Infants born preterm, stress, and neurodevelopment in the neonatal intensive care unit: might music have an impact?

Anderson, Dane E; Patel, Aniruddh D.

doi:10.1111/dmcn.13663

Cited by 119 publications

(117 citation statements)

References 69 publications

(135 reference statements)

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“…Therefore, there has been an increased interest in introducing music interventions in neonatal intensive care units (NICU). A number of authors have considered the effects of music listening in preterm infants and many have shown stabilizing effects on heart and respiratory rates, reduction of apnea or bradycardia, improved resting energy expenditure, improved feeding, better weight gain and more mature sleep patterns; and most of them report a beneficial effect on at least one of these outcomes (Haslbeck, 2012;Filippa et al, 2017;Pineda et al, 2016;Anderson and Patel, 2018). Nevertheless, these music interventions have been proposed for enhancing neonatal intensive care environments without knowing the preterm brains ability to process music.…”

Section: Introductionmentioning

confidence: 99%

Music processing in preterm and full-term newborns: A psychophysiological interaction (PPI) approach in neonatal fMRI

et al. 2019

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A B S T R A C TNeonatal Intensive Care Units (NICU) provide special equipment designed to give life support for the increasing number of prematurely born infants and assure their survival. More recently NICU's strive to include developmentally oriented care and modulate sensory input for preterm infants. Music, among other sensory stimuli, has been introduced into NICUs, but without knowledge on the basic music processing in the brain of preterm infants. In this study, we explored the cortico-subcortical music processing of different types of conditions (Original music, Tempo modification, Key transposition) in newborns shortly after birth to assess the effective connectivity of the primary auditory cortex with the entire newborn brain. Additionally, we investigated if early exposure during NICU stay modulates brain processing of music in preterm infants at term equivalent age. We approached these two questions using Psychophysiological Interaction (PPI) analyses. A group of preterm infants listened to music (Original music) starting from 33 weeks postconceptional age until term equivalent age and were compared to two additional groups without music intervention; preterm infants and full-term newborns. Auditory cortex functional connectivity with cerebral regions known to be implicated in tempo and familiarity processing were identified only for preterm infants with music training in the NICU. Increased connectivity between auditory cortices and thalamus and dorsal striatum may not only reflect their sensitivity to the known music and the processing of its tempo as familiar, but these results are also compatible with the hypothesis that the previously listened music induces a more arousing and pleasant state. Our results suggest that music exposure in NICU's environment can induce brain functional connectivity changes that are associated with music processing.

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Section: Introductionmentioning

confidence: 99%

Music processing in preterm and full-term newborns: A psychophysiological interaction (PPI) approach in neonatal fMRI

et al. 2019

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“…This burden has been associated with increased oxygen demand and cerebral oxygenation disturbances . Such exposure has been associated with neurodevelopmental morbidity later in life . It has also reported that neonates can experience prolonged negative effects from pain, with permanent changes in endocrine, immune and behavioural reactivity to stressful events in childhood and continuing through adult life …”

Section: Introductionmentioning

confidence: 99%

“…A systematic review concluded that there is evidence for some therapeutic effects of music intervention on physiological and behavioural parameters, but cautioned that the methodological quality of the studies included was generally poor . A further review detailed how repeated stress may be associated with negative neurodevelopmental outcomes in preterm infants and stated that while studies including music intervention reviewed have a positive measurable physiological or behavioural impact, the relative effect size remains unclear …”

Section: Introductionmentioning

confidence: 99%

No effect of a musical intervention on stress response to venepuncture in a neonatal population

et al. 2019

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Aim To investigate the effect of a musical intervention on neonatal stress response to venepuncture as measured by salivary cortisol levels and pain profile scores. Methods In a randomised control crossover trial, participants were randomised to both a control arm (sucrose) and intervention arm (sucrose and music) for routine venepuncture procedures. Salivary swabs were collected at baseline, 20 minutes post‐venepuncture and 4 hours post‐venepuncture. Pain levels were assessed using the Premature Infant Pain Profile (PIPP). A total of 16 preterm neonates participated in both arms to complete the study. Results Cortisol values were elevated at all timepoints in the intervention arm (baseline, 20 minutes, and 4 hours post‐procedure) but not significantly so (P = .056, P = .3, and P = .575, respectively). Median change in cortisol values from baseline was +128.48 pg/mL (−47.66 to 517.02) at 20 minutes and +393.52 pg/mL (47.88‐1221.34) at 4 hours post‐procedure in the control arm compared to −69.564 pg/mL (−860.96 to 397.289) and +100.48 pg/mL (−560.46 to 842.99) at 20 minutes and 4 hours post‐procedure in the intervention arm. There was no statistically significant difference observed between groups (P = .311 at 20 minutes, and P = .203 at 4 hours post‐procedure). PIPP scores were not significantly different between study arms. Conclusion Our findings did not support the additional benefit of music intervention on neonatal stress response to venepuncture in preterm infants.

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“…Infants born preterm are particularly vulnerable to brain structure abnormalities that persist into later life. Non‐invasive music (therapy) interventions – as exemplified by the case vignette above, and as argued by Anderson and Patel – are one of the growing areas of interdisciplinary interest for attenuating the stress response in infants born preterm.…”

mentioning

confidence: 99%

“…Anderson and Patel state that music may function as a surrogate supportive social signal in infants born preterm, especially when frequent physical contact may be difficult. Additionally, Arnon et al .…”

mentioning

confidence: 99%

The effect of music therapy on infants born preterm

Haslbeck

Stegemann

2018

Develop Med Child Neuro

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Infants born preterm, stress, and neurodevelopment in the neonatal intensive care unit: might music have an impact?

Cited by 119 publications

References 69 publications

Music processing in preterm and full-term newborns: A psychophysiological interaction (PPI) approach in neonatal fMRI

Music processing in preterm and full-term newborns: A psychophysiological interaction (PPI) approach in neonatal fMRI

No effect of a musical intervention on stress response to venepuncture in a neonatal population

The effect of music therapy on infants born preterm

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