these situations, infarction appears to be directly related to the vascular disturbances caused by needle sampling, though fine this latter might be. One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy. The cytopathologic picture showed a quizzical mixture of necrosis and inflammation coupled to hyperplastic changes of the acinar cells, oncocytic metaplasia, and atypical squamous metaplasia of extreme degree simulating high-grade epidermoid- or mucoepidermoid carcinoma. Due to the cytologically suggestive changes, a nerve-sparing radical parotidectomy was performed. The differential diagnostic problems encountered in this case are discussed together to the possible medical-legal implications originating from such striking atypias as to closely simulate malignancy.

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mentioning

confidence: 99%

Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine‐needle cytology sample

Fulciniti

Losito

Botti

et al. 2009

Diagnostic Cytopathology

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“…Certain tumor types seem to be more prone to infarction, including Warthin tumor, oncocytoma, and acinic cell carcinoma, 2 although this change has also been described in pleomorphic adenoma, canalicular adenoma, mucoepidermoid carcinoma, and myoepithelioma. 13,14,16,25,26 The higher incidence among oncocytic lesions is similar to the experience in the thyroid, where oxyphilic (Hürthle cell) tumors are more prone to infarction than other lesions. 17,20,22,24,27 Some authors theorize that the high cellular oxygen demand of these tumor types, due to an abundance of mitochondria, causes them to be particularly sensitive to changes in perfusion.…”

Section: Discussionmentioning

confidence: 58%

Histologic Effects of Fine-Needle Aspiration Biopsy on Salivary Gland Tumors

Kardon¹,

Torske²

2004

Pathology Case Reviews

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Fine-needle aspiration (FNA) is a safe, tolerable, and accurate method of diagnosis for lesions of the head and neck. The major salivary glands are generally easily accessible and therefore are good candidates for cytologic sampling. Given the anatomic and cosmetic concerns inherent to surgery in this region, FNA is a simple diagnostic procedure for planning a definitive treatment course with negligible risk of morbidity. However, significant controversy concerning its utility in the evaluation of salivary lesions still exists. Both pathologists and clinicians who feel that FNA may be detrimental to patient outcome have voiced concerns that include "seeding" of the needle tract and introducing histopathologic artifacts that may preclude accurate diagnosis. The following 2 cases illustrate many of the defined histologic changes associated with aspiration biopsy, and the discussion examines the incidence and significance of FNA effects on salivary gland pathology as reported in the medical literature.

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“…[6,7] Another issue encountered is inadequate aspiration and poor cellularity. [8] Ultrasound guided aspiration may be helpful in obtaining better aspirate and decrease the number of unsatisfactory smears.…”

Section: Discussionmentioning

confidence: 99%

Cytological and Histomorphological Correlation of Salivary Gland Lesions- An Experience at Rural Tertiary Healthcare Hospital

Thangam

Kotasthane

et al. 2017

APALM

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Background: Salivary gland tumours account for 3-10% of all the head and neck neoplasm. FNAC is being increasingly used in the diagnosis of salivary gland tumours. The objective of this study was to evaluate the age, sex and site distribution and to evaluate the diagnostic accuracy of fine needle aspiration cytology (FNAC) in various salivary gland lesions in correlation with their histopathology, which helps in appropriate management of the patient. Methods:The present study was done at the pathology department, Mahatma Gandhi Medical College and Research Institute, Pondicherry. FNAC was done using 22 gauge needle and 10 ml syringe and smears were stained with H&E and Giemsa stains. Histopathology was assessed on routine H&E stained paraffin sections .Cyto-histo correlation was done and overall diagnostic accuracy, sensitivity and specificity were calculated. Results:The study was conducted on 122 patients having salivary gland lesions .The age ranged from 24-80 years. Benign tumours were common in 3rd decade, whereas malignant tumours in 6th decade of life. There was female preponderance with male to female ratio of 1:1.03.Parotid glands were commonly involved in 74(78.72%).Out of 94 neoplastic cases,78(82.97%)were benign and 14(14.89%) were malignant. Pleomorphic adenoma was the commonest lesion observed accounted for 68.08%. Conclusion:The Overall sensitivity, specificity and diagnostic accuracy were 80%, 94.74% and 91.66% respectively. FNAC of the salivary gland is safe, rapid ,accurate and reliable technique in the primary diagnosis of salivary gland lesions and useful in avoiding surgery (in inflammatory lesions) or limiting surgical procedures(in benign tumours).

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Infarction of acinic cell carcinoma in a patient infected with HIV: A complication of fine‐needle aspiration cytology obscuring definitive diagnosis

Cited by 6 publications

References 6 publications

Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine‐needle cytology sample

Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine‐needle cytology sample

Histologic Effects of Fine-Needle Aspiration Biopsy on Salivary Gland Tumors

Cytological and Histomorphological Correlation of Salivary Gland Lesions- An Experience at Rural Tertiary Healthcare Hospital

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